Anodic Voltammetric Determination of an Atypical Antipsychotic Drug Amisulphide in Pharmaceutical Dosage Forms Using Electrochemical fsDNA Biosensor

Çeşme, Mustafa; Polat, Duygu; Şenel, Pelin; Gölcü, Ayşegül

doi:10.1134/s1023193519030042

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…The slope of the linear plot between log I p and log ʋ was calculated to be 0.54 for peak 1 and 0.49 for peak 2, a result that is close to the theoretical value of 0.5 predicted by the Randles-Ševćik equation. These results emphasize a diffusion-controlled oxidation process of AMS which agreed with the previous studies [ 16 , 17 ]. Additionally, the relationship between the peak potential E and the logarithm of the scan rate (log ʋ ) was plotted producing a linear regression equation as follows: …”

Section: Resultssupporting

confidence: 93%

“…Literature has contained several analytical methods for determination of AMS in biological samples, most notably chromatographic [ 6 – 9 ], spectrophotometric [ 10 – 12 ], and spectrofluorometric [ 13 , 14 ]. Also, a few works based on electrochemical methods have been reported for AMS using ion-selective electrode [ 15 ] or unmodified glassy carbon electrode [ 16 ], and modified electrode with fsDNA [ 17 ], or ruthenium nanoparticles [ 18 ]. The electrochemical methods received the most attention owing to their excellent sensitivity, efficiency, accuracy, and cost-effectiveness.…”

Section: Introductionmentioning

confidence: 99%

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NiFe-based Prussian blue analogue nanopolygons hybridized with functionalized glyoxal polymer as a voltammetric platform for the determination of amisulpride in biological samples

El-Zahry

Ali

2023

Anal Bioanal Chem

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A novel voltammetric platform based on pencil graphite electrode (PGE) modification has been proposed, containing bimetallic (NiFe) Prussian blue analogue nanopolygons decorated with electro-polymerized glyoxal polymer nanocomposites (p-DPG NCs@NiFe PBA Ns/PGE). Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and square wave voltammetry (SWV) were utilized to investigate the electrochemical performance of the proposed sensor. The analytical response of p-DPG NCs@NiFe PBA Ns/PGE was evaluated through the quantity of amisulpride (AMS), one of the most common antipsychotic drugs. Under the optimized experimental and instrumental conditions, the method showed linearity over the range from 0.5 to 15 × 10−8 mol L−1 with a good correlation coefficient (R = 0.9995) and a low detection limit (LOD) reached, 1.5 nmol L−1, with excellent relative standard deviation for human plasma and urine samples. The interference effect of some potentially interfering substances was negligible, and the sensing platform demonstrated an outstanding reproducibility, stability, and reusability. As a first trial, the proposed electrode aimed to shed light on the AMS oxidation mechanism, where the oxidation mechanism was monitored and elucidated using the FTIR technique. It was also found that the prepared p-DPG NCs@NiFe PBA Ns/PGE platform had promising applications for the simultaneous determination of AMS in the presence of some co-administered COVID-19 drugs, which could be attributed to the large active surface area, and high conductivity of bimetallic nanopolygons. Graphical Abstract

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

NiFe-based Prussian blue analogue nanopolygons hybridized with functionalized glyoxal polymer as a voltammetric platform for the determination of amisulpride in biological samples

El-Zahry

Ali

2023

Anal Bioanal Chem

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“…25,26 In literature, HSA-drug interaction has been investigated electrochemically with GCE in different drugs classification such as Parkinson's disease, 27 antibiotics, 28 antitumor, 29 and antipsychotic. 30 DNA-drug interaction has been investigated electrochemically in different drugs and chemicals with a classification such as anticancer, 31,32 antidiabetic, 33,34 antipsychotic, 35 antidepressant, 36 anti-inflammatory. 37 To our knowledge, this is the first electrochemical study on the interaction of MIL with DNA and HSA.…”

Section: Supplementary Materials For This Article Is Available Onlinementioning

confidence: 99%

Phosphodiesterase-3 Enzyme Inhibitor Drug Milrinone Interaction with DNA and HSA: Electrochemical, Spectroscopic and Molecular Docking

Ünal¹,

Erkmen²,

Selcuk³

et al. 2022

J. Electrochem. Soc.

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In this study, the interaction between the phosphodiesterase-3 enzyme inhibitor drug milrinone and biomolecules was investigated by electrochemical, fluorescence spectroscopy, and molecular docking studies for the first time. The interaction between milrinone and biomolecules was investigated according to the decrease in deoxyguanosine oxidation signals of milrinone and calf thymus double-stranded deoxyribonucleic acid (ct-dsDNA) by cyclic voltammetry and differential pulse voltammetry. In fluorescence spectroscopy studies, a competitive study was conducted on ct-dsDNA by adding a well-known fluorescent methylene blue and ct-dsDNA solution. The fluorescent results showed that milrinone had a higher affinity for ct-dsDNA binding compared to methylene blue. Interaction studies show that milrinone binds to ct-dsDNA via a groove-binding mode, and the binding constant values were calculated as 4.27 × 106 M-1 and 6.03 × 104 M-1 at 25 °C, based on cyclic voltammetry and spectroscopic results, respectively. As a result of the interaction of human serum albumin and milrinone, the binding coefficient was calculated as 4.11 × 106 M-1 by cyclic voltammetry. In addition, experimental results were confirmed by obtaining information about the possible spatial structure of the aggregate formed through theoretical calculations based on energy minimization for milrinone- ct-dsDNA and milrinone-human serum albumin mixtures with molecular insertion.

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“…The investigations of the interactions are depending on the differences in the electrochemical behaviour of DNA such as the decreases/increases of the peak currents and the dislocations of the potentials associated with guanine and adenine. DNA modified probes offer great sensitivity for the detection of even small changes in the structure of DNA and have been successfully used to describe the interaction of the anticancer drugs with DNA .…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Determination of the Effect of Caffeic Acid onto the Interaction between Idarubicin and DNA by Single‐use Disposable Electrodes

Öndeş

Muti

2020

Electroanalysis

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Now it is well known, antioxidant may affect the interaction of anticancer drugs and DNA. This study aims to investigate the interaction between Idarubicin and DNA and the effect of caffeic acid on this interaction. Disposable, inexpensive, easy handle electrodes were used in this study to investigate the interaction of idarubicin and DNA electrochemically. Idarubicin (IDR) is an anthracyline antitumor antibiotic, which used against one or more types of leukemia. Electrochemical behaviour of IDR was investigated by using cyclic voltammetry. The interaction between anticancer drug, IDR and calf thymus double‐stranded DNA (ctdsDNA) was investigated by using differential pulse voltammetry (DPV) technique in the absence and presence of caffeic acid.

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Anodic Voltammetric Determination of an Atypical Antipsychotic Drug Amisulphide in Pharmaceutical Dosage Forms Using Electrochemical fsDNA Biosensor

Cited by 6 publications

References 29 publications

NiFe-based Prussian blue analogue nanopolygons hybridized with functionalized glyoxal polymer as a voltammetric platform for the determination of amisulpride in biological samples

NiFe-based Prussian blue analogue nanopolygons hybridized with functionalized glyoxal polymer as a voltammetric platform for the determination of amisulpride in biological samples

Phosphodiesterase-3 Enzyme Inhibitor Drug Milrinone Interaction with DNA and HSA: Electrochemical, Spectroscopic and Molecular Docking

Electrochemical Determination of the Effect of Caffeic Acid onto the Interaction between Idarubicin and DNA by Single‐use Disposable Electrodes

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