Anisotropic Microparticles from Microfluidics

Cai, Lijun; Bian, Feika; Chen, Hanxu; Guo, Jiahui; Wang, Yongan; Zhao, Yuanjin

doi:10.1016/j.chempr.2020.09.023

Cited by 70 publications

(53 citation statements)

References 179 publications

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“…Accordingly, droplet templates from the microfluidics system are obtained due to the dragging force which has an intensity that is higher than that of the viscosity force. [ 44 ] The droplet formation modes can be applied to various channel geometries including cross‐flow, coflow, and flow‐focusing. [ 45 ] Particularly, microparticles with greater structural complexity (multicore, higher‐order) can be achieved by incorporating additional compartments in the microfluidic chip.…”

Section: Methods For Multilayer Microencapsulation: Operating Paramet...mentioning

confidence: 99%

Biopolymer‐Based Multilayer Microparticles for Probiotic Delivery to Colon

Talebian

Schofield

Valtchev

et al. 2022

Adv Healthcare Materials

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The potential health benefits of probiotics may not be realized because of the substantial reduction in their viability during food storage and gastrointestinal transit. Microencapsulation has been successfully utilized to improve the resistance of probiotics to critical conditions. Owing to the unique properties of biopolymers, they have been prevalently used for microencapsulation of probiotics. However, majority of microencapsulated products only contain a single layer of protection around probiotics, which is likely to be inferior to more sophisticated approaches. This review discusses emerging methods for the multilayer encapsulation of probiotic using biopolymers. Correlations are drawn between fabrication techniques and the resultant microparticle properties. Subsequently, multilayer microparticles are categorized based on their layer designs. Recent reports of specific biopolymeric formulations are examined regarding their physical and biological properties. In particular, animal models of gastrointestinal transit and disease are highlighted, with respect to trials of multilayer microencapsulated probiotics. To conclude, novel materials and approaches for fabrication of multilayer structures are highlighted.

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Section: Methods For Multilayer Microencapsulation: Operating Paramet...mentioning

confidence: 99%

Biopolymer‐Based Multilayer Microparticles for Probiotic Delivery to Colon

Talebian

Schofield

Valtchev

et al. 2022

Adv Healthcare Materials

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show abstract

“…Moreover, sealed microfluidic channels isolate fluids from bacteria and small molecules in the atmosphere, allowing simultaneous encapsulation of cells while manipulating microfluids. Beyond the production of isotropic biomaterials, biocarriers with various morphologies and complex structures such as multicompartment and core/shell can also be manufactured via the flexible design and modification of microfluidic devices [9].…”

Section: Future Perspectivesmentioning

confidence: 99%

Biomaterials for microfluidic technology

Chen

Zhang

et al. 2022

Mater. Futures

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Micro/nanomaterial-based drug and cell delivery systems play an important role in biomedical fields for their injectability and targeting. Microfluidics is a rapidly developing technology and has become a robust tool for preparing biomaterial micro/nanocarriers with precise structural control and high reproducibility. By flexibly designing microfluidic channels and manipulating fluid behavior, various forms of biomaterial carriers can be fabricated using microfluidics, including microspheres, nanoparticles and microfibers. In this review, recent advances in biomaterials for designing functional microfluidic vehicles are summarized. We introduce the application of natural materials such as polysaccharides and proteins as well as synthetic polymers in the production of microfluidic carriers. How the material properties determine the manufacture of carriers and the type of cargoes to be encapsulated is highlighted. Furthermore, the current limitations of microfluidic biomaterial carriers and perspectives on its future developments is presented.

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“…[1][2][3] Researchers have been able to flexibly design and prepare different MPRs with the required structures and interface characteristics as expected, such as particles, colloidosomes, vesicles, gel-microspheres, and multiple polymersomes. [4,5] The remarkable interface characteristics, endowing the mentioned MPRs…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the types, preparation methods, and biomedical applications of MPRs have been systematically presented in several excellent reviews. [3][4][5][8][9][10][17][18][19][20] The thermodynamic properties of liquid-liquid droplet reactors have been analyzed more specifically in some reviews. [7,17] However, the origin of interface characteristics of MPRs, as well as the function and cuttingedge cell-and drug-related biomedical applications determined by the interface characteristics, are deficient in a systematic summary.…”

mentioning

confidence: 99%

Microfluidic Particle Reactors: From Interface Characteristics to Cells and Drugs Related Biomedical Applications

Xin

et al. 2022

Adv Materials Inter

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with advanced functions, [6] can be attributed to two aspects. 1) The exquisite control and manipulation abilities of fluids at a microscale have reached a new height as droplet microfluidic technology is leaping forward. The precisely tunable interface characteristics of emulsion templates, determined by the optimization of fluids composition and interfacial complexity, contribute to the inherent interface properties of MPRs. [7][8][9][10] 2) The introduction of advanced materials expands the interface characteristics of the MPRs. Considerable natural polymers, synthetic polymers, and stimuli-responsive biomaterials have been employed continuously with the development of materials science. As a result, a series of performances possessed by the materials can significantly improve the inherent interface characteristics of the MPRs under a combination of the mentioned advanced materials. [11][12][13][14][15][16] Overall, researchers have stressed the improvement of the development process of interface characteristics and functions (such as substance encapsulation and controlled release) by providing novel technical innovations in every aspect to support biomedical clinical applications related to cells and drugs. Recently, the types, preparation methods, and biomedical applications of MPRs have been systematically presented in several excellent reviews. [3][4][5][8][9][10][17][18][19][20] The thermodynamic properties of liquid-liquid droplet reactors have been analyzed more specifically in some reviews. [7,17] However, the origin of interface characteristics of MPRs, as well as the function and cuttingedge cell-and drug-related biomedical applications determined by the interface characteristics, are deficient in a systematic summary. This review highlights that different emulsion templates endow the inherent interface characteristics of MPRs. Besides, the methods of converting emulsion templates into MPRs are summarized by introducing specific functional biomaterials, followed by the flexible and adjustable interface characteristics expanded by the mentioned materials. Moreover, the biomedical applications related to cells and drugs are analyzed based on the mentioned unique interface characteristics of the MPRs. Furthermore, the existing challenges regarding the current status are presented, and the subsequent development of the MPRs is illustrated from various perspectives (Scheme 1).

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Anisotropic Microparticles from Microfluidics

Cited by 70 publications

References 179 publications

Biopolymer‐Based Multilayer Microparticles for Probiotic Delivery to Colon

Biopolymer‐Based Multilayer Microparticles for Probiotic Delivery to Colon

Biomaterials for microfluidic technology

Microfluidic Particle Reactors: From Interface Characteristics to Cells and Drugs Related Biomedical Applications

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