Annona sp: Plants with Multiple Applications as Alternative Medicine - A Review

Barbalho, Sandra Maria; Goulart, Ricardo de Álvares; Farinazzi-Machado, Flávia Maria Vasques; Souza, Maricelma da Silva Soares de; Bueno, Patrícia Cincotto dos Santos; Guiguer, Élen Landgraf; Araújo, Adriano Cressoni; Groppo, Milton

doi:10.2174/157340712802762500

Cited by 25 publications

(22 citation statements)

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“…Despite the existence of records on antiproliferative efficacy of various Annonaceous species (such as A. muricata, A. squamosa or A. reticulata) (Barbalho et al, 2012), the cytotoxicity has not previously been recorded for A. montana. Acetogenins are regarded as being chiefly responsible for prominent anticancer effect of Annonaceous species (Smith et al, 2014).…”

Section: Discussionmentioning

confidence: 97%

Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

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Bortl

Huml

et al. 2016

Revista Brasileira de Farmacognosia

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Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 +/- 51.4 mu g TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 mu g/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 mu g TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 mu g/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 mu g TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 mu g/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases

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Section: Discussionmentioning

confidence: 97%

Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Tauchen

Bortl

Huml

et al. 2016

Revista Brasileira de Farmacognosia

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“…Annona species have been used as medicines by indigenous people for a wide range of disorders including parasitic infections, inflammation, diabetes, and cancer [3]. The phytochemical investigation of this plant genus has revealed the presence of acetogenins, alkaloids, essential oils, flavonoids, terpenoids, and other chemical classes [4,5]. Acetogenins (ACGs) are the major constituents of the Annona genre and examples were found to possess a variety of pharmacological properties including as antitumor, immunosuppressive, pesticidal, antiprotozoal, antimicrobial, antimalarial, anthelmintic, and antiviral agents, with some being commercially developed for the treatment of oral herpes and treating infestations of head lice, fleas, and ticks [5,6].…”

Section: Introductionmentioning

confidence: 99%

Anti-Infective and Anti-Cancer Properties of the Annona Species: Their Ethnomedicinal Uses, Alkaloid Diversity, and Pharmacological Activities

et al. 2019

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Annona species have been a valuable source of anti-infective and anticancer agents. However, only limited evaluations of their alkaloids have been carried out. This review collates and evaluates the biological data from extracts and purified isolates for their anti-infective and anti-cancer activities. An isoquinoline backbone is a major structural alkaloid moiety of the Annona genus, and more than 83 alkaloids have been isolated from this genus alone. Crude extracts of Annona genus are reported with moderate activities against Plasmodium falciparum showing larvicidal activities. However, no pure compounds from the Annona genus were tested against the parasite. The methanol extract of Annona muricata showed apparent antimicrobial activities. The isolated alkaloids from this genus including liriodenine, anonaine, asimilobine showed sensitivity against Staphylococcus epidermidis. Other alkaloids such as (+)-Xylopine and isocoreximine indicated significant anti-cancer activity against A549 and K-562 cell lines, respectively. This review revealed that the alkaloids from Annona genus are rich in structural diversity and pharmacological activities. Further exploration of this genus and their alkaloids has potential for developing novel anti-infective and anticancer drugs.

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“…La actividad antileishmania contra promastigotes de L. braziliensis fue significativa en los extractos etanólicos de A. mucosa (IC 50 =30,5 µg/mL), A. nitida (IC 50 =47,8 µg/mL) y A. montana (IC 50 =16,4 µg/mL); estos extractos presentan flavonoides, alcaloides y otros fenoles de acuerdo al tamizaje fitoquímico realizado en estudios previos (15,16) .…”

Section: Discussionunclassified

Actividad inhibitoria in vitro de extractos etanólicos de plantas del género Annona y Piper sobre promastigotes de Leishmania braziliensis

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2019

Rev. per. med. integr.

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Objetivo. Evaluar el efecto de extractos etanólicos de cinco especies del género Annona y cinco especies del género Piper frente a la línea clonal de referencia de promastigotes de Leishmania braziliensis. Materiales y métodos. Se evaluó el efecto de los extractos etanolicos de Annona hypoglauca, Annonamontana, mucosa, Annona nítida, Annona squamosa, Piper acutifolium¸ Piper aduncum, Piper callosum,Piper carpunya y Piper peltatum; sobre cepas de promastigotes de Leishmania braziliensis MHON/BR/79/M2904. El efecto leishmanicida in vitro se evaluó mediante el cálculo del IC50 por el método probit. Resultados. Las especies con mayor actividad fueron P. acutifolium (IC50=19,40 μg/mL) P. peltatum (IC50=26,6 μg/mL), P. callosum (IC50=21,7 μg/mL), A. mucosa (IC50=30,5 μg/mL) y A. montana (IC50=16,4 μg/mL). Conclusión. Los extractos etanólicos de P. acutifolium, P. peltatum, P. callosum, A. mucosa y A. montana, han mostrado una actividad leishmanicida in vitro. Sin embargo, estos efectos no son superiores a los exhibidos por Anfotericina B.

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Annona sp: Plants with Multiple Applications as Alternative Medicine - A Review

Cited by 25 publications

References 0 publications

Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Anti-Infective and Anti-Cancer Properties of the Annona Species: Their Ethnomedicinal Uses, Alkaloid Diversity, and Pharmacological Activities

Actividad inhibitoria in vitro de extractos etanólicos de plantas del género Annona y Piper sobre promastigotes de Leishmania braziliensis

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