This study investigates the human health risks of uranium, radium, radon, and other drinking water radionuclides and their mitigation strategies. It was implemented through literature review, field sampling, and analytical methods. Samples were taken from various sources, including groundwater, surface water, municipal supplies, and private wells. ICPI-MS and liquid scintillation counters were used for radiation measurements. Statistical analysis and risk assessment models were used to measure health risks and treatment effectiveness. Groundwater sources were the main sources of radionuclides, with private wells being the main sources. The elimination efficiencies of reverse osmosis were exceptional, reaching up to 99%. The elderly population (60+ years) were the most likely to have cancer, with the highest risks for bladder cancer, lung cancer, kidney cancer, and leukemia. The frequency of radionuclide contamination in drinking water sources varied, with the U.S. Environmental Protection Agency, Nigerian EPA, and Canada having the strictest schedules. The results emphasize the urgent need for monitoring programs, effective treatment technologies, and targeted risk management strategies to cope with radionuclide contamination. Government advice includes improving the regulatory system, developing advanced treatment methods, long-term epidemiological studies, public awareness, interdisciplinary collaboration, scientific exploration of alternative water sources, and prioritizing interventions for vulnerable populations.