Annurca apple-rich diet restores long-term potentiation and induces behavioral modifications in aged rats

Viggiano, Alessandro; Viggiano, Andrea; Monda, Marcellino; Turco, Imma; Incarnato, Lucia; Vinno, Vincenza; Viggiano, Emanuela; Baccari, Maria Ena; Luca, B. De

doi:10.1016/j.expneurol.2006.01.001

Cited by 49 publications

(26 citation statements)

References 59 publications

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“…Later, it was demonstrated that dietary intervention with apple juice concentrate was useful to augment remedial approach for age-related neurodegeneration as evident from alleviation of increased amyloid-β (Aβ) levels in normal adult mice, potentiated by apolipoprotein E deficiency (Chan and Shea 2009). Diet supplemented with fresh apples (annurca variety) showed a significant decrease in the anxiety level and improved ability to sustain long-term potentiating in aged rats (Viggiano et al 2006). Reactive oxygen species (ROS) not only plays an important role in cardiometabolic disorders, but also responsible for development of gastric adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Apple phenolics as nutraceuticals: assessment, analysis and application

Rana

Bhushan

2015

J Food Sci Technol

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Humankind is presently engulfed by convenience quench, modern life style and urbanized diet system leading to progression in array of health disorders. The past decade confronted cardiometabolic disorder (21.8 %), lower respiratory and chronic obstructive lung disease (12.5 %) as the major causes of death world over. In anticipation, scientific communities' have demonstrated the role of healthy diets, especially those rich in fruits and vegetables, for management of such health related issues. These horticultural crops are considered as a good source of polyphenols such as dihydrochalcones, flavanols, flavonols, anthocyanins and phenolic acids. The present article reviews the efforts made to assess the potential of apple phenolic compounds present in fresh fruits, leaves, bark and pomace as dietary polyphenols. Considering the positive impact of such phytochemicals on human health, various nutraceuticals, dietary supplements and phenolic-rich food products are presently available on market shelves. On analytical front, improved instrumentation based on liquid chromatography (HPLC, UPLC, LC/MS/ MS) have made the assessment of phenolics more rapid and reliable. Thus, owing to the emergent interest in natural compounds, it is pertinent to discuss the latest significant research findings on therapeutic aspects along with probable metabolic mechanisms of dietary polyphenols found in apples and their implications on human health.

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Section: Introductionmentioning

confidence: 99%

Apple phenolics as nutraceuticals: assessment, analysis and application

Rana

Bhushan

2015

J Food Sci Technol

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“…The present experiment demonstrated a modification of vegetative modulation in HRT-treated women with an increase of the sympathetic component [35][36][37][38], which is an important factor in maintaining the highest REE in women in HRT compared to women in menopause [39][40][41].…”

Section: Discussionmentioning

confidence: 86%

Modifications of Activity of Autonomic Nervous System, and Resting Energy Expenditure in Women Using Hormone-Replacement Therapy

Monda¹,

Valenzano²

2016

Biol Med (Aligarh)

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Menopause is a significant period characterized by physiological change. Hormonal changes are largely related to estrogen depletion and subsequent cessation of ovarian function. This study analyzed vegetative modulation, expressed as heart rate variability (HRV) power spectral analysis, resting energy expenditure, and body composition in women in post-menopause with and without hormone-replacement therapy (HRT). 87 Sedentary women were enrolled, 41 (age: 53-54) women with BMI of 21.6 ± 2.6 kg/m 2 were on HRT and 46 (age: 52-63) with BMI of 22.4 ± 1.8 kg/m 2 were not. This experiment marks aspects regarding the relationship between the autonomic nervous system and body weight in HRT and menopause.

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“…Although we cannot conclude much from these experiments with regards to the endogenous orexin system and its role, these experiments demonstrate that an icv administration of orexin A causes an increase in temperature of IBAT, that is strongest effector of unrelated-shivering thermogenesis in the rat [48][49][50], showing that the increase in heat production is also caused by a stimulation of nonshivering thermogenesis [48,[51][52][53]. The sympathetic nervous system controls the IBAT activity and factors, which affect thermogenesis, exert an action centrally to induce modification of the sympathetic discharge to IBAT [54, 45,55].…”

Section: Discussionmentioning

confidence: 91%

Neuroleptic Drugs Affect Sympathetic and Thermogenic Reactions to Orexin A

S¹

2014

J Psychiatry

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This review of our literature describes the effects of many neuroleptic drugs on the sympathetic and hyperthermic reactions due to orexin A, a neuropeptide affecting body temperature and food intake by an increase in sympathetic activity. Haloperidol reduces, while clozapine and olanzapine block the hyperthermia induced by orexin A. Risperidone enhances the elevation of body temperature due to orexin A. Quetiapine delays these hyperthermic effects. The implications on human therapeutic strategies are discussed, including the involvement of orexinergic pathway in the induction of obesity, induced by these neuroleptic substances. We summarize our published data in a unique report so to emphasize the influences of these neuroleptic drugs on the control of body temperature, exerted by orexinergic system. This large vision could be also useful to address therapeutic choices.Patients with serious mental illness are at higher risk of developing metabolic abnormalities (e.g., weight gain, increased blood pressure, and glucose or lipid levels) in comparison to general population. Since the risk increases following initiation of narcoleptic therapy, it must assess carefully risks and benefits when choosing a particular antipsychotic drug.

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Annurca apple-rich diet restores long-term potentiation and induces behavioral modifications in aged rats

Cited by 49 publications

References 59 publications

Apple phenolics as nutraceuticals: assessment, analysis and application

Apple phenolics as nutraceuticals: assessment, analysis and application

Modifications of Activity of Autonomic Nervous System, and Resting Energy Expenditure in Women Using Hormone-Replacement Therapy

Neuroleptic Drugs Affect Sympathetic and Thermogenic Reactions to Orexin A

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