Anisakis simplex allergy and nephrotic syndrome

Meseguer, Juan; Navarro, Victor J.; Sánchez-Guerrero, I.; Bartolomé, B; Álvarez, José María

doi:10.1157/13110318

Cited by 9 publications

(5 citation statements)

References 16 publications

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“…Non-occupational airborne-induced anaphylaxis after exposure to Anisakis allergens has been also reported [31]. The allergic response caused by Anisakis could also be associated with nephrotic syndrome and rheumatic manifestations [32,33].…”

Section: Introductionmentioning

confidence: 99%

Proteomic and Bioinformatic Investigations of Heat-Treated Anisakis simplex Third-Stage Larvae

et al. 2020

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Anisakis simplex third-stage larvae are the main source of hidden allergens in marine fish products. Some Anisakis allergens are thermostable and, even highly processed, could cause hypersensitivity reactions. However, Anisakis proteome has not been studied under autoclaving conditions of 121 °C for 60 min, which is an important process in the food industry. The aim of the study was the identification and characterization of allergens, potential allergens, and other proteins of heat-treated A. simplex larvae. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to identify 470 proteins, including allergens—Ani s 1, Ani s 2, Ani s 3, Ani s 4, Ani s 5—and 13 potential allergens that were mainly homologs of Anisakis spp., Ascaris spp., and Acari allergens. Ani s 2, Ani s 3, Ani s 5, and three possible allergens were found among the top 25 most abundant proteins. The computational analysis allowed us to detect allergen epitopes, assign protein families, and domains as well as to annotate the localization of proteins. The predicted 3D models of proteins revealed similarities between potential allergens and homologous allergens. Despite the partial degradation of heated A. simplex antigens, their immunoreactivity with anti-A. simplex IgG antibodies was confirmed using a Western blot. In conclusion, identified epitopes of allergenic peptides highlighted that the occurrence of Anisakis proteins in thermally processed fish products could be a potential allergic hazard. Further studies are necessary to confirm the IgE immunoreactivity and thermostability of identified proteins.

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Section: Introductionmentioning

confidence: 99%

Proteomic and Bioinformatic Investigations of Heat-Treated Anisakis simplex Third-Stage Larvae

et al. 2020

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“…Nos encontramos ante un caso de nefritis tubulointersticial aguda asociada a hipersensibilidad a Es cierto que, para ser un caso típico, carece de eosinofilia en plasma y eosinofiluria. Por otro lado, aunque el hecho de no haber encontrado en la bibliografía más casos sobre patología renal asociada a Anisakis, excepto un único caso de síndrome nefrótico asociado a alergia a este nematodo 4 , dificulta el diagnóstico, se ha descrito que las nefritis intersticiales agudas pueden poseer componente alérgico o de hipersensibilidad, especialmente las asociadas a fármacos 5,6 e infecciones, que provocarían una reacción inmunitaria tras el depósito intersticial de «antígenos plantados» 6 . Además, en cuanto al Anisakis, es bien conocido su potencial alergénico, y se sabe que las larvas pueden llegar hasta el intestino delgado, atravesar la mucosa y provocar granulomas eosinófilos, y los síntomas aparecen entre 1 y 2 semanas tras la exposición, y con clínica de dolor abdominal intermitente, clínica digestiva y fiebre 1 , similar a la que presentó nuestra paciente.…”

Section: Discussionunclassified

Nefritis tubulointersticial aguda asociada a consumo de Anisakis en paciente alérgica

Tomás-Latorre¹,

Peña-Porta²,

Moros-García³

et al. 2020

NEFRO

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Presentamos el caso de una paciente de 70 años, con el único antecedente médico de interés de anafilaxia por Anisakis, que presenta un fracaso renal agudo con biopsia compatible con nefritis tubulointersticial de etiología alérgica tras la ingesta de pescado. A pesar de que no se ha publicado ningún caso previo de nefritis por hipersensibilidad a Anisakis, la clínica, evolución y biopsia fueron compatibles con esta sospecha, sin poderse encontrar otra posible etiología del fracaso renal agudo.

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“…Anisakis simplex has also been identified as an allergen which elicits allergic inflammation in experimental and clinical patients (5,6). Humans become infected with A. simplex (anisakidosis) via the consumption of marine fish or cephalodods contaminated by third stage larvae.…”

Section: Introductionmentioning

confidence: 99%

Parasite excretory-secretory proteins elicit TRIF dependent CXCL1 and IL-6 mediated allergic inflammation

Kim

et al. 2010

Parasite Immunology

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Currently, little information is available regarding innate immunity to helminthic parasite infection. In this study, we isolated the excretory-secretory (ES) proteins from Anisakis simplex (sea mammal intestinal parasite) third stage larva. We determined that the levels of IL-17 in the lung and lung draining lymph node of mice were increased sixfold as a result of intranasal treatment with ES proteins. The ES protein treatment elicited pro-inflammatory cytokine and chemokine secretion (especially IL-6 and CXCL1) from mouse lung epithelial cell line and primary lung epithelial cells. In addition, the expression of IL-6 and CXCL1 in mouse embryonic fibroblast (MEF) cells was significantly increased by the ES protein treatment, but we did not detect these effects in the TRIF(-/-) MEF cells. These elevations of IL-6 and CXCL1 expression were also not diminished by RNase treatment. In conclusion, the ES proteins of helminthic parasite larva may elicit TRIF dependent pro-inflammatory cytokines, and this is not double-stranded RNA.

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Anisakis simplex allergy and nephrotic syndrome

Abstract: These data suggest, for the first time, the association between allergy to A. simplex and nephrotic syndrome.

Cited by 9 publications

References 16 publications

Proteomic and Bioinformatic Investigations of Heat-Treated Anisakis simplex Third-Stage Larvae

Proteomic and Bioinformatic Investigations of Heat-Treated Anisakis simplex Third-Stage Larvae

Nefritis tubulointersticial aguda asociada a consumo de Anisakis en paciente alérgica

Parasite excretory-secretory proteins elicit TRIF dependent CXCL1 and IL-6 mediated allergic inflammation

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