Anisocoria in the dog provoked by a toxic contact with an ornamental plant: <i>Datura stramonium</i>

Hansen, P. V.; Clerc, Bernard

doi:10.1046/j.1463-5224.2002.00224.x

Cited by 20 publications

(12 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pathological changes were considered to suggest an evolution towards hypotension, heart failure, disseminated intravascular coagulation and multiple organ failure 74 . A case of repeated anisocoria in a dog that was caused by contact with damaged plant material has been described 25 .…”

Section: Solanaceaementioning

confidence: 99%

Potential plant poisonings in dogs and cats in southern Africa : review article

Botha¹,

Penrith²

2009

J. S. Afr. Vet. Assoc.

View full text Add to dashboard Cite

Plant poisoning occurs less commonly in dogs and cats than in herbivorous livestock, but numerous cases have been documented worldwide, most of them caused by common and internationally widely cultivated ornamental garden and house plants. Few cases of poisoning of cats and dogs have been reported in southern Africa, but many of the plants that have caused poisoning in these species elsewhere are widely available in the subregion and are briefly reviewed in terms of toxic principles, toxicity, species affected, clinical signs, and prognosis. The list includes Melia azedarach (syringa), Brunfelsia spp. (yesterday, today and tomorrow), Datura stramonium (jimsonweed, stinkblaar), a wide variety of lilies and lily-like plants, cycads, plants that contain soluble oxalates, plants containing cardiac glycosides and other cardiotoxins and euphorbias (Euphorbia pulcherrima, E. tirucalli). Poisoning by plant products such as macadamia nuts, onions and garlic, grapes and raisins, cannabis (marijuana, dagga) or hashish and castor oil seed or seedcake is also discussed. Many of the poisonings are not usually fatal, but others frequently result in death unless rapid action is taken by the owner and the veterinarian, underlining the importance of awareness of the poisonous potential of a number of familiar plants.

show abstract

Section: Solanaceaementioning

confidence: 99%

Potential plant poisonings in dogs and cats in southern Africa : review article

Botha¹,

Penrith²

2009

J. S. Afr. Vet. Assoc.

View full text Add to dashboard Cite

show abstract

“…In addition, the history of exposure to alkaloid agents clarifies the pathogenic mechanism of the clinical findings. In fact, accidental mydriasis from exposure to plant components has been previously reported in humans and animals, but to the best of our knowledge, this is the first report of an acute glaucoma attack following accidental contact with Datura in a patient with NF1 [9, 10, 13]. …”

Section: Discussionmentioning

confidence: 99%

Unusual Case of Angle Closure Glaucoma in a Patient with Neurofibromatosis Type 1

Mantelli

Abdolrahimzadeh

Mannino

et al. 2014

Case Rep Ophthalmol

View full text Add to dashboard Cite

We report the case of a 29-year-old female patient who presented with an acute onset of anisocoria, blurred vision, nausea and severe left-sided headache. There was no history of trauma, drug abuse, or instillation of topical mydriatic compounds. The ocular history was negative for similar events. On presentation, her visual acuity was 0.2 in the left and 1.0 in the right eye with a +2.5 dpt sph. correction. Slit-lamp examination demonstrated a shallow anterior chamber as well as the presence of iris nodules in both eyes. These nodules were identified as Lisch nodules as the patient referred to the previous diagnosis as being neurofibromatosis type 1. A third nerve palsy was considered, but a brain MRI showed normal results. Her ocular motility was normal, but the left pupil was mydriatic and poorly reacting to light, with an associated raised intraocular pressure (IOP) of 38 mm Hg. An examination of the fellow eye was normal, with the IOP measuring 18 mm Hg. Gonioscopy of the right eye showed a narrow angle. On further anamnestic investigation, the patient revealed that the pain and the blurred vision begun in the morning while she was helping her mother in the garden. Finally, after showing the patient a picture of Datura flowers, which she recognized immediately, we made the unusual diagnosis of angle closure glaucoma by Datura, a well-known toxic plant with mydriatic properties. The patient was successfully treated with systemic acetazolamide and topical pilocarpine.

show abstract

“…In the other case mydriasis of one of the eyes was reported in a five year-old Griffon dog (Hansen and Clerc, 2002). The authors performed experimental studies on dogs, which showed that contact with any part of D. stramonium could induce this condition.…”

Section: Dogsmentioning

confidence: 98%

Tropane alkaloids (from Datura sp.) as undesirable substances in animal feed - Scientific Opinion of the Panel on Contaminants in the Food Chain

2008

EFSA Journal

View full text Add to dashboard Cite

SUMMARYThe term tropane alkaloids refers to a group of more than 200 compounds best known for their occurrence in the family Solanaceae comprising over 100 genera and 3000 plant species. They have in common a two-ringed structure characterized by a pyrrolidine and a piperidine ring sharing a single nitrogen atom and two carbons atoms. The nitrogen atom at the end of the molecule, which characterizes the compounds as alkaloids, is in this group characteristically methylated. The most important natural tropane alkaloids are (-)-hyoscyamine and (-)-scopolamine (also known as hyoscine). High concentrations of these alkaloids have been found particularly in Datura stramonium and Datura ferox, as well as in Datura innoxia. The pattern of tropane alkaloids differs significantly and in Datura stramonium (also known as thorn apple or Jimson weed) hyoscyamine prevails in most parts of the plant, whereas in Datura ferox scopolamine is the major alkaloid Tropane alkaloids as undesirable substances in animal feedThe EFSA Journal (2008) 691, 2-55 produced. Datura plants are toxic for animals if ingested in larger amounts. Their seeds, which contain significant amounts of hyoscyamine and scopolamine, can be found as botanical impurities in feed materials, particularly in soybean and linseed products.Very little information on the actual contamination of feed materials is available, and previous reports on adverse health effects in animals refer in most cases to accidental intoxications following the consumption of Datura plants rather than to the contamination of linseed and sobean contaning feed materials. Hence no conclusive exposure assessment could be presented for farm animals.Overall, pigs have been shown to be among the most sensitive species to Datura poisoning. A worst case exposure estimate indicated that adverse pharmacological effects in pigs following exposure to Datura ferox seeds, mainly containing scopolamine, can not be entirely excluded at the current statutory limits of 3000 mg/kg feed. However, the limited data also suggested that it is not likely that the presence of Datura stramonium impurities in animals feed up to the current statutory level of 1000 mg/kg would present a risk to animal health.The mechanism of action of tropane alkaloids relates to their competitive antagonism at muscarinic acetylcholine receptors, preventing the binding of acetylcholine. According to the specificity and selectivity of muscarinergic acetylcholine receptors in different organs, the functions of smooth muscles and exocrine gland cells, as well as the heart rate, respiration and functions in the central nervous system are modulated. Certain tropanes such as atropine (the racemic mixture of (-)-and (+)hyoscyamine) as well as scopolamine (mainly as butylscopolamine bromide) are used in human and veterinary therapy for a variety of related indications. Reports of poisoning of livestock and experimental feeding studies describe as most common symptoms associated with tropane alkaloids exposure dryness of the mucosa in the uppe...

show abstract

Anisocoria in the dog provoked by a toxic contact with an ornamental plant: Datura stramonium

Cited by 20 publications

References 7 publications

Potential plant poisonings in dogs and cats in southern Africa : review article

Potential plant poisonings in dogs and cats in southern Africa : review article

Unusual Case of Angle Closure Glaucoma in a Patient with Neurofibromatosis Type 1

Tropane alkaloids (from Datura sp.) as undesirable substances in animal feed - Scientific Opinion of the Panel on Contaminants in the Food Chain

Contact Info

Product

Resources

About