We study the Cosmic Microwave Background (CMB) anisotropies produced by cosine-type quintessence models. In our analysis, effects of the adiabatic and isocurvature fluctuations are both taken into account. For purely adiabatic fluctuations with scale invariant spectrum, we obtain a stringent constraint on the model parameters using the CMB data from COBE, BOOMERanG and MAXIMA. Furthermore, it is shown that isocurvature fluctuations have significant effects on the CMB angular power spectrum at low multipoles in some parameter space, which may be detectable in future satellite experiments. Such a signal may be used to test the cosine-type quintessence models.