Ankle Fractures Treated Using Biodegradable Internal Fixation

Böstman, O; Hirvensalo, Eero; Vainionpää, S.; Mäkelä, Antero; Vihtonen, Kimmo; Törmälä, P.; Rokkanen, P

doi:10.1097/00003086-198901000-00028

Cited by 164 publications

(62 citation statements)

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“…Bioabsorbable implants have been shown to provoke an adverse tissue response characterized as an inflammatory, abacterial, foreign-body reaction [2][3][4]. This reaction represents an inherent biologic tissue response to implant degradation and absorption [5,28].…”

Section: Discussionmentioning

confidence: 99%

Delayed Foreign-body Reaction to Absorbable Implants in Metacarpal Fracture Treatment

Givissis

Stavridis

Papagelopoulos

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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Background First-generation bioabsorbable implants have been associated with a high complication rate attributable to weak mechanical properties and rapid degradation. This has led to the development of stronger devices with improved durability. However, the modern implants have raised concerns about potential late-occurring adverse reactions. Questions/purposes This retrospective study addressed the following questions: Can absorbable implants consisting of trimethylene carbonate, L-lactide, and D,L-lactide provide adequate fixation for healing of a metacarpal fracture? Will these implants obviate a second removal operation? What complications can occur in the reaction to implant breakdown? Patients and Methods Twelve unstable, displaced, metacarpal fractures were studied in 10 consecutive patients (seven men, three women; mean age, 36.4 years; range, 18-75 years). The fractures were treated with absorbable plates and screws consisting of the aforementioned copolymers and designed to resorb in 2 to 4 years. Nine patients (10 fractures) were available for clinical and radiographic followups (mean, 45.7 months; range, 34-61 months).

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Section: Discussionmentioning

confidence: 99%

Delayed Foreign-body Reaction to Absorbable Implants in Metacarpal Fracture Treatment

Givissis

Stavridis

Papagelopoulos

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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“…Majola et al [99] reported that PLA rods had good biocompatibility in the cancellous bone of rats. Böstman et al [92] also reported the biocompatibility of PLA copolymers in the human body. They found that 6 out of 120 patients treated with pins fabricated from a PLA-PGA copolymer developed an aseptic sinus at the implantation site.…”

Section: Orthopedic Devicementioning

confidence: 97%

“…These types of absorbable screws and pins have been gaining the widespread clinical use, particularly in cases where high mechanical stiffness or strength was not required. Pertinent orthopedic areas might include the knee [89][90][91], shoulder, foot and ankle [92][93][94], hand, wrist [95], elbow [96], pelvis, and zygomatic fractures. In some cases, high performance PLA was needed, so that techniques would be used to improve the mechanical properties of PLA, particularly impact strength, tensile strength, and flexural strength in fracture fixation, where both metal and biodegradable plate, pins, and rods had limits in their use in fracture fixation.…”

Section: Orthopedic Devicementioning

confidence: 99%

Properties and medical applications of polylactic acid: A review

Hamad¹,

Kaseem²,

Yang

et al. 2015

Express Polym. Lett.

602

306

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Abstract. Polylactic acid (PLA), one of the well-known biodegradable polyesters, has been studied extensively for tissue engineering and drug delivery systems, and it was also used widely in human medicine. A new method to synthesize PLA (ring-opening polymerization), which allowed the economical production of a high molecular weight PLA polymer, broadened its applications, and this processing would be a potential substitute for petroleum-based products. This review described the principles of the polymerization reactions of PLA and, then, outlined the various materials properties affecting the performance of PLA polymer, such as rheological, mechanical, thermal, and barrier properties as well as the processing technologies which were used to fabricate products based on PLA. In addition, the biodegradation processes of products which were shaped from PLA were discussed and reviewed. The potential applications of PLA in the medical fields, such as tissue engineering, wound management, drugs delivery, and orthopedic devices, were also highlighted.

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“…Natural polymer such as chitosan, alginate or gelatin [15][16][17] or synthetic polymer such as poly lactic acid (PLA), poly glycolic acid(PGA) an poly lactic -co-glycolic acid (PLGA) are widely used for polymer scaffold. However, some drawbacks still exist upon using polymers including: formation of acidic species, this leads to a decrease in pH and tissue inflammation [18,19]. Among several choices of polymers, poly (vinyl alcohol) (PVA), a hydrophilic semicrystalline polymer, has been frequently explored as an implant material in wide array of biomedical applications such as drug delivery systems, wound dressings, membranes, surgical repairs and artificial skin, mainly due to its excellent mechanical strength, biocompatibility, and nontoxicity [15,16].…”

Section: Introductionmentioning

confidence: 99%

Effect of ciprofloxacin incorporation in PVA and PVA bioactive glass composite scaffolds

Mabrouk

Mostafa

Oudadesse

et al. 2014

Ceramics International

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Scaffolds are implants used to deliver cells, drugs, and genes into the body in a local controlled release pattern which offers many advantages over systematic drug delivery. Composite scaffolds of polyvinyl alcohol (PVA) and quaternary bioactive glass (46S6 system) with different ratios of glass contents were prepared by lyophilisation technique. The broad spectrum antibiotic ciprofloxacin (Cip) was impregnated to the scaffold during the fabrication in a concentration of 5, 10 and 20%. Biodegradation rate and in-vitro mineralization of the prepared scaffolds were performed by soaking the scaffolds in simulated body fluid (SBF). Phase identification, microstructure, porosity, bioactivity, mechanical properties and drug release pattern in PBS were characterized by XRD, SEM coupled with EDS, Hg-porosimeter, inductively coupled plasma-optical emission spectroscopy (ICP-OES), universal testing machine, fourier transform infrared (FTIR) and UV-spectrophotometer, respectively. A porous scaffold has been obtained with porosity up to 85%. By increasing the glass contents in the prepared scaffold the porosity and the degradation rate decrease however, the compressive strength was enhanced. A sustained drug release pattern was observed with a quasi-Fickian diffusion mechanism. The formulated ciprofloxacin loaded porous polyvinyl alcohol scaffold gave an acceptable physicochemical properties and was able to deliver the drug in a prolonged release pattern which offers a distinguish treatment for osteomylitis as well as local antibacterial effect.

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Ankle Fractures Treated Using Biodegradable Internal Fixation

Cited by 164 publications

References 0 publications

Delayed Foreign-body Reaction to Absorbable Implants in Metacarpal Fracture Treatment

Delayed Foreign-body Reaction to Absorbable Implants in Metacarpal Fracture Treatment

Properties and medical applications of polylactic acid: A review

Effect of ciprofloxacin incorporation in PVA and PVA bioactive glass composite scaffolds

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