Anodized titanium with calcium and phosphorus surface enhancements for dental and orthopedic implant applications

Nelson, Jiman; Jain, Sakshi; Pal, Pallabi; Johnson, H. A.; Nobles, Kadie P.; Janorkar, Amol V.; Williamson, S; Roach, Michael D.

doi:10.1016/j.tsf.2022.139117

Cited by 8 publications

(1 citation statement)

References 37 publications

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“…These nanoscale modifications in the range of 1–100 nm can increase protein attachment, enhance bone-implant contact, and improve osseointegration [ 63 ]. Acid etching, electrochemical anodization, and lithography can be used to fabricate nano-topography on Ti [ 64 ]. It is important to recognize that among these strategies, electrochemical anodization has been found to be the most reliable, cost-effective, and scalable technique to fabricate nanostructures on the surface of the Ti implants, such as titanium oxide (TiO 2 ) nanotubes (NT) [ 65 ].…”

Section: Conventional Drug-eluting Implantsmentioning

confidence: 99%

Recent Advancements in Metallic Drug-Eluting Implants

et al. 2023

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Over the past decade, metallic drug-eluting implants have gained significance in orthopedic and dental applications for controlled drug release, specifically for preventing infection associated with implants. Recent studies showed that metallic implants loaded with drugs were substituted for conventional bare metal implants to achieve sustained and controlled drug release, resulting in a desired local therapeutic concentration. A number of secondary features can be provided by the incorporated active molecules, including the promotion of osteoconduction and angiogenesis, the inhibition of bacterial invasion, and the modulation of host body reaction. This paper reviews recent trends in the development of the metallic drug-eluting implants with various drug delivery systems in the past three years. There are various types of drug-eluting implants that have been developed to meet this purpose, depending on the drug or agents that have been loaded on them. These include anti-inflammatory drugs, antibiotics agents, growth factors, and anti-resorptive drugs.

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Section: Conventional Drug-eluting Implantsmentioning

confidence: 99%