Anisotropy of Callosal Motor Fibers in Combination With Transcranial Magnetic Stimulation in the Course of Motor Development

Koerte, Inga K.; Heinen, Florian; Fuchs, Tobias; Laubender, Ruediger Paul; Pomschar, Andreas; Stahl, Robert; Berweck, Steffen; Winkler, Peter; Hufschmidt, Andreas; Reiser, Maximilian; Ertl‐Wagner, Birgit

doi:10.1097/rli.0b013e31819e9362

Cited by 40 publications

(40 citation statements)

References 35 publications

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“…Similarly, a positive relationship between interhemispheric inhibition (assessed by iSP area and duration) and callosal microstructure across development (range: ~7–26 yrs. ; Koerte et al, 2009) has been shown. However, further analysis of Koerte and colleagues’ dataset is warranted; it is clear that the observed relationship is strongly driven by the child group in their study (mean age: 8.4 yrs).…”

Section: Introductionmentioning

confidence: 92%

Transcallosal sensorimotor fiber tract structure‐function relationships

Fling

Benson

Seidler

2011

Human Brain Mapping

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Recent studies have demonstrated neuroanatomically selective relationships between white matter tract microstructure, physiological function and task performance. Such findings suggest that the microstructure of transcallosal motor fibers may reflect the capacity for interhemispheric inhibition between the primary motor cortices, although full characterization of the transcallosal inhibitory sensorimotor network is lacking. Thus, the goal of the current study was to provide a comprehensive description of transcallosal fibers connecting homologous sensorimotor cortical regions and to identify the relationship(s) between fiber tract microstructure and interhemispheric inhibition during voluntary cortical activity. To this end, we assessed microstructure of fiber tracts connecting homologous sensorimotor regions of the cortex with diffusion tensor imaging. We also assessed interhemispheric inhibition by eliciting the ipsilateral silent period (iSP) within the same participants. We mapped mutually exclusive transcallosal connections between homologous sensorimotor regions and computed quantitative metrics of each fiber tract. Paralleling work in non-human primates we found the densest interhemispheric sensorimotor connections to be between the medial motor areas. Additionally, we provide a mid-sagittal callosal atlas in normalized MNI space for future studies to use when investigating callosal fiber tracts connecting primary and secondary sensorimotor cortices. Finally, we report a strong, positive relationship (r = 0.76) between strength of interhemispheric inhibition (iSP) and microstructure of interhemispheric fibers that is specific to tracts connecting the primary motor cortices. Thus, increased fiber microstructure in young adults predicts interhemispheric inhibitory capacity.

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Section: Introductionmentioning

confidence: 92%

Transcallosal sensorimotor fiber tract structure‐function relationships

Fling

Benson

Seidler

2011

Human Brain Mapping

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“…Poorer motor performance is reported in individuals with compromised inhibitory capacity such as children with premyelinated interhemispheric fibers [11] or patients with multiple sclerosis [12]. On the other hand, IHI is also reduced in musicians (experts in manual motor control) compared to non-musicians [5, 13], and studies demonstrate that IHI is decreased with a concomitant improvement in bimanual motor control following brief training interventions [6,14].…”

Section: Introductionmentioning

confidence: 99%

Task-dependent effects of interhemispheric inhibition on motor control

Fling

Seidler

2012

Behavioural Brain Research

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Interhemispheric communication consists of a complex balance of facilitation and inhibition that is modulated in a task-dependent manner. However, it remains unclear how individual differences in interhemispheric interactions relate to motor performance. To assess interhemispheric inhibition, we utilized the ipsilateral silent period technique (iSP; evoked by suprathreshold transcranial magnetic stimulation), which elicits inhibition of volitional motor activity. Participants performed three force production tasks: 1) unimanual (right hand) constant force, 2) bimanual constant force, (bimanual simultaneous) and 3) bimanual with right hand constant force and left hand sine wave tracking (bimanual independent). We found that individuals with greater IHI capacity demonstrated reduced mirror EMG activity in the left hand during unimanual right hand contraction. However, these same individuals demonstrated the poorest performance during the bimanual independent force production task. We suggest that a high capacity for IHI from one motor cortex to another can effectively prevent “motor overflow” during unimanual tasks, but it can also limit interhemispheric cooperation during independently controlled bimanual tasks.

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“…6,7 Physiologic myelination is known to expand well into early adulthood in conjunction with cognitive, behavioral, emotional, and motor development. [8][9][10] Any pathology interfering with this process of myelination is likely to affect white matter integrity as has been shown in hypoxic-ischemic encephalopathy, former premature in-fants, and normal-pressure hydrocephalus. 11 The onset of childhood MS occurs within this vulnerable period of central nervous system maturation.…”

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confidence: 99%