Ankaferd Blood Stopper with antibiofilm potential successfully inhibits the extracellular  matrix degradation enzymes and promotes wound healing of 3T3 fibroblasts in vitro

Boran, Rukiye; Baygar, Tuba; Uğur, Aysel

doi:10.3906/sag-1712-80

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…Another study showed that local ABS decreased the macrophage level after sleeve gastrectomy in rats [35]. Boran et al showed that ABS increased fibroblasts in the wound area with chemotactic activity [12]. In our study, the three-fold increase in fibroblasts in the ABS group relative 4.…”

Section: Discussionsupporting

confidence: 50%

“…The effect of Ankaferd starts rapidly, and the encapsulated protein network formation, which is formed by the combination of erythrocyte and blood proteins, occurs in less than a second [14]. The hemostatic, antimicrobial, antiinflammatory, regenerative, antioxidant, antiapoptotic, and antitumoral effects of ABS have been investigated in in vivo and in vitro studies [10][11][12][13][14][24][25][26][27]. In a study by Büyüktiryaki et al, ABS decreased the intestinal necrosis in a necrotizing enterocolitis rat model [28].…”

Section: Discussionmentioning

confidence: 99%

“…ABS has been approved for the management of external hemorrhage and dental surgery by the Ministry of Health in Turkey [9]. ABS is a promising hemostatic and possesses regenerative, antineoplastic, and antimicrobial properties against multidrug resistant bacteria [10][11][12]. ABS is a hemostatic agent used to control postoperative bleeding in patients with various bleeding disorders [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Hancıoğlu¹,

Demirel²,

Bıçakçı³

et al. 2020

Turk J Med Sci

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Background/aim To evaluate the histopathological and mechanical effects of Ankaferd Blood Stopper (ABS) application on wound healing. Materials and methods A total of 24 Wistar albino rats were randomly divided into three equal groups. In each group, a 3 cm-long midline vertical skin incision was performed in the back of the rats. In Group 1, the incision was sutured primarily. In Group 2, incision was left to secondary healing. In Group 3, ABS was applied to the incision. On the 10th day, burst pressure width was measured, and rats were sacrificed. The tissue samples were examined histopathologically. Statistical analysis was conducted with IBM SPSS program. P < 0.05 was considered significant. Results The mean burst pressure widths of wound separation were 13.66 ± 0.457, 7.18 ± 2.599, and 13.66 ± 1.11 mm for Groups 1–3, respectively. The difference in burst pressure width between Groups 1 and 3 was not significant (P > 0.05) but was significant between Groups 2 and 3 (P = 0.000). The vascular proliferation median values were 1, 2, and 2, for Groups 1–3, respectively. Although the difference was significant between Groups 1 and 2 in terms of vascular proliferation score (P = 0.047), no significant difference was observed between Group 3 and others. No statistically significant difference was observed among the groups in terms of collagen score, mononuclear cell infiltration, and polymorphonuclear cell proliferation (P > 0.05). The median values of fibroblast proliferation score were 1, 2, and 3, in Groups 1–3, respectively. Fibroblast proliferation score significantly differed between Groups 1 and 3 (P = 0.003). Conclusion ABS application results in a clean wound healing that is as strong as primary repair. However, additional studies are required to evaluate the late results of increased fibroblastic activity in the early period of ABS application alone.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Hancıoğlu¹,

Demirel²,

Bıçakçı³

et al. 2020

Turk J Med Sci

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“…ABS can improve the wound-healing process via providing inhibition of extra cellular matrix-degrading enzymes during wound repair. Moreover, ABS enhanced the stimulated migration of 3T3 fibroblasts to an artificial wounded area [59]. Plant extracts in ABS have been reported to inhibit various enzymes.…”

Section: The Usage Of Abs In Wound Healingmentioning

confidence: 95%

Ankaferd hemostat: from molecules to medicine

Çiftçiler

Haznedaroğlu

2020

Turk J Med Sci

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Ankaferd hemostat (ABS; Ankaferd Blood Stopper®, İstanbul, Turkey) is a hemostatic agent having an impact on red blood cell–fibrinogen interactions. The hemostatic effect of ABS depends upon the quick promotion of a protein network, particularly fibrinogen gamma, in relation to the erythrocyte aggregation. The entire physiological process involves ABS-induced formation of the protein network by vital erythrocyte aggregation. Vital erythrocyte aggregation occurs with the spectrine, ankyrin, and actin proteins on the membrane of the red blood cells. ABS notably affects cell metabolism and cell cycle mechanisms. Meanwhile, ABS has antiproliferative effects on cancer cells. The aim of this review is to assess molecular basis of ABS as a hemostatic drug. The literature search on ABS was performed in PubMed, Web of Science (SCI expanded), and Scopus with particular focus on the studies of molecular basis of ABS, in vivo research, case series, and controlled randomized clinical studies. Current perspective for the utilization of ABS is to provide hemostasis with accelerating wound healing. Future controlled trials are needed to elucidate the pleiotropic clinical effects of ABS such as antineoplastic, antiinflammatory, antiinfective, antifungal, and antioxidative effects.

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Potential and Prophylactic Use of Plants Containing Saponin-Type Compounds as Antibiofilm Agents against Respiratory Tract Infections

Cankaya

Somuncuoglu

2021

Evidence-Based Complementary and Alternative Medicine

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Epidemic diseases have been observed in every period of human history, and the treatment process has taken time. Causative microorganisms reproduce as biofilm and contribute to the emergence of various infectious diseases. The process that starts with respiratory disorders causes serious lung infections due to bacteria and viruses that accumulate and multiply. The biofilms are difficult to eliminate and show increased resistance to available antimicrobial agents. There is a need to identify and develop potential resources used in treatment. The search for novel biological agents from plants is gaining popularity due to the high abundance, accessibility with consequent lower cost for discovery, and lesser side effects and toxicity. Saponins found in some plants can be alternative to antibiotics, with antimicrobial activities. This review focused on the potency of saponin-containing plants with antimicrobial properties as antibiofilm agents against these infections. For this purpose, keywords were scanned in Web of Science, Scopus, and Google academics databases, and the related literature was compiled. Approximately, 25 plant taxa belonging to 18 families traditionally used in the treatment of respiratory diseases are listed. These taxa mostly belong to Fabaceae, Asteraceae, Apiaceae, and Asparagaceae families, respectively. Most of these taxa have antibacterial, antifungal, antitussive, and anti-inflammatory activities. Especially, plants with antibiofilm activity that can be effective against many microorganisms are compiled in this study. These plants can prevent or treat upper respiratory tract diseases caused by bacteria due to the phytochemicals they contain, especially saponins.

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Ankaferd Blood Stopper with antibiofilm potential successfully inhibits the extracellular matrix degradation enzymes and promotes wound healing of 3T3 fibroblasts in vitro

Cited by 5 publications

References 36 publications

Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Ankaferd hemostat: from molecules to medicine

Potential and Prophylactic Use of Plants Containing Saponin-Type Compounds as Antibiofilm Agents against Respiratory Tract Infections

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