Annual glycemic variations and risk of cancer among Chinese patients with type 2 diabetes mellitus: A population-based cohort study in Shanghai

Xu, Huilin; Zhang, Fen; Xu, Wanghong; Li, Jun; Zhu, Jingjing; Zhang, Minlu; Wu, Zhenyu; Qin, Guoyou

doi:10.1016/j.diabres.2020.108552

Cited by 2 publications

(4 citation statements)

References 31 publications

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“…Results slightly differed among previous studies due to different selection criteria and inclusion of covariates. Our research supported the positive association between FBG variability and all‐sites cancer among T2DM patients 19 . The findings on FBG variability were in accordance with those from previous research that observed a nonlinear association with cancer incidence grouped by gender.…”

Section: Discussionsupporting

confidence: 92%

“…Our research supported the positive association between FBG variability and all‐sites cancer among T2DM patients. 19 The findings on FBG variability were in accordance with those from previous research that observed a nonlinear association with cancer incidence grouped by gender. Furthermore, we added a new viewpoint that the observed nonlinear association remained even though we use different variability indicators regardless of gender.…”

Section: Discussionsupporting

confidence: 90%

“…The DMSP was launched as a basic public health service program from 2004 in Minhang District and covered over 1 million residents in Shanghai. 18 , 19 More detailed information can be found in previous literature. A total of 51 970 patients aged between 20 and 80 years were initially included in the study from 2004 to 2015.…”

Section: Methodsmentioning

confidence: 99%

“…In this retrospective cohort study, participants were drawn from the Diabetes Standardized Management Program (DSMP) in Shanghai's Minhang District, China, including more than 50 000 Chinese patients who had been given a T2DM diagnosis based on the World Health Organization diagnostic criteria from 1999. The DMSP was launched as a basic public health service program from 2004 in Minhang District and covered over 1 million residents in Shanghai 18,19. More detailed information canF I G U R E1 Flow chart for study participant filtration.…”

mentioning

confidence: 99%

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Long‐term fasting glucose variability and risk of cancer in patients with type 2 diabetes mellitus: A retrospective population‐based cohort study in Shanghai

Cui

Yang

et al. 2022

Journal of Diabetes

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Backgrounds Fasting blood glucose (FBG) variability may make an impact on adverse events in patients with diabetes mellitus. However, the association between long‐term changes in FBG and cancer remains unclear. We aimed to investigate this association in a large‐scale longitudinal study. Methods Data were collected from 46 761 patients with type 2 diabetes mellitus aged 20–80 years who participated in the Diabetes Standardized Management Program in Shanghai, China. We adopted four indicators, including standard deviation (SD), coefficient of variation (CV), variation independent of the mean (VIM), and average real variability (ARV) to describe FBG variability. Adjusted multivariable Cox regression analyses and restricted cubic splines were used to investigate the association between long‐term FBG variability and cancer risk. We also determined the interactive effect of FBG variability with hypertension and FBG‐mean with hypertension on cancer risk, respectively. Results In this study, we confirmed 2218 cancer cases (51.1% male) over a median follow‐up of 2.86 years. In the multivariable‐adjusted models, participants in the highest quartile of FBG variability had an increased risk of cancer compared with those in the lowest quartile. The nonlinear association was found when using FBG‐VIM, FBG‐ARV, and FBG‐SD in restricted cubic spline plots. There was a significant interaction effect of FBG variability with hypertension on cancer, whereas the effect of FBG‐mean with hypertension did not attain significance. Conclusions Our retrospective cohort study demonstrated a positive association between the long‐term changes in FBG and cancer risk in patients with type 2 diabetes mellitus. FBG variability may independently predict cancer incidence.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%