Ankaferd blood stopper enhances healing after osseous grafting in patients with intrabony periodontal defects

Pamuk, Ferda; Çetinkaya, Burcu Özkan; Keleş, Gonca Çayır; Ballı, Umut; Koyuncuoğlu, Cenker Zeki; Çintan, Serdar; Kantarcı, Alpdoğan

doi:10.1111/jre.12334

Cited by 13 publications

(14 citation statements)

References 62 publications

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“…One possible factor which could explain this result can be attributed to that, ABS hasn't affected on soft tissue parameters This result are consistent with Pamuk, et al in 2016. who explained the clinical efficacy of (ABS) when used in combination with autogenous cortical bone graft (ACB) in the treatment of intrabony periodontal defects. The authors stated that no significant differences in PI, GI, PPD observed between the groups (16) . GÜL, et al explained effect of ABS on bone healing.…”

Section: Discussionmentioning

confidence: 94%

Efficacy of ankaferd blood stopper on healing after osseous grafting in the treatment of periodontal intrabony defects.

ELmohamady

Fikry

2020

Al-Azhar Journal of Dental Science

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Objective: Periodontal diseases are multifactorial infections that lead to destruction of the periodontal structures, including the tooth supporting tissues, periodontal ligament, and alveolar bone. The present study was designed to verify effect of Ankaferd Blood Stopper® (ABS) in conjunction with β tricalcium phosphate (β-TCP) on healing of periodontal intrabony defects. Subjects and Methods: A total of 20 intrabony periodontal defects were treated in ten patients with periodontal pocket depth (PPD) ≥ 6 mm and radiographic osseous defect depth ≥ 4 mm. The split mouth design was performed; In the 1st group (control group) ten defects were treated by β-TCP, while in the 2nd group (test group) ten defects were treated by mixing 0.5 ml of ABS with β-TCP. Phase I therapy was completed for all chosen patients to provide an oral environment more favorable for wound healing. Plaque index (PI), Gingival index (GI), Periodontal pocket depth (PPD) and clinical attachment level (CAL) were assessed for all patients. All indices were recorded at baseline, 6 and 12 months after surgery by the same operator. Radiographic measurements of bone density, M-D width of the defect and depth of the defect (DB) were also performed at the same time periods of recording the clinical parameters. Results: β-TCP/ABS group showed less mean plaque index, gingival index, clinical attachment loss, M-D width of the defect , depth of the defect and higher mean bone density than β-TCP group. Conclusion: Both treatment modalities demonstrated minimal inflammatory signs around teeth. Ankaferd Blood Stopper® combined with Beta tricalcium phosphate may enhance the healing and regenerative processes and lead to more bone fill, as well as density, compared to β tricalcium phosphate alone.

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Section: Discussionmentioning

confidence: 94%

Efficacy of ankaferd blood stopper on healing after osseous grafting in the treatment of periodontal intrabony defects.

ELmohamady

Fikry

2020

Al-Azhar Journal of Dental Science

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“…Pellati et al (2009) and Motsei et al (2003) also demonstrated that 18-beta glycyrrhetinic acid, the key components of ABS, is known to possess a strong antifungal effect on the Candida albicans [36,37]. This property can be utilized for preparing various antifungal mouthwashes for the treatment of oral candidiasis and other fungal infections [47][48][49][50][51][52]. Therefore ABS should be tried as an antiplaque and anti-gingivitis agent for the treatment of gingivitis, periodontitis, periapical, periodontal abscess and postoperative infections following periodontal surgery.…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

“…Pamuk et al (2016) compared the clinical efficacy and expression of Vascular Endothelial-derived Growth Factor (VEGF) upon the use of ABS in combination with autogenous cortical bone graft for the treatment periodontitis induced intra-osseous defects [51]. There was a significant increase in the VEGF concentration when ABS was used along with bone graft as compared to bone graft alone.…”

Section: Regenerative and Anti-apoptotic Propertiesmentioning

confidence: 99%

Ankaferd blood stopper: A novel hemostatic agent with unique antimicrobial, antineoplastic and regenerative properties

Chopra

Sivaraman²

2019

jrp

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A folkloric herbal extract of five plants (Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica), is emerging as a promising hemostatic agent with strong immunological, antiinflammatory, antimicrobial, anti-mutagenic, and antioxidant properties. Though its use as a hemostatic agent in the various general surgical procedure involving gastrointestinal, variceal, presacral bleeding, burns, and epistaxis, etc. is established, very little data comprehensively highlights the mechanisms and clinical application of this potential folkloric combination. The present paper aims to highlight the mechanism of this unique herbal combination with the aim to lay the foundation for further research using this novel hemostatic agent.

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“…It has been used for centuries in Turkish traditional medicine as a hemostatic agent [4]. ABS has been approved by the Turkish Ministry of Health as a topical hemostatic agent for the management of dermal, external, internal, postoperative, and dental bleeding [14,26,31]. It has been manufactured in buffer, ampoule and spray forms since 2007 [5].…”

Section: Introductionmentioning

confidence: 99%

Degenerative effect of Ankaferd Blood Stopper® on mice peripheral sensory neurons in vitro

Üstün¹,

Oğuz²

2018

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A b s t r a c tAnkaferd Blood Stopper ® (ABS) is a licensed medicinal herbal extract that ensures effective hemostasis on external, internal, postoperative and dental bleeds. Dorsal root ganglia (DRG) harbor cell bodies of peripheral sensory neurons. DRG neurons receive peripheral information and regularly send projections to nuclei in the brainstem and the spinal cord. These neurons play critical roles in neural development. Neuronal dysfunctions were reported due to ABS use in surgical interventions. The purpose of this experiment was to investigate the degenerative effects of the ABS on mice DRG cells in vitro. DRG neurons were isolated from adult mice and cultured in vitro. The neurons were incubated with various concentrations of ABS for 24 h. At the end of 24 hours, under fluorescence microscopy, cell viability was determined with the fluorescent dye calcein-AM, and cell death was determined with the fluorescent dye propidium iodide. The behavior of the cells was displayed with time-lapse video microscopy for 12 hours from the time of treatment. ABS killed both neurons and non-neuronal cells via necrosis at a concentration of 25 μl/ml or more. ABS has the degenerative effect on mice peripheral sensory neurons, depending on the ABS level.

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Ankaferd blood stopper enhances healing after osseous grafting in patients with intrabony periodontal defects

Abstract: The findings suggest that ABS enhances the soft tissue healing during the periodontal defect fill by the ACB by stimulating angiogenesis and vascular endothelial cell function, prevents GR and thereby increases the clinical attachment gain.

Cited by 13 publications

References 62 publications

Efficacy of ankaferd blood stopper on healing after osseous grafting in the treatment of periodontal intrabony defects.

Efficacy of ankaferd blood stopper on healing after osseous grafting in the treatment of periodontal intrabony defects.

Ankaferd blood stopper: A novel hemostatic agent with unique antimicrobial, antineoplastic and regenerative properties

Degenerative effect of Ankaferd Blood Stopper® on mice peripheral sensory neurons in vitro

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