Annual outpatient hysteroscopy and endometrial sampling (OHES) in HNPCC/Lynch syndrome (LS)

Abstract

Our findings suggest that in LS, annual OHES is acceptable and has high diagnostic accuracy for EC/AEH screening. Larger international studies are needed for confirmation, given the relatively small numbers of LS women at individual centres. It reinforces the current recommendation that endometrial sampling is crucial when screening these women.

ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer

“…Findings from a prospective observational cohort study of women with LS opting for endometrial cancer screening and who underwent annual outpatient hysteroscopy and endometrial sampling (OHES) suggest that in women with LS, annual OHES is acceptable and has high diagnostic accuracy in screening for endometrial cancer and atypical endometrial hyperplasia (AEH) 29. However, larger international studies are needed for confirmation.…”

The role of peritoneal cytology at risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of familial ovarian/tubal cancer

“…The role of cytology obtained from peritoneal washings has received less attention, with even commentaries by some authoritative experts omitting to remark on this point. [1] As a result, practice varies among surgeons and institutions, with some published series reporting cytological findings at RRSO, [2][3][4] a number omitting to mention this, [5,6] and recently one suggesting it is not necessary. [7] This is an important issue for clinical practice which requires addressing.…”

Screening for gynecological cancers

“…Results of a more recent prospective observational cohort study of 41 LS women attending a tertiary high-risk familial gynaecological cancer clinic have been reported [164]. These data show that showed annual outpatient hysteroscopy and endometrial sampling (OHES) is acceptable to the women and has high diagnostic accuracy for endometrial cancer.…”