Anodic oxidation of thioureido derivatives of biogenic amines at a glassy carbon electrode in an aqueous medium

Lomba, José Ramón González; Gil, Eduardo Pinilla; Moreno, P. C.; Carra, Rosa Maria; Misiego, A. Sánchez

doi:10.1016/0022-0728(96)04550-0

Cited by 4 publications

(1 citation statement)

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“…Also, the electrochemical oxidation of CP at polytyramine film doped with ruthenium (II) complex, devoted with kinetic and thermodynamic studies have been described 19 . On the other hand, the anodic oxidation at a glassy carbon electrode 20 , the electrocatalytic oxidation at multi-wall carbon nanotube modified glassy carbon electrode 21 and the adsorptive stripping voltammetric determination at carboxylated multi-walled carbon nanotube-modified electrode 22 have been described for PE.…”

Section: Introductionmentioning

confidence: 99%

CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS

Pérez-Ortiz

Pizarro

Álvarez‐Lueje

2019

J. Chil. Chem. Soc.

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A multi-walled carbon nanotube (MWCNT)-ionic liquid (IL) film-modified glassy carbon electrode (GCE) was constructed for the determination of pseudoephedrine (PE) and chlorpheniramine (CP) by differential pulse voltammetry (DPV). The MWCNT-IL film has shown an obvious electrocatalytic activity towards oxidation of PE and CP, since it increases the electroactive area, facilitates the electron transfer and significantly enhances the oxidation peak current of both. Also a synergistic effect between MWCNT and IL was detected; it improves the conductivity, resulting in a better response, thus the modified electrode presented higher sensitivity. Under the optimum conditions, the oxidation peak currents were linearly proportional to the concentration in the range from 40.3 to 161.3 µg/mL for PE and from 0.39 µg/mL to 27.4 µg/mL for CP. Detection limits were 32.4 µg/mL with 180 s accumulation for PE and 0.11 µg/mL with 240 s accumulation for CP. Finally, the proposed sensitive and simple electrochemical method was successfully applied to PE and CP determination in a pharmaceutical formulation, and recoveries were acceptable.

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Section: Introductionmentioning

confidence: 99%

CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS

Pérez-Ortiz

Pizarro

Álvarez‐Lueje

2019

J. Chil. Chem. Soc.

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Determination of Aliphatic Amines by High Performance Liquid Chromatography with Amperometric Detection after Derivatization with Phenylisothiocyanate

2000

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Liquid chromatography with amperometric oxidative detection is proposed as a sensitive method for the determination of aliphatic amines previously converted in thioureido derivatives by reaction with phenylisothiocyanate (PIT). The phenylthioureas of four model amines, methylamine (MA), propylamine (PA), n-butylamine (BA) and isobutylamine (IBA) have been synthesized and isolated. Their electrochemical behavior on a glassy carbon electrode has been explored by cyclic voltammetry. The thioureido derivatives can be oxidized through two one-electron steps at acidic pH values, presumably involving the intermediacy of proton transfers. A mechanistic pathway is also proposed on the basis of experimental data. Liquid chromatographic parameters as mobile phase composition and¯ow rate, temperature and working electrode potential have been optimized. The method permits the simultaneous determination of the phenylthioureas of the selected amines with detection limits in the lower mgL 71 range.

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Indirect determination of ephedrine in urine by differential pulse polarography

et al. 1997

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The nitrosation of ephedrine and the electrochemical reduction of N-nitrosoephedrine were investigated by differential pulse polarography and have been optimized in order to attain the optimum analytical signal. Reduction of the N-nitrosoephedrine was carried out in one irreversible, diffusioncontrolled step using potassium chloride-hydrochloric acid. In 0.1 M hydrochloric acid the N-nitrosoephedrine shows a well-defined reduction peak at -0.77V (vs. Ag/AgCl/ 3 M KC1). An indirect differential-pulse polarographic method is described for the determination of ephedrine at levels higher than 2.5 pg per mL of urine. An extraction procedure with Cis cartridge and a fast and easy nitrosation reaction with sodium nitrite in 0.2M phthalate potassium hydrogen is also described. Determination of 5 pg/mL of N-nitrosoephedrine in urine samples of 4 mL was possible using the standard addition method, with a relative error of -4.0 % and relative standard deviations no higher than 2. I %.

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Anodic oxidation of thioureido derivatives of biogenic amines at a glassy carbon electrode in an aqueous medium

Cited by 4 publications

References 10 publications

CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS

CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS

Determination of Aliphatic Amines by High Performance Liquid Chromatography with Amperometric Detection after Derivatization with Phenylisothiocyanate

Indirect determination of ephedrine in urine by differential pulse polarography

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Anodic oxidation of thioureido derivatives of biogenic amines at a glassy carbon electrode in an aqueous medium

Cited by 4 publications

References 10 publications

CARBON NANOTUBES&#8211;IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS

CARBON NANOTUBES&#8211;IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS

Determination of Aliphatic Amines by High Performance Liquid Chromatography with Amperometric Detection after Derivatization with Phenylisothiocyanate

Indirect determination of ephedrine in urine by differential pulse polarography

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Product

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CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS

CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS