Annex D. Radiation Effects in Reference Animals and                Plants

doi:10.1016/j.icrp.2009.04.011

Cited by 5 publications

(1 citation statement)

References 168 publications

(170 reference statements)

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“…The two lower dose rates, 0.005 and 0.05 mGy/h, encompass the benchmark dose rate of 0.01 mGy/h recommended for ecosystem radiological protection [26] and were thus defined as low dose rates. The dose rates of 0.5 and 5 mGy/h, in the range of the DCRL [27] where phenotypical effects start to be observed in juvenile fish, were defined here as moderate. Finally, we defined 50 mGy/h, typical of exposures shortly after the Chernobyl accident, as a high dose rate.…”

Section: Introductionmentioning

confidence: 99%

Ionising Radiation Induces Promoter DNA Hypomethylation and Perturbs Transcriptional Activity of Genes Involved in Morphogenesis during Gastrulation in Zebrafish

Houdigui

Adam-Guillermin

Armant

2020

IJMS

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Embryonic development is particularly vulnerable to stress and DNA damage, as mutations can accumulate through cell proliferation in a wide number of cells and organs. However, the biological effects of chronic exposure to ionising radiation (IR) at low and moderate dose rates (< 6 mGy/h) remain largely controversial, raising concerns for environmental protection. The present study focuses on the molecular effects of IR (0.005 to 50 mGy/h) on zebrafish embryos at the gastrula stage (6 hpf), at both the transcriptomics and epigenetics levels. Our results show that exposure to IR modifies the expression of genes involved in mitochondrial activity from 0.5 to 50 mGy/h. In addition, important developmental pathways, namely, the Notch, retinoic acid, BMP and Wnt signalling pathways, were altered at 5 and 50 mGy/h. Transcriptional changes of genes involved in the morphogenesis of the ectoderm and mesoderm were detected at all dose rates, but were prominent from 0.5 to 50 mGy/h. At the epigenetic level, exposure to IR induced a hypomethylation of DNA in the promoter of genes that colocalised with both H3K27me3 and H3Kme4 histone marks and correlated with changes in transcriptional activity. Finally, pathway enrichment analysis demonstrated that the DNA methylation changes occurred in the promoter of important developmental genes, including morphogenesis of the ectoderm and mesoderm. Together, these results show that the transcriptional program regulating morphogenesis in gastrulating embryos was modified at dose rates greater than or equal to 0.5 mGy/h, which might predict potential neurogenesis and somitogenesis defects observed at similar dose rates later in development.

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Section: Introductionmentioning

confidence: 99%

Ionising Radiation Induces Promoter DNA Hypomethylation and Perturbs Transcriptional Activity of Genes Involved in Morphogenesis during Gastrulation in Zebrafish

Houdigui

Adam-Guillermin

Armant

2020

IJMS

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Whole-body to tissue concentration ratios for use in biota dose assessments for animals

Yankovich

Beresford

Wood

et al. 2010

Radiat Environ Biophys

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Environmental monitoring programs often measure contaminant concentrations in animal tissues consumed by humans (e.g., muscle). By comparison, demonstration of the protection of biota from the potential effects of radionuclides involves a comparison of whole-body doses to radiological dose benchmarks. Consequently, methods for deriving whole-body concentration ratios based on tissue-specific data are required to make best use of the available information. This paper provides a series of look-up tables with whole-body:tissue-specific concentration ratios for non-human biota. Focus was placed on relatively broad animal categories (including molluscs, crustaceans, freshwater fishes, marine fishes, amphibians, reptiles, birds and mammals) and commonly measured tissues (specifically, bone, muscle, liver and kidney). Depending upon organism, whole-body to tissue concentration ratios were derived for between 12 and 47 elements. The whole-body to tissue concentration ratios can be used to estimate whole-body concentrations from tissue-specific measurements. However, we recommend that any given whole-body to tissue concentration ratio should not be used if the value falls between 0.75 and 1.5. Instead, a value of one should be assumed.

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Eta-Earth Revisited II: Deriving a Maximum Number of Earth-Like Habitats in the Galactic Disk

Scherf,

Lammer,

Spross

2024

Astrobiology

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Annex D. Radiation Effects in Reference Animals and Plants

Cited by 5 publications

References 168 publications

Ionising Radiation Induces Promoter DNA Hypomethylation and Perturbs Transcriptional Activity of Genes Involved in Morphogenesis during Gastrulation in Zebrafish

Ionising Radiation Induces Promoter DNA Hypomethylation and Perturbs Transcriptional Activity of Genes Involved in Morphogenesis during Gastrulation in Zebrafish

Whole-body to tissue concentration ratios for use in biota dose assessments for animals

Eta-Earth Revisited II: Deriving a Maximum Number of Earth-Like Habitats in the Galactic Disk

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