Annelation of Drotaverine by p‐Quinones to Form Hydroxyindolo‐ and Hydroxybenzindoloisoquinoline Derivatives.

Abstract

Fused pyridine derivatives R 0450Annelation of Drotaverine by p-Quinones to Form Hydroxyindolo-and Hydroxybenzindoloisoquinoline Derivatives. -The well-known spasmolytic agent drotaverine (I) readily reacts with quinones (II) to form Nenitzescu reaction products, viz. indoloisoquinolines (III), in moderate yield. The compounds (III) are smoothly O-acylated and O-alkylated. Aminomethylation of compound, (IIIb) occurs at the 6-position but fails for compound (IIIa). -(UKHIN*, L. Y.; GRIBANOVA, T. N.; KUZ'MINA, L. G.; Russ. Chem. Bull. 54 (2005) 3, 774-783; Inst. Phys. Org. Chem., Rostov State Univ., Rostov-on-Don 344090, Russia; Eng.) -D. Singer 09-157