Annular pustular psoriasis

Rogel-Vence, María; González‐Ruiz, Lucía; Sánchez-Mateos, J.L. Santiago

doi:10.1016/j.medcle.2019.07.016

Cited by 1 publication

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“…Usual sites of involvement are flexural areas of the trunk and proximal extremities, buttocks and abdomen [ 41 ]. Formerly included within the spectrum of GPP, it is now considered a separate entity [ 42 ], with a preference for younger age groups and an overall benign, sub-acute and self-resolving course.…”

Section: Nosological Aspectsmentioning

confidence: 99%

Pustular Psoriasis: From Pathophysiology to Treatment

Genovese

Moltrasio

Cassano³

et al. 2021

Biomedicines

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Pustular psoriasis (PP) is a clinicopathological entity encompassing different variants, i.e., acute generalized PP (GPP), PP of pregnancy (impetigo herpetiformis), annular (and circinate) PP, infantile/juvenile PP, palmoplantar PP/palmoplantar pustulosis, and acrodermatitis continua of Hallopeau (ACH), which have in common an eruption of superficial sterile pustules on an erythematous base. Unlike psoriasis vulgaris, in which a key role is played by the adaptive immune system and interleukin (IL)-17/IL-23 axis, PP seems to be characterized by an intense inflammatory response resulting from innate immunity hyperactivation, with prominent involvement of the IL-36 axis. Some nosological aspects of PP are still controversial and debated. Moreover, owing to the rarity and heterogeneity of PP forms, data on prognosis and therapeutic management are limited. Recent progresses in the identification of genetic mutations and immunological mechanisms have promoted a better understanding of PP pathogenesis and might have important consequences on diagnostic refinement and treatment. In this narrative review, current findings in the pathogenesis, classification, clinical features, and therapeutic management of PP are briefly discussed.

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Section: Nosological Aspectsmentioning

confidence: 99%