Anogenital malignancies and premalignancies: Facts and controversies

Kutlubay, Zekayі; Engın, Burhan; Zara, Tuba; Tüzün, Yalçın

doi:10.1016/j.clindermatol.2013.01.003

Cited by 45 publications

(52 citation statements)

References 53 publications

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“…The debate on the likelihood of recurrence in HPV-associated carcinomas is controversial: Lanneau et al points out that younger patients often smoke and have HPV infections [20]. Tobacco consumption and HPV infection increase the risk of developing vulvar cancer [21,22,23], and the persistence of these factors also possibly increases the risk of recurrence. Recurrence rate is higher in pre-malignancies caused by HPV, but less progression to invasive tumours is observed.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Age on the Prognosis of Vulvar Cancer

Hami

Lampe²,

Mallmann

et al. 2018

Oncol Res Treat

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Introduction: Younger women are particularly affected by the increase in the incidence of vulvar cancer. The purpose of this study was to investigate how clinical characteristics differ depending on the patient´s age and what role the age of initial diagnosis plays in the prognosis. Patients andMethods: Included patients were divided into groups aged below or above 50 years. The disease-free survival (DFS) was calculated and a multivariate discriminant analysis was conducted. Results: Of the 300 patients, 79 were ≤50 years and 221 were >50 years. The median age was 64 years (19-96 years). There were no differences between the groups regarding lymph node (LN) status and distant metastasis, but T1 tumours were more frequent in patients ≤50 years (77% vs. 62%, p = 0.02). The DFS only differed between the groups when there were no LN metastases. The nodal status was the predominant prognostic factor for the DFS regardless of age. In node-free patients, the 5-year DFS was 49% for the ≤50 years group and 89% for the >50 years group (p = 0.008), whereas there was no difference if a LN was involved. Conclusion: In node-free patients, the risk for recurrence is lower for patients older than 50 years.

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Section: Discussionmentioning

confidence: 99%

The Impact of Age on the Prognosis of Vulvar Cancer

Hami

Lampe²,

Mallmann

et al. 2018

Oncol Res Treat

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“…Numerous, large or suspicious lesions have to be biopsied before any further treatment [ 7 ] to rule out malignancies (Fig. 9.9 ).…”

Section: Anogenital Wartsmentioning

confidence: 99%

Cryosurgery for Warts

Buckley

2014

Cryosurgery

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“…Women with vulvar cancer commonly come to medical attention when their cancers are advanced. The cultural and social reasons are complex and include missed diagnoses, embarrassment and denial [2]. This report reviews the demographics, cancer variables, and treatment of women treated at the National Institute of Cancer Research and Hospital (NICRH) and Delta Private Hospital in Dhaka Bangladesh.…”

Section: Introductionmentioning

confidence: 99%

“…Vulvar cancer is reported to be a disease of older women with an average age at diagnosis of 67 years. Over the past decade there has been an increase in vulvar intraepithelial neoplasia (VIN) and VIN-related invasive vulvar cancer in women younger than age 50 years due to its association with Human Papillomavirus (HPV) infections worldwide [2]. In one study utilizing specimens from 39 countries, 2,296 cases of vulvar neoplasia were analyzed for HPV subtypes [3].…”

Section: Introductionmentioning

confidence: 99%

Treatment Outcome of Women with Vulvar Cancer Treated in Bangladesh

Pervin¹,

Goodman²

2013

UCMS

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Vulvar cancer has not been well studied in Bangladesh. This retrospective review reports on the experience of ten women with vulvar cancer who were treated at the National Institute of Cancer Research Hospital and Delta Private Hospital from October 2010 through March 2011. Survival was analyzed by age, stage and grade of the cancers. The ages of ten women with vulvar cancer ranged from 45 years to 70 years with a median of 59 years. The majority of patients (nine) presented with stage III disease. One patient had a stage II cancer. Nine women had squamous cell cancers and one had an adenocarcinoma of the Bartholin's gland. All patients underwent surgery and nine underwent either preoperative or postoperative radiation therapy. At 24 months of follow-up, eight patients are currently alive and disease free.

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Anogenital malignancies and premalignancies: Facts and controversies

Cited by 45 publications

References 53 publications

The Impact of Age on the Prognosis of Vulvar Cancer

The Impact of Age on the Prognosis of Vulvar Cancer

Cryosurgery for Warts

Treatment Outcome of Women with Vulvar Cancer Treated in Bangladesh

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