Annual report to the nation on the status of cancer, part I: National cancer statistics

Abstract

System. Trends in incidence and death rates for all cancers combined and for the leading cancer types by sex, racial/ethnic group, and age were estimated by joinpoint analysis and characterized by the average annual percent change during the most recent 5 years (2012-2016 for incidence and 2013-2017 for mortality). RESULTS: Overall, cancer incidence rates decreased 0.6% on average per year during 2012 through 2016, but trends differed by sex, racial/ ethnic group, and cancer type. Among males, cancer incidence rates were stable overall and among non-Hispanic white males but decreased in other racial/ethnic groups; rates increased for 5 of the 17 most common cancers, were stable for 7 cancers (including prostate), and decreased for 5 cancers (including lung and bronchus [lung] and colorectal). Among females, cancer incidence rates increased during 2012 to 2016 in all racial/ethnic groups, increasing on average 0.2% per year; rates increased for 8 of the 18 most common cancers (including breast), were stable for 6 cancers (including colorectal), and decreased for 4 cancers (including lung). Overall, cancer death rates decreased 1.5% on average per year during 2013 to 2017, decreasing 1.8% per year among males and 1.4% per year among females. During 2013 to 2017, cancer death rates decreased for all cancers combined among both males and females in each racial/ethnic group, for 11 of the 19 most common cancers among males (including lung and colorectal), and for 14 of the 20 most common cancers among females (including lung, colorectal, and breast). The largest declines in death rates were observed for melanoma of the skin (decreasing 6.1% per year among males and 6.3% among females) and lung (decreasing 4.8% per year among males and 3.7% among females). Among children younger than 15 years, cancer incidence rates increased an average of 0.8% per year during 2012 to 2016, and cancer death rates decreased an average of 1.4% per year during 2013 to 2017. Among adolescents and young adults aged 15 to 39 years, cancer incidence rates increased an average of 0.9% per year during 2012 to 2016, and cancer death rates decreased an average of 1.0% per year during 2013 to 2017. CONCLUSIONS: Although overall cancer death rates continue to decline, incidence rates are leveling off among males and are increasing slightly among females. These trends reflect population changes in cancer risk factors, screening test use, diagnostic practices, and treatment advances. Many cancers can be prevented or treated effectively if they are found early. Population-based cancer incidence and mortality data can be used to inform efforts to decrease the cancer burden in the United States and regularly monitor progress toward goals. Cancer 2020;126:2225-2249.

Emerging immunotherapies in multiple myeloma

“…4 5 In the US, the age standardized incidence rate was higher than the global rate at 7.1 per 100 000 people in 2016, 6 and incident rates have gradually increased, which is consistent with the global trend. 7 The prevalence of this cancer has also increased, given that the median overall survival for patients has doubled in the past decade. 8 9 for sustained disease control with an immune mediated graft versus myeloma effect by establishing donor chimerism.…”

Proteomic Profiling of Colon Cancer Tissues: Discovery of New Candidate Biomarkers

“…Among the differentially expressed proteins, TAGL was chosen for further validation, since it is among the top ten modulated proteins, and because four different protein species, collectively down-regulated in colon cancer tissues, were identified in our proteomic investigation. Figure 4A shows gel windows of 2D-gels of CCT and NAT, where the four TAGL protein species are indicated by numbers (1)(2)(3)(4), starting from the most acidic one. Two TAGL protein species display a molecular weight (MW) of about 23 kDa, representing the closest expected value of the native protein, while the others display a lower MW, (ca.…”

“…Colorectal cancer (CRC) is an aggressive type of tumor and a leading cause of cancer death worldwide [1]. CRC is considered a multifactorial disease: an important role is attributed to the impact of environmental factors on a genetically prone background [2].…”

Solar Ultraviolet Exposure in Individuals Who Perform Outdoor Sport Activities

“…According to 2012 estimations, the number of patients diagnosed annually with non-melanoma skin cancer (NMSC) approaches 3.3 million, representing a 50% increase from 2006 [2,3]. The 2020 Annual Report to the Nation on the Status of Cancer reveals an annual incidence of melanoma of 28.5 per 100,000 persons for men and 17.6 per 100,000 for women, which translates to a respective 5-year average annual percent change of 2.2% and 1.9% [4]. The WHO's International Agency for Research on Cancer reports an age-standardized incidence rate (ASR) of all skin cancers at 68.1 per 100,000 persons in the USA.…”