Ankylosing spondylitis disease activity and serum vitamin D levels: A systematic review and meta-analysis

Chen, Menglu; Li, Wen; Li, Lailai; Chai, Yang; Yang, Yuqi; Pu, Xiang

doi:10.1097/md.0000000000031764

Cited by 3 publications

(4 citation statements)

References 42 publications

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“…Vitamin D status has been described to inversely correlate with inflammatory disease but is also an acute phase reactant that drops when tissue injury occurs. Thus, it has been unclear whether a lower vitamin D status in patients with inflammatory diseases, such as has been described in patients r-axSpA [ 44 ], is a causal factor or merely negatively correlated to inflammation for other reasons. Recently, results from a large-scale RCT study ( n = 25.871) on vitamin D supplementation found a decreased incidence of autoimmune diseases [ 45 ] and indications of reduced CRP after 2 but not 4 years [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Patients with radiographic axial spondylarthritis have an impaired dietary intake—a cross-sectional study with matched controls from northern Sweden

Hulander,

Zverkova Sandström,

Beckman Rehnman

et al. 2023

Arthritis Res Ther

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Background Radiographic axial spondyloarthritis (r-axSpA) is one of the most common chronic inflammatory rheumatic diseases, affecting about 0.2% of the Swedish population. Adequate nutritional intake is essential for maintaining physiological functions. A poor diet increases the risk of developing conditions such as obesity, osteoporosis, and/or atherosclerosis. Diet quality is also theorized to affect systemic inflammation. Dietary habits in patients with r-axSpA are largely unknown. The aims of this study were to assess dietary nutrient intake in r-axSpA patients and examine whether it differs compared to persons without r-axSpA. Methods r-axSpA patients (modified NY criteria) at the rheumatology clinic in Region Västerbotten, northern Sweden, were invited to take part in the Backbone study which investigates disease severity and comorbidities. In total, 155 patients were included. Nutritional intake was assessed by the semi-quantitative food frequency questionnaire MiniMeal-Q. Controls were collected from the Swedish CArdioPulmonary bioImage Study (n = 30,154), a study that invited participants 50–64 years of age by random selection from the Swedish population register. Out of the 155 r-axSpA patients, 81 were in the same age span. Four controls were identified for each patient, matched on age (± 1 year), sex, and geographic location. Data on dietary intake was available for 319 controls. Statistical comparisons of dietary intake between patients with r-axSpA and controls were done by exact conditional logistic regression analysis, adjusted for country of birth, educational level, single household, weight, smoking status, and energy intake. Results Patients had a comparatively significantly higher energy intake from carbohydrates, a lower fiber density, and a lower intake of marine omega-3 fatty acids. Furthermore, intake of vitamins D, E, and K as well as selenium, folate, calcium, magnesium, phosphorus, potassium, vitamin A, and β-carotene (a precursor of vitamin A and marker of vegetable and fruit intake) was significantly lower among patients compared to controls. Conclusions Our results suggest that r-axSpA patients have an impaired dietary intake. Notably, intake was lower in several nutrients theorized to have anti-inflammatory properties (fiber density, marine-omega-3 fatty acids, vitamin D, and selenium). We further propose that nutrition screening might be incorporated into the management of r-axSpA patients.

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Section: Discussionmentioning

confidence: 99%

Patients with radiographic axial spondylarthritis have an impaired dietary intake—a cross-sectional study with matched controls from northern Sweden

Hulander,

Zverkova Sandström,

Beckman Rehnman

et al. 2023

Arthritis Res Ther

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“…(20) Se demuestra que la exposición solar es un factor importante en la presencia de vitamina de D, debido que las exacerbaciones de enfermedades autoinmunes como la esclerosis múltiple se da en primavera, incluso al suplementar vitamina D reduce un 40 % de riesgo; (21) se evidenció el mismo en prevenir el desarrollo de AR. (22,23) Por otra parte, el déficit de vitamina D se asociada a espondiloartopatías, por el contrario, Chen M et al (15) reportaron correlación negativa entre los niveles séricos de Vitamina D y espondiloartopatías. Zagar I (24) y Ben-shaat et al (16) afirman que estos niveles bajos se correlacionan también con un aumento en el riesgo de la mortalidad en pacientes que padecen de espondilitis anquilosante sumando todas las causas aliadas a esta enfermedad.…”

Section: Discussionunclassified

“…Chen M et al (15) 2022 6 Vitamina D2/D3 "Índice de actividad de la enfermedad" (Fisher: -0,34) "Velocidad de sedimentación globular" (Fisher: -0,38) "Proteína C" (PCR) (Fisher:…”

Section: No Especificadosunclassified

“…Bien tolerada, no se reportaron efectos secundarios La asociación de la vitamina D con espondiloartopatías con respecto a los indicadores para seguimiento de la enfermedad no se encuentran relacionados a los niveles séricos de vitamina D. (15) Por otro lado, la disminución de los valores de vitamina D no tiene relación con la actividad o comportamiento de la espondilitis anquilosante sin embargo estos niveles se encuentran vinculados a un alto riesgo de mortalidad junto a otras causas de la enfermedad. (15,16) Con respecto a su asociación con fármacos se reveló que la combinación con alendronato no puede usarse para tratar la pérdida ósea, ni mejorar la validad de vida, por otro lado, la combinación con bisfosfonatos mejora la densidad mineral ósea en la columna lumbar. (16,17,18)…”

Section: Incremento De Niveles De Esclerósica Causa Aumento De Il-23unclassified

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Role of vitamin D in autoimmune rheumatological diseases

Centeno

Aguinsaca

Yunga

et al. 2023

Salud, Ciencia y Tecnología

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Introduction: Vitamin D is a hormone synthesized in the skin, by the presence of the "precursor molecule 7-dehicrocholesterol" whose action depends directly on the stimulus of ultraviolet rays for the production of cholecalciferol. It has several functions including a fundamental role in mediating the response of the immune system, plays modulatory actions, counteracts inflammatory, oxidative and fibrotic activity, and consequently regulates autoimmune tissue lesions. As it possesses an immunomodulatory property, is related to the appearance and progression of autoimmune disorders. Objective: To describe the role of vitamin D in autoimmune rheumatologic diseases. Methods: A narrative review was performed, collecting information from January 2019 to January 2023 in scientific databases such as: Pubmed, Scopus, Web of Science, and Google Scholar, using keywords. Results: Vitamin D in autoimmune rheumatic diseases influences the control and decrease of inflammatory activity, slows its speed of progression and improves clinical manifestations, although there is no total consensus on the mode of use, however, its supplementation has a great benefit. Conclusions: The role of Vitamin D in autoimmune rheumatic diseases varies according to the underlying pathology, in combination with bisphosphonates it can improve bone mineral density in spondyloarthropathies, prevent osteoporosis, improve the clinical picture of SLE and Systemic Sclerosis, but it can increase antibody levels in Connective Tissue Diseases.

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Environmental and Genetic Determinants of Ankylosing Spondylitis

Bilski,

Kamiński,

Kupczyk

et al. 2024

IJMS

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Exposure to heavy metals and lifestyle factors like smoking contribute to the production of free oxygen radicals. This fact, combined with a lowered total antioxidant status, can induce even more damage in the development of ankylosing spondylitis (AS). Despite the fact that some researchers are looking for more genetic factors underlying AS, most studies focus on polymorphisms within the genes encoding the human leukocyte antigen (HLA) system. The biggest challenge is finding the effective treatment of the disease. Genetic factors and the influence of oxidative stress, mineral metabolism disorders, microbiota, and tobacco smoking seem to be of great importance for the development of AS. The data contained in this review constitute valuable information and encourage the initiation and development of research in this area, showing connections between inflammatory disorders leading to the pathogenesis of AS and selected environmental and genetic factors.

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Ankylosing spondylitis disease activity and serum vitamin D levels: A systematic review and meta-analysis

Cited by 3 publications

References 42 publications

Patients with radiographic axial spondylarthritis have an impaired dietary intake—a cross-sectional study with matched controls from northern Sweden

Patients with radiographic axial spondylarthritis have an impaired dietary intake—a cross-sectional study with matched controls from northern Sweden

Role of vitamin D in autoimmune rheumatological diseases

Environmental and Genetic Determinants of Ankylosing Spondylitis

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