Ankylosing Spondylitis Is Associated With Risk of New-Onset Obstructive Sleep Apnea: A Nationwide Population-Based Cohort Study

Tsao, Chien‐Han; Huang, Jing‐Yang; Huang, Hsin-Hsin; Hung, Yao-Min; Wei, James Cheng‐Chung; Hung, Yin-Tsan

doi:10.3389/fmed.2019.00285

Cited by 5 publications

(4 citation statements)

References 45 publications

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“…Ankylosing Spondylitis is a chronic inflammatory disease that has a negative effect on the quality of life [21]. The findings of previous studies indicate the existence of disorders in the quality, duration, and efficiency of sleep, difficulties in falling asleep, the presence of restless leg syndrome, and obstructive sleep apnea among AS patients [37,38,[46][47][48][49].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of sleep disturbance in patients with ankylosing spondylitis: a systematic review and meta-analysis

et al. 2023

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Background Ankylosing Spondylitis (AS) patients face several challenges due to the nature of the disease and its physical and psychological complications. Sleep disorders are among the most important concerns. Sleep disorders can aggravate the signs and symptoms of the disease and ultimately reduce the quality of patients’ lives. This study uses a systematic review and meta-analysis to pool the reported prevalence of sleep disorders among AS patients. Methods To find related studies, the WoS, PubMed, ScienceDirect, Scopus, Embase, and Google Scholar databases were systematically searched without a lower time limit. Heterogeneity among the identified studies was checked using the I2 index, and the Begg and Mazumdar correlation test examined the existence of published bias. Comprehensive Meta-Analysis (v.2) software was adopted to analyze the data. Results In the review of 18 studies with a sample size of 5,840, the overall pooled prevalence of sleep disorders among AS patients based on the random effects method was found to be 53% (95% CI: 44.9–61). The highest and lowest prevalence was in Egypt at 90% and Australia at 19.2%, respectively. Our meta-regression results show that with the increase in ‘sample size’ and ‘year of publication’, the overall prevalence of sleep disorders in patients with AS decreases (p < 0.05). Conclusion The results of the present study indicate a high and significant prevalence of sleep disorders among AS patients. Thus, health policymakers and healthcare providers must focus on timely diagnosis and effective educational and therapeutic interventions for the prevention and proper treatment of sleep disorders in this population of patients.

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Section: Discussionmentioning

confidence: 99%

Prevalence of sleep disturbance in patients with ankylosing spondylitis: a systematic review and meta-analysis

et al. 2023

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“…Obstructive sleep apnea (OSA) is an important sleep disorder that has been reported in individuals with rheumatological diseases, including SLE [ 16 , 17 , 18 ]. OSA is characterized by repeated episodes of upper airway collapse and obstruction during sleep associated with multiple sleep arousals and intermittent hypoxia.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, there is inconsistency in the current literature regarding the prevalence of OSA in ankylosing spondylitis. While some studies support the association between OSA and ankylosing spondylitis [ 18 , 24 ], others fail to establish a significant association between the two [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association

Meidan

Elalouf

Tauman

et al. 2023

Life

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Marked fatigue is common in patients with systemic lupus erythematosus (SLE). This study aimed to assess the association of sleep disorders, including obstructive sleep apnea (OSA), with SLE. Forty-two consecutive patients with SLE and 20 healthy controls were recruited and underwent a one-night ambulatory sleep examination. They completed questionnaires, including the Pittsburgh Sleep Quality Index (PSQI) and Functional Assessment of Chronic Illness Therapy (FACIT). SLE disease activity and damage were assessed by the SLE Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI). A significantly increased apnea/hypopnea index was noted in the SLE group compared to healthy controls (p = 0.004). SLE patients had higher rates of moderate-to-severe OSA (p = 0.04), PSQI (p = 0.001), and FACIT scores (p = 0.0008). Multivariate analysis revealed that the SDI was associated with OSA (p = 0.03). There was a positive association between SLEDAI-2K and moderate-to-severe OSA (p = 0.03). Patients with SLE had an increased prevalence of OSA and poorer quality of sleep compared to healthy controls. Our findings suggest that active disease and accumulated damage may be associated with OSA. These findings highlight the importance of identifying the presence of OSA in patients with SLE.

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“…Morning stiffness, difficulty waking up, limited chest expansion, or obstructive sleep apnea syndrome (OSA) may lead to sleep disorders. Indeed, the incidence of OSA in AS patients is three times more frequent than in the general population [ 2 ]. A restriction of the oropharyngeal airway because of temporomandibular joint involvement, or ossification of the anterior longitudinal ligament may cause the latter [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Factors associated with the inflammatory process in pain in ankylosing spondylitis

Maatallah¹,

Yasmine²,

Ferjani³

et al. 2022

Pan Afr Med J

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Introduction sleep disorders, closely related to any chronic pain process, are frequent among patients with rheumatic diseases, mainly ankylosing spondylitis (AS). Our study aimed to determine the association between sleep disturbances and the inflammatory process in pain in AS patients compared with lower back pain (LBP) patients. We have additionally examined factors associated with sleep disorders among AS patients. Methods we conducted a cross-sectional study among AS patients. Sociodemographic data, patient reported outcomes and disease characteristics were recorded. Sleep was assessed using the medical outcomes study sleep scale measure (MOS-SS). For psychological assessment, Beck anxiety (BAI) and depression index (BDI) was used. A multivariate logistic regression was performed to identify factors associated with sleep disorders. Results the study included 50 patients with AS and 40 patients with low back pain. The most common affected domains among AS patients were inadequacy, sleep disturbance, and daily somnolence. The MOS-SS index was significantly higher in the AS group than in the control group (p<0.001). Sleep disorder was associated with age, female gender, analphabetism, patient-reported outcomes (all p<0.05), but was not associated with profession, comorbidities and smoking habits. In multivariate analysis, factors associated with sleep disruption were the duration of morning stiffness (MS), disease activity, bath ankylosing spondylitis metrology index (BASMI), ASQol, as well as anxiety and depression (odds ratio: 5.4(CI 95% 1.6-18.3), 9.9 (CI95%1.1-86); 6 (CI95%1.1-32); 13 (CI 95% 1.4-143.8); 15.7 (CI 95% 2.6-94.3); 14 (CI 95% 2-105.7) respectively, p<0.05 for each). Conclusion our study highlighted the importance of sleep disorders among patients with AS with a predilection for inadequacy, sleep disturbance, and daily somnolence. Factors associated with sleep disruption were high disease activity, a longer duration of MS, an altered function and quality of life as well as anxiety and depression.

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Ankylosing Spondylitis Is Associated With Risk of New-Onset Obstructive Sleep Apnea: A Nationwide Population-Based Cohort Study

Cited by 5 publications

References 45 publications

Prevalence of sleep disturbance in patients with ankylosing spondylitis: a systematic review and meta-analysis

Prevalence of sleep disturbance in patients with ankylosing spondylitis: a systematic review and meta-analysis

Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association

Factors associated with the inflammatory process in pain in ankylosing spondylitis

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