Anisotropic Fiber-Reinforced Glycosaminoglycan Hydrogels for Heart Valve Tissue Engineering

Ravishankar, Prashanth; Ozkızılcık, Asya; Husain, Anushae; Balachandran, Kartik

doi:10.1089/ten.tea.2020.0118

Cited by 29 publications

(28 citation statements)

References 76 publications

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“…Centrifugal spinning has also benefitted vascular regeneration, more specifically heart valve tissue engineering. Blending PCL and gelatin yielded centrifugally spun aligned fibers which were then embedded in methacrylated hydrogels to produce fiber enforced hydrogels [449]. The authors found that combining fibers with hydrogels yielded constructs capable of mimicking the mechanical stresses of heart values whilst promoting cell attachment and proliferation.…”

Section: Centrifugal Spinningmentioning

confidence: 99%

“…SEM images of Chitosan based composite centrifugally spun fibers loaded with cinnamaldehyde and c) 7% chitosan and d) 9% chitosan for potential wound dressings: reproduced from [428]. PCL-gelatin fibers utilised for heart valve tissue engineering e) SEM image showing fiber surface morphology and f) Digital image of PCL-gelatin fibers collected on the reservoir surface: reproduced from [449]. Fluorescence imaging of g) highly aligned multi-fiber integration using electrospun PVP and polystyrene: reproduced from [29].…”

Section: List Of Tables and Figuresmentioning

confidence: 99%

“…PCL-gelatin fibers utilised for heart valve tissue engineering e) SEM image showing fiber surface morphology and f) Digital image of the PCL-gelatin fibers collected on the reservoir surface. Reproduced from [449]. Fluorescence imaging of g) highly aligned multi-fiber integration using electrospun PVP and polystyrene.…”

Section: List Of Tables and Figuresmentioning

confidence: 99%

See 2 more Smart Citations

Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics

Mehta

Rasekh

Patel

et al. 2021

Advanced Drug Delivery Reviews

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Section: Centrifugal Spinningmentioning

confidence: 99%

Section: List Of Tables and Figuresmentioning

confidence: 99%

See 1 more Smart Citation

Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics

Mehta

Rasekh

Patel

et al. 2021

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

“…Hydrogel/spun fiber scaffolds have attracted a myriad of research interests in the complex arrangement of ECM in various tissues. [ 199–201 ] A spinning fiber composite hydrogel with conductive property is studied. The spinning is put into the hydrogel, and the 3D structure is formed by ultrasonic stimulation.…”

Section: Multi‐d Composite Materialsmentioning

confidence: 99%

“…Hydrogel/spun fiber scaffolds have attracted a myriad of research interests in the complex arrangement of ECM in various tissues. [199][200][201] A spinning fiber [194] Copyright 2018, American Chemical Society. B) A schematic diagram of the shape memory cycle of a lightly cross-linked telechelic biopolymers, with a random coil-like middle block and collagen-like end blocks.…”

Section: Physical Stimuli-responsive Hydrogelsmentioning

confidence: 99%

Hydrogel Composites with Different Dimensional Nanoparticles for Bone Regeneration

Yang

Fang

et al. 2021

Macromol. Rapid Commun.

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The treatment of large segmental bone defects and complex types of fractures caused by trauma, inflammation, or tumor resection is still a challenge in the field of orthopedics. Various natural or synthetic biological materials used in clinical applications cannot fully replicate the structure and performance of raw bone. This highlights how to endow materials with multiple functions and biological properties, which is a problem that needs to be solved in practical applications. Hydrogels with outstanding biocompatibility, for their casting into any shape, size, or form, are suitable for different forms of bone defects. Therefore, they have been used in regenerative medicine more widely. In this review, versatile hydrogels are compounded with nanoparticles of different dimensions, and many desirable features of these materials in bone regeneration are introduced, including drug delivery, cell factor vehicle, cell scaffolds, which have potential in bone regeneration applications. The combination of hydrogels and nanoparticles of different dimensions encourages better filling of bone defect areas and has higher adaptability. This is due to the minimally invasive properties of the material and ability to match irregular defects. These biological characteristics make composite hydrogels with different dimensional nanoparticles become one of the most attractive options for bone regeneration materials.

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A Biomimetic Leaflet Scaffold for Aortic Valve Remodeling

De Jesus Morales,

Santosa,

Brazhkina

et al. 2024

Adv Healthcare Materials

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Heart valve disease poses a significant clinical challenge, especially in pediatric populations, due to the inability of existing valve replacements to grow or respond biologically to their microenvironment. Tissue‐engineered heart valves (TEHVs) provide a solution by facilitating patient‐specific models for self‐repair and remodeling. In this study, a 3D bioprinted TEHV is designed to emulate the tri‐layer leaflet structure of an aortic valve. A cell‐laden hydrogel scaffold made from gelatin‐methacrylate and polyethylene glycol diacrylate (GelMA/PEGDA) incorporates valvular interstitial‐like (VIC‐like) cells, being reinforced with a layer of polycaprolactone (PCL). The composition of the hydrogel scaffold remains stable over 7 days, having increased mechanical strength compared to pure GelMA. The scaffold maintains VIC‐like cell function and promotes extracellular matrix (ECM) protein expression up to 14 days under two dynamic culture conditions: shear stress and stretching; replicating heart valve behavior within a more physiological‐like setting and suggesting remodeling potential via ECM synthesis. This TEHV offers a promising avenue for valve replacements, closely replicating the structural and functional attributes of a native aortic valve, leading to mechanical and biological integration through biomaterial‐cellular interactions.This article is protected by copyright. All rights reserved

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Anisotropic Fiber-Reinforced Glycosaminoglycan Hydrogels for Heart Valve Tissue Engineering

Cited by 29 publications

References 76 publications

Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics

Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics

Hydrogel Composites with Different Dimensional Nanoparticles for Bone Regeneration

A Biomimetic Leaflet Scaffold for Aortic Valve Remodeling

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