Annoying Hiccups following Intra-Articular Corticosteroid Injection of Betamethasone Acetate/Betamethasone Sodium Phosphate at the Knee Joint

Abstract

Hiccups is a type of reflex that could happen secondary to different causes including drugs, especially systemic corticosteroids. Usually, high rather than regular doses of systemic steroids are incriminated, and this could explain the fact that very few cases of hiccups following regional corticosteroid treatment were reported. Here, we report the first case of hiccups in the English literature following intra-articular corticosteroid injection (IACI) at the knee joint and review all the previous reported cases of hiccups following regional corticosteroid treatment. Usually, this phenomenon of hiccups responds to regular antihiccups treatment; however, it is recommended not to repeat an IACI in a patient who had this adverse effect before due to an expected severe recurrent attack of hiccups afterwards.

Hoquet induit par les glucocorticoïdes

“…On pense que les stéroïdes stimulent le réflexe du hoquet à travers des récepteurs stéroïdiens [17,22]. Ils sont connus pour avoir un impact sur les neurotransmetteurs du tronc cérébral et des propriétés neuroexcitatrices [19,23].…”

“…Des cas particuliers de hoquets liés à des injections intraarticulaires de corticoïdes ont été rarement rapportés [10,22]. De même, les injections épidurales lombaires et thoraciques de stéroïdes peuvent induire un hoquet.…”

Modern Trends in Total Knee Arthroplasty

“…A currently widely used method of alleviating knee pain nonsurgically is through intra-articular injections, including corticosteroids and hyaluronic acid [19][20][21][22][23][24][25][26][27][28]. Corticosteroids have significant pain reducing effects on patients; however, there have not been any identified predictors of response to intra-articular corticosteroid injections [19,20].…”

“…Corticosteroids have significant pain reducing effects on patients; however, there have not been any identified predictors of response to intra-articular corticosteroid injections [19,20]. In a study by Habib et al, a hiccup reflex occurring following an intra-articular corticosteroid injection was reported, and the authors recommended avoiding corticosteroid injections if this phenomenon is known to happen in a patient [21]. A meta-analysis and systematic review focused on injection technique itself, determining whether the accuracy of intra-articular knee injections varied and if the accuracy and site of injection was connected to the efficacy of the treatment [22].…”

Use of prolonged corticosteroids and hyaluronic acid salts in treatment of gonarthrosis

“…Однако другие авторы не высказывают очевидных опасений в связи с их ис-пользованием. Исследованию сравнительной эф-фективности раздельного применения посвящено немало исследований [6,9,10,[12][13][14][15]17], в то время как оценка клинической результативности совмест-ного ВСВ этих препаратов и моновведения гиалуро-натов встречается лишь в единичных сообщениях [11].…”