Annellation of Triazole and Tetrazole Systems onto Pyrrolo[2,3-d]pyrimidines: Synthesis of Tetrazolo[1,5-c]-pyrrolo[3,2-e]-pyrimidines and Triazolo[1,5-c]pyrrolo-[3,2-e]pyrimidines as Potential Antibacterial Agents

Abstract

Syntheses of several novel 4-chloropyrrolo[2,3-d]pyrimidines (1), 4- hydrazinopyrrolo[2,3-d]pyrimidines (2) and 3-amino-4-iminopyrrolo[2,3-d]pyrimidines (7) and their use in the synthesis of tetrazolo[1,5-c]pyrrolo[3,2-e]pyrimidines (3) and triazolo[1,5-c]pyrrolo[3,2-e]pyrimidines (4) required for biological screening are reported.

Biological Portfolio of 1,5-Disubstituted Tetrazoles: A Review

“…The preliminary bioassay indicated that most target compounds exhibited very good direct anti-TMV activity at 100 mg/mL, which was equal to or higher than that of ribavirin. Among them, compound (19) showed excellent anti-TMV activity with inhibition activity of 48.73%, which was higher than that of ninamycin. …”

3-(4-Bromobenzoyl)prop-2-enoic acid as Precursor in Synthesis of Some Important Heterocyclic Compounds

“…Inteaction of compound 11 with hydrazine hydrate [32] in boiling ethanol yielded 5-(4-bromophenyl)-1,2,3-trihydro-1,2,6,7,9-pentaza-phenalen-3(3H)-one 13, without isolation the hydrazino derivative 12b. This could be explained by the formation of the imino derivative first, which the presence of a base (hydrazine hydrate) underwent a Dimroth rearrangement [33][34][35] to give the thermodynamically more stable hydrazine derivative which underwent ring closure and yielded the desired product 13.…”

Synthesis and Structure Activity Relationship of Some Indole Derivatives as Potential Anti-inflammatory Agents

“…[64][65][66] 3-d]pyrimidines were reported to act as potent anticancer agents, in this work, a series of novel 2-substituted- …”