Annular erythema: A possible association with primary Sjögren's syndrome

Teramoto, Noriko; Katayama, Ichiro; Arai, Harue; Eto, Hikaru; Kamimura, Kimio; Uetsuka, Mari; Kondô, Shigeo; Nishioka, Kiyoshi; Nishiyama, Shigeo

doi:10.1016/s0190-9622(89)70070-0

Cited by 102 publications

(60 citation statements)

References 15 publications

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“…As previously reported [1], AESjS mimics Sweet dis ease clinically and shows distinct histopathological features resembling Darier's annular erythema which can be distin guished from SCLE. This type of erythema predominantly occurs in Asian people with positive anti-SS-A and/or -SS-B antibodies [1][2][3][4][5].…”

Section: Discussionsupporting

confidence: 71%

“…It has been reported in the recent literature that patients with Sjögren syndrome (SjS) frequently develop annular erythematous lesions, which is clearly distinct from sub acute cutaneous lupus erythematosus (SCLE) on the basis of clinical, histopathological and immunological analysis [1][2][3][4][5]. Most of the cases have been reported from the Asian area, especially from Japan.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Immunological Analysis of Annular Erythema Associated with Sjögren Syndrome

Katayama

Yamamoto²,

Otoyama³

et al. 1994

Dermatology

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Clinical and immunopathological analysis was performed on 24 cases of Sjögren syndrome with annular erythema (AESjS). AESjS predominantly appears on the cheek of the face where skin temperature is relatively low in comparison with other sites. VCAM-1 and ICAM-1 were strongly expressed on endothelial cells of AESjS, while epidermal expression of ICAM-1 was focal and weak. VCAM-1 mRNA expression was also much more intense compared to systemic lupus erythematosus. The lymphocyte response to staphylococcal enterotoxin B was higher in AESjS than that of controls, and cells positive for T cell receptor Vβ6,9,12 were expanded after the culture. Superantigen-driven endothelial-cell-dependent T cell infiltration to the skin plays a crucial role in AESjS.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Clinical and Immunological Analysis of Annular Erythema Associated with Sjögren Syndrome

Katayama

Yamamoto²,

Otoyama³

et al. 1994

Dermatology

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“…Histologically, there is no significant change in the epidermis, but a remarkable lymphocytic infiltration around the blood vessels and appendages is observed throughout the dermis. A lupus band test is negative in most cases [1,4]. The annular erythema can be distin guished clinically as well as histopathologically from the annular-polycyclic lesions of subacute cutaneous lupus ery thematosus which occur frequently in anti-Ro/SS-A-positive patients of European origin [5,6].…”

mentioning

confidence: 99%

Clinical, Serological and Immunogenetic Features of Japanese Anti-Ro/SS-A-Positive Patients with Annular Erythema

Miyagawa

1994

Dermatology

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Sixteen anti-Ro/SS-A-positive patients with recurrent annular erythema, which has recently been recognized as a unique cutaneous manifestation of Sjögren’s syndrome, were studied. Eight of the 16 patients met the American Rheumatism Association criteria for systemic lupus erythematosus. Fifteen patients had anti-La/SS-B antibodies. Antibodies against U1RNP were detected in 2 patients with systemic lupus erythematosus, 1 with anti-Sm antibodies. Patterns of autoimmune response to Ro/SS-A antigens were variable by immunoblot analysis. HLA typing by the standard complement-dependent microcytotoxicity assay revealed that all the 16 patients were positive for HLA-DRw52 antigens but negative for either HLA-B8 or HLA-DR3 which is reportedly associated with the autoimmune response to Ro/SS-A antigens in white and black patients.

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“…Later, annular erythema resembling the subacute lesion was frequently observed in Asian patients with SS, and anti-SS-A (Ro) antibodies have been detected in 50% to 60% of serum samples from these patients, the percentage of which is similar to that in subacute cutaneous LE. [9][10][11][33][34][35] There has been a close linkage between annular ery- thema and anti-SS-A (Ro) antibodies, but we did not find any association of annular lesions with JS-1 antibody production ( Figure 3). Therefore, we speculated that a diseasespecific expression of ␣-fodrin could be observed at the eccrine sweat duct and may play a crucial role during the development of SS-relevant skin lesions because it has been reported 13 that 120-kd ␣-fodrin is intensely expressed on the epithelial duct of inflamed salivary glands.…”

Section: Commentmentioning

confidence: 92%

“…7 Provost et al 8 described 10 patients with SS and LE who were positive for anti-SS-A (Ro) and pointed out a close clinical and pathological relationship. In addition, several authors [9][10][11] reported that annular erythema develops in Asian patients with SS and LE, but attempts to identify autoantibodies specific for this skin lesion have been unsuccessful. 12 There is clearly a need for a new laboratory test to discriminate SS from LE.…”

mentioning

confidence: 99%