Anodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex enhances emotion recognition in depressed patients and controls

Brennan, S.; McLoughlin, Declan M.; O’Connell, Redmond G; Bogue, John; O’Connor, Stephanie; McHugh, Caroline; Glennon, Mark

doi:10.1080/13803395.2016.1230595

Cited by 40 publications

(31 citation statements)

References 56 publications

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“…Also, the comparison of these 2 treatments showed that the effectiveness of tDCS on depression and pharmacotherapy on worry was more and had equal effect on treatment of anxiety, and there were not significant differences. The current results were consistent with previous researches that showed the effectiveness of tDCS on worry (15), anxiety (25), and depression (26 (27) showed that tDCS was effective in treatment of depressive symptoms. The studies of Kar and Sarkar (28) showed that the use of brain electrical stimulation was effective in treatment of anxiety.…”

Section: Discussionsupporting

confidence: 82%

Effectiveness of Transcranial Direct Current Stimulation on Worry, Anxiety, and Depression in Generalized Anxiety Disorder: A Randomized, Single-Blind Pharmacotherapy and Sham-Controlled Clinical Trial

Movahed

Goradel

Pouresmali

et al. 2018

Iran J Psychiatry Behav Sci

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Background: Due to low adherence to treatment and side effects of pharmacotherapy, using new brain stimulation, such as transcranial direct current stimulation in patients with anxiety disorders are available. Objectives: The present research was performed to evaluate the efficacy of transcranial direct current stimulation and compare tDCS with pharmacotherapy on reduction of worry, depression, and anxiety in a group of Iranian patients with generalized anxiety disorder (GAD). Methods: This study was a quasi-experimental research. A total of 18 patients (46% females and 64% males) with GAD were randomly assigned either to tDCS, pharmacotherapy or sham conditions. Stimulation was delivered over the contralateral deltoid at 2 m/A during 20 minutes in 10 sessions of 4 weeks. Symptoms were assessed by a 7-item GAD scale, HARS, HDRS, and PSWQ in pre-test, post-test and follow up assessment (2 months later). Analysis of variance with repeated measure was used to analyze the data. Results:The results showed that both tDCS and pharmacotherapy were effective in reducing worry symptoms, also the pharmacotherapy group compared with the tDCS group and sham condition was more effective in treating of worry. Anxiety symptoms were reduced by both tDCS and pharmacotherapy and the difference between the 2 methods was not significant. Finally, the effectiveness of tDCS therapy on reducing depressive symptoms was more significant than pharmacotherapy. Conclusions:The tDCS is a promising treatment for generalized anxiety disorder, especially in depressive and worry symptoms.

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Section: Discussionsupporting

confidence: 82%

Effectiveness of Transcranial Direct Current Stimulation on Worry, Anxiety, and Depression in Generalized Anxiety Disorder: A Randomized, Single-Blind Pharmacotherapy and Sham-Controlled Clinical Trial

Movahed

Goradel

Pouresmali

et al. 2018

Iran J Psychiatry Behav Sci

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“…The valence hypothesis proposes that affective processing exhibits hemispheric lateralization, with the right hemisphere specializing in negative emotion processing and the left hemisphere specializing in positive emotion processing (Prete et al, 2015 ). This hypothesis has been supported by neuroimaging studies (Grimm et al, 2008 ), and several previous studies have shown that the DLPFC influences emotional stimulus categorization, emotional evaluation, emotional memory, and emotional regulation (Brennan et al, 2017 ; Zilverstand et al, 2017 ). Thus, the DLPFC is thought to play a leading role in emotional control.…”

Section: Repetitive Transcranial Magnetic Stimulation (Rtms)mentioning

confidence: 72%

“…A number of studies have confirmed the role of tDCS in antidepressant treatment (Vigod et al, 2014 ; Al-Kaysi et al, 2017 ; Brennan et al, 2017 ). At present, the left and right DLPFC are typically used as anode and cathode stimulation sites for the majority of tDCS treatment methods, which can increase the excitability of the left DLPFC and inhibit the excitability of the right DLPFC to alleviate depressive symptoms (Meron et al, 2015 ).…”

Section: Transcranial Direct Current Stimulation (Tdcs)mentioning

confidence: 93%

Recent Advances in Non-invasive Brain Stimulation for Major Depressive Disorder

Shui

Sheng

et al. 2017

Front. Hum. Neurosci.

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Non-invasive brain stimulation (NBS) is a promising treatment for major depressive disorder (MDD), which is an affective processing disorder involving abnormal emotional processing. Many studies have shown that repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) over the prefrontal cortex can play a regulatory role in affective processing. Although the clinical efficacy of NBS in MDD has been demonstrated clinically, the precise mechanism of action remains unclear. Therefore, this review article summarizes the current status of NBS methods, including rTMS and tDCS, in the treatment of MDD. The article explores possible correlations between depressive symptoms and affective processing, highlighting the relevant affective processing mechanisms. Our review provides a reference for the safety and efficacy of NBS methods in the clinical treatment of MDD.

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“…Anodal stimulation over the primary motor cortex (M1) was delivered by a battery-driven constant-current stimulator (TCT Research Ltd tDCS Stimulator, TST Kowloon, Hong Kong) (Brennan et al, 2017;Wexler, 2015) with conductive rubber electrodes that were placed between two saline-soaked sponges. The anode electrode was placed over C3 (representing M1) according to the 10-20 EEG international system for electrode placement (Herwig, Satrapi, & Schonfeldt-Lecuona, 2003;Klem, Lüders, Jasper, & Elger, 1999).…”

Section: Procedures Tdcsmentioning

confidence: 99%

Poststimulation time interval-dependent effects of motor cortex anodal tDCS on reaction-time task performance

Molero‐Chamizo

Bailén

Béjar

et al. 2018

Cogn Affect Behav Neurosci

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Anodal transcranial direct current stimulation (tDCS) induces long-term potentiation-like plasticity, which is associated with long-lasting effects on different cognitive, emotional, and motor performances. Specifically, tDCS applied over the motor cortex is considered to improve reaction time in simple and complex tasks. The timing of tDCS relative to task performance could determine the efficacy of tDCS to modulate performance. The aim of this study was to compare the effects of a single session of anodal tDCS (1.5 mA, for 15 min) applied over the left primary motor cortex (M1) versus sham stimulation on performance of a go/no-go simple reaction-time task carried out at three different time points after tDCS-namely, 0, 30, or 60 min after stimulation. Performance zero min after anodal tDCS was improved during the whole course of the task. Performance 30 min after anodal tDCS was improved only in the last block of the reaction-time task. Performance 60 min after anodal tDCS was not significantly different throughout the entire task. These findings suggest that the motor cortex excitability changes induced by tDCS can improve motor responses, and these effects critically depend on the time interval between stimulation and task performance.

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Anodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex enhances emotion recognition in depressed patients and controls

Cited by 40 publications

References 56 publications

Effectiveness of Transcranial Direct Current Stimulation on Worry, Anxiety, and Depression in Generalized Anxiety Disorder: A Randomized, Single-Blind Pharmacotherapy and Sham-Controlled Clinical Trial

Effectiveness of Transcranial Direct Current Stimulation on Worry, Anxiety, and Depression in Generalized Anxiety Disorder: A Randomized, Single-Blind Pharmacotherapy and Sham-Controlled Clinical Trial

Recent Advances in Non-invasive Brain Stimulation for Major Depressive Disorder

Poststimulation time interval-dependent effects of motor cortex anodal tDCS on reaction-time task performance

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