ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus

Sousa, Stefanie Oliveira de; Santos, Mayk Ricardo dos; Teixeira, Samuel Cota; Ferro, Eloísa Amália Vieira; Oliani, Sônia Maria

doi:10.3390/cells11132057

Cited by 10 publications

(2 citation statements)

References 93 publications

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“…As previously mentioned, APCs interact with dying cancer cells, and ANXA1 is released from dying cancer cells. It binds to the formyl peptide receptor 1 (FPR1) on APCs [ 53 , 54 ]. In other words, ANXA1 mediates the uptake of tumor antigens for presentation [ 55 ].…”

Section: Immunogenic Cell Death: An Innovative Approach To Cancer The...mentioning

confidence: 99%

Stimulators of immunogenic cell death for cancer therapy: focusing on natural compounds

Amiri,

Molavi,

Sabetkam

et al. 2023

Cancer Cell Int

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A growing body of evidence indicates that the anticancer effect of the immune system can be activated by the immunogenic modulation of dying cancer cells. Cancer cell death, as a result of the activation of an immunomodulatory response, is called immunogenic cell death (ICD). This regulated cell death occurs because of increased immunogenicity of cancer cells undergoing ICD. ICD plays a crucial role in stimulating immune system activity in cancer therapy. ICD can therefore be an innovative route to improve anticancer immune responses associated with releasing damage-associated molecular patterns (DAMPs). Several conventional and chemotherapeutics, as well as preclinically investigated compounds from natural sources, possess immunostimulatory properties by ICD induction. Natural compounds have gained much interest in cancer therapy owing to their low toxicity, low cost, and inhibiting cancer cells by interfering with different mechanisms, which are critical in cancer progression. Therefore, identifying natural compounds with ICD-inducing potency presents agents with promising potential in cancer immunotherapy. Naturally derived compounds are believed to act as immunoadjuvants because they elicit cancer stress responses and DAMPs. Acute exposure to DAMP molecules can activate antigen-presenting cells (APCs), such as dendritic cells (DCs), which leads to downstream events by cytotoxic T lymphocytes (CTLs) and natural killer cells (NKs). Natural compounds as inducers of ICD may be an interesting approach to ICD induction; however, parameters that determine whether a compound can be used as an ICD inducer should be elucidated. Here, we aimed to discuss the impact of multiple ICD inducers, mainly focusing on natural agents, including plant-derived, marine molecules, and bacterial-based compounds, on the release of DAMP molecules and the activation of the corresponding signaling cascades triggering immune responses. In addition, the potential of synthetic agents for triggering ICD is also discussed.

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Section: Immunogenic Cell Death: An Innovative Approach To Cancer The...mentioning

confidence: 99%

Stimulators of immunogenic cell death for cancer therapy: focusing on natural compounds

Amiri,

Molavi,

Sabetkam

et al. 2023

Cancer Cell Int

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“…The functions of annexin A1 (ANXA1) have a key role in protecting cells against DNA damage [32,33]. The study by Moreli and colleagues found that, in ANXA1 knockout mice (AnxA1−/−), the labyrinth zone of the placenta was reduced, and there was increased DNA damage, causing apoptosis in the labyrinthine and junctional layers.…”

mentioning

confidence: 99%

Special Issue “Physiology and Pathophysiology of the Placenta”

Tossetta

2024

IJMS

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Neuroprotective effects of annexin A1 tripeptide in rats with sepsis‐associated encephalopathy

Cui,

Qin,

Zhang

et al. 2024

Biotech and App Biochem

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Sepsis‐associated encephalopathy (SAE) is characterized by high incidence and mortality rates, with limited treatment options available. The underlying mechanisms and pathogenesis of SAE remain unclear. Annexin A1 (ANXA1), a membrane‐associated protein, is involved in various in vivo pathophysiological processes. This study aimed to explore the neuroprotective effects and mechanisms of a novel bioactive ANXA1 tripeptide (ANXA1sp) in SAE. Forty Sprague–Dawley rats were randomly divided into four groups (n = 10 each): control, SAE (intraperitoneal injection of lipopolysaccharide), vehicle (SAE + normal saline), and ANXA1sp (SAE + ANXA1sp) groups. Changes in serum inflammatory factors (interleukin‐6 [IL‐6], tumor necrosis factor‐α [TNF‐α]), hippocampal reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and adenosine triphosphate (ATP) levels were measured. The Morris water maze and Y maze tests were used to assess learning and memory capabilities in the rats. Further, changes in peroxisome proliferator–activated receptor‐gamma (PPAR‐γ) and apoptosis‐related protein expression were detected using western blot. The IL‐6, TNF‐α, and ROS levels were significantly increased in the SAE group compared with the levels in the control group. Intraperitoneal administration of ANXA1sp led to a significant decrease in the IL‐6, TNF‐α, and ROS levels (p < 0.05). Compared with the SAE group, the ANXA1sp group exhibited reduced escape latency on day 5, a significant increase in the number of platform crossings and the percent spontaneous alternation, and significantly higher hippocampal MMP and ATP levels (p < 0.05). Meanwhile, the expression level of PPAR‐γ protein in the ANXA1sp group was significantly increased compared with that in the other groups (p < 0.05). The expressions of apoptosis‐related proteins (nuclear factor‐kappa B [NF‐κB], Bax, and Caspase‐3) in the SAE and vehicle groups were significantly increased, with a noticeable decrease in Bcl‐2 expression, compared with that noted in the control group. Moreover, the expressions of NF‐κB, Bax, and Caspase‐3 were significantly decreased in the ANXA1sp group, and the expression of Bcl‐2 was markedly increased (p < 0.05). ANXA1sp can effectively reverse cognitive impairment in rats with SAE. The neuroprotective effect of ANXA1sp may be attributed to the activation of the PPAR‐γ pathway, resulting in reduced neuroinflammatory response and inhibition of apoptosis.

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ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus

Cited by 10 publications

References 93 publications

Stimulators of immunogenic cell death for cancer therapy: focusing on natural compounds

Stimulators of immunogenic cell death for cancer therapy: focusing on natural compounds

Special Issue “Physiology and Pathophysiology of the Placenta”

Neuroprotective effects of annexin A1 tripeptide in rats with sepsis‐associated encephalopathy

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