Annona muricata L. extracts decrease melanogenesis in B16F10 mouse melanoma cells

Abstract

Background: Annona muricata (A. muricata) L. (also known as graviola) contains various antioxidants that have beneficial effects on headaches, hypertension, coughs and asthma. A. muricata L. also has various other physiological effects, such as antispasmodic effects for the treatment of heart conditions, and sedative and nervine effects. In the present study, the effect of A. muricata L. extracts on melanogenesis was investigated and the ensuing inhibitory mechanisms were determined. Methods: The inhibitory effects of A. muricata L. extracts on melanogenesis were initially investigated by measuring melanin contents. Subsequently, the ensuing mechanisms were characterized by determining changes in the activity of tyrosinase, which is the rate-limiting step of melanogenesis. Finally, mRNA and protein expression levels of tyrosinase and the melanogenesis-associated transcription factor (MITF) were determined.

Phytochemical Profile and Anticancer Activity from Medicinal Plants Against Melanoma Skin Cancer: A Review

“…Moreover, tyrosinase mRNA and protein expression levels were regulated by A. muricata L extract. The MITF mRNA expression level decreased in the presence of A. muricata L extract (Joo et al, 2017). The mechanisn of Annona muricata L showed by…”

“…In addition, the active components of the leaves and seeds have a cytotoxic effect on cancer cells (Baskar et al 2007). The study by Joo et al (2017) found that a decrease in melanin content after treatment with A. muricata L. extract (concentration 60 μg/mL) showed a skin-whitening effect, and this change was the effect of a decrease in tyrosinase activity in melanoma cells. B16F10 mice.…”