Ankylosing Spondylitis - Recent Concepts 2023
DOI: 10.5772/intechopen.109164
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Ankylosing Spondylitis Pathogenesis and Pathophysiology

Abstract: The pathogenesis and pathophysiology of Ankylosing Spondylitis (AS) is complex and remains only partially understood. Contributory genes including a variety of HLA-B27 subset genes and many other non-HLA genes are implicated in the literature. Novel genes and gene–gene interactions being a continuously evolving area of AS research. Dysregulation of the enteric microbiome with a corresponding aberrant immunological response is recognised in research. Certain infectious agents are thought to play a role. A varie… Show more

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Cited by 3 publications
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“…ultimately, a progressive increase in spinal rigidity resulting in loss of flexibility and movement due to complete fusion of the spine [32]. While the pathophysiology of AS is yet to be elucidated, it is associated with the HLA B27 gene polymorphism [33].…”
Section: Tablementioning
confidence: 99%
“…ultimately, a progressive increase in spinal rigidity resulting in loss of flexibility and movement due to complete fusion of the spine [32]. While the pathophysiology of AS is yet to be elucidated, it is associated with the HLA B27 gene polymorphism [33].…”
Section: Tablementioning
confidence: 99%
“…However, certain factors have been identified to play an essential role in its pathogenesis, including genetics, certain infections, environmental exposure, and sex hormones. Based on emerging evidence, the pathophysiological response in AS has been identified as a combination of auto-inflammatory and autoimmune processes [ 8 ]. AS has a vital genetic component with high monozygotic twin concordance and a high heritability rate of 63% and 90%, respectively [ 9 , 10 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, certain factors have been identified to play an essential part in the process, including genetics, certain infections, environmental exposure, and sex hormones appear to play a role in the pathogenesis. Based on emerging evidence, the pathophysiological response in AS has been identified as a combination of auto-inflammatory and autoimmune processes [8]. AS has a vital genetic component with high monozygotic twin concordance and a high heritability rate of 63% and 90%, respectively [9,10].…”
mentioning
confidence: 99%