Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Cagna, David R.; Donovan, Terence E.; McKee, James R.; Eichmiller, Frederick C.; Metz, James E.; Albouy, Jean‐Pierre; Marzola, Riccardo; Murphy, Kevin R.; Troeltzsch, Matthias

doi:10.1016/j.prosdent.2019.05.010

Cited by 7 publications

(5 citation statements)

References 379 publications

(347 reference statements)

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“…The human oral microbiome (HOM) is the second largest and complex microbial community after that of the gut in the human body ( Wade, 2013 ; Caselli et al, 2020a ). HOM dysbiosis is often associated with periodontal inflammation and has been reportedly associated with several local and systemic disease conditions ( Baghbani et al, 2020 ; Caselli et al, 2020a ), including those sustained by viral infections ( Cagna et al, 2019 ; Baghbani et al, 2020 ). Indeed, the role of HOM in the establishment of the infection of many viruses entering the body via the oropharynx has been reportedly recognized ( Baghbani et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients: A Cross-Sectional Study

et al. 2021

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The human oral microbiome (HOM) is the second largest microbial community after the gut and can impact the onset and progression of several localized and systemic diseases, including those of viral origin, especially for viruses entering the body via the oropharynx. However, this important aspect has not been clarified for the new pandemic human coronavirus SARS-CoV-2, causing COVID-19 disease, despite it being one of the many respiratory viruses having the oropharynx as the primary site of replication. In particular, no data are available about the non-bacterial components of the HOM (fungi, viruses), which instead has been shown to be crucial for other diseases. Consistent with this, this study aimed to define the HOM in COVID-19 patients, to evidence any association between its profile and the clinical disease. Seventy-five oral rinse samples were analyzed by Whole Genome Sequencing (WGS) to simultaneously identify oral bacteria, fungi, and viruses. To correlate the HOM profile with local virus replication, the SARS-CoV-2 amount in the oral cavity was quantified by digital droplet PCR. Moreover, local inflammation and secretory immune response were also assessed, respectively by measuring the local release of pro-inflammatory cytokines (L-6, IL-17, TNFα, and GM-CSF) and the production of secretory immunoglobulins A (sIgA). The results showed the presence of oral dysbiosis in COVID-19 patients compared to matched controls, with significantly decreased alpha-diversity value and lower species richness in COVID-19 subjects. Notably, oral dysbiosis correlated with symptom severity (p = 0.006), and increased local inflammation (p < 0.01). In parallel, a decreased mucosal sIgA response was observed in more severely symptomatic patients (p = 0.02), suggesting that local immune response is important in the early control of virus infection and that its correct development is influenced by the HOM profile. In conclusion, the data presented here suggest that the HOM profile may be important in defining the individual susceptibility to SARS-CoV-2 infection, facilitating inflammation and virus replication, or rather, inducing a protective IgA response. Although it is not possible to determine whether the alteration in the microbial community is the cause or effect of the SARS-CoV-2 replication, these parameters may be considered as markers for personalized therapy and vaccine development.

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Section: Introductionmentioning

confidence: 99%

Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients: A Cross-Sectional Study

et al. 2021

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“…Both adhesive and composite resins are also susceptible to polymerisation shrinkage upon light-curing which leads to the development of gaps at the tooth-restorative interface, thus creating a pathway for bacterial ingress, colonisation and induction of secondary caries. Recurrent caries is the most common reason for the replacement of dental restorations [50]. The replacement or repair of restorations may lead to compromising of remaining tooth structure and could eventually result in the loss of a tooth [51].…”

Section: Dental Adhesives and Direct Restorative Materialsmentioning

confidence: 99%

Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications

et al. 2021

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The risk of secondary bacterial infections resulting from dental procedures has driven the design of antimicrobial and antifouling dental materials to curb pathogenic microbial growth, biofilm formation and subsequent oral and dental diseases. Studies have investigated approaches based primarily on contact-killing or release-killing materials. These materials are designed for addition into dental resins, adhesives and fillings or as immobilized coatings on tooth surfaces, titanium implants and dental prosthetics. This review discusses the recent developments in the different classes of biomaterials for antimicrobial and antifouling dental applications: polymeric drug-releasing materials, polymeric and metallic nanoparticles, polymeric biocides and antimicrobial peptides. With modifications to improve cytotoxicity and mechanical properties, contact-killing and anti-adhesion materials show potential for incorporation into dental materials for long-term clinical use as opposed to short-lived antimicrobial release-based coatings. However, extended durations of biocompatibility testing, and adjustment of essential biomaterial features to enhance material longevity in the oral cavity require further investigations to confirm suitability and safety of these materials in the clinical setting. The continuous exposure of dental restorative and regenerative materials to pathogenic microbes necessitates the implementation of antimicrobial and antifouling materials to either replace antibiotics or improve its rational use, especially in the day and age of the ever-increasing problem of antimicrobial resistance.

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“…Telescopic systems are employed to retain removable dentures that are usually indicated for patients with few remaining teeth [7], [8], [9]. It is considered an ideal treatment approach when a fixed treatment option cannot be utilized due to compromised or unfavorable general health conditions [10], [11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Using Different Primary Crown Materials on the Retention of CAD/CAM Telescopic Partial Dentures

Abdallah

Elsaeid

Thabet

2023

Open Access Maced J Med Sci

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AIM: This study compared the effect of using different primary crown materials (zirconia and cobalt-chromium) on the retention of telescopic retained removable partial dentures. MATERIALS AND METHODS: A maxillary Kennedy class I stone model was prepared and scanned. The virtual cast was adjusted to create four abutments at the positions of the canines and the first premolars. Primary crowns were designed and then milled. In Group I, seven primary crowns were milled out of zirconia, and in Group II, seven primary crowns were milled from cobalt-chromium blanks. Cobalt-chromium telescopic partial dentures were milled. The universal testing machine was utilized to apply vertically dislodging static forces. Initial retention values were recorded. Then, the chewing simulator (CS) was used to apply dynamic cyclic loading to each partial denture. And after, 50,000 cycles and 270 attempts of insertion and removal final retention values were recorded. The data were collected and statistically analyzed. RESULTS: A significant decrease in retention in both groups after simulation of 3 months of partial denture function was recorded. It was found that after simulation of 3 months of function Group I (zirconia) recorded a statistically significant higher mean value; (1.935 ± 0.268 N) than Group II; (0.583 ± 0.018 N) as indicated by student t-test (p ≤ 0.0001 < 0.05). CONCLUSION: Zirconia primary crowns attain higher retention values than cobalt-chromium with cobalt-chromium telescopic partial dentures after simulation of 3 months of function.

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Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Cited by 7 publications

References 379 publications

Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients: A Cross-Sectional Study

Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients: A Cross-Sectional Study

Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications

Effect of Using Different Primary Crown Materials on the Retention of CAD/CAM Telescopic Partial Dentures

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