Anoikis resistance and oncoviruses

Kakavandi, Ehsan; Shahbahrami, Ramin; Goudarzi, Hossein; Eslami, Gita; Faghihloo, Ebrahim

doi:10.1002/jcb.26363

Cited by 73 publications

(55 citation statements)

References 77 publications

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“…It has been reported that the LMP1 down-regulates the E-cadherin expression and up-regulates TWIST and other transcription factors linked to the cell motility [69,70]. The EBV-protein, LMP-1, leads to anoikis resistance by inducing the expression of anti-apoptosis proteins survivin, CD44, the inhibitor of DNA binding 1 (Id1), Bim and ROS [63,71]. Moreover, the co-expression of E6 and LMP1 triggers some processes, including tumor-formation ability, anchorage-independent growth, resistance to apoptosis and cell proliferation, in nude mice when comparing with the expression of E6 or EBNA1 alone [72].…”

Section: Discussionmentioning

confidence: 99%

Anoikis Resistance and Development in Prostate Cancer: The Possible Role of HPV/EBV Coinfection

Nahand

Khanaliha

Mirzaei

et al. 2021

Preprint

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Background: This study aimed to evaluate the possible role of EBV/HPV co-infection as an etiologic factor in prostate cancer (PCa) development.Methods: The present case‐control research was conducted on 67 cases with prostate cancer and 40 controls. The expression of cellular and viral factors involved in inflammation, tumor progression, and metastasis were quantitated using ELISA and qRT-PCR.Results: The EBV/HPV co-infection was reported in 14.9% of case group and 7.5% of control group. The high-risk type of HPV, including HPV 16 and 18, were responsible for 50% and 30% of 10 HPV/EBV co-infected PCa samples, respectively. According to the results, a significant relationship was not observed between the PCa and HPV/EBV co-infection (OR=2.9, 95%CI=0.18-45.2, P=0.31). However, the highest percentage of HPV genome integration was found in HPV/EBV coinfected PCa group (8/10, 80%). Moreover, the mean expression levels of inflammatory factors (IL-17, IL-6, TNF-α, NF-κB, VEGF, ROS and RNS), anti-apoptotic mediators (Bcl-2 and Survivin), and anti-anoikis factors (TWIST, N-cad) were higher significantly in the HPV/EBV co-infected PCa cases when comparing with the non-coinfected PCa samples. Nevertheless, the tumor suppressor proteins (p53 and Rb) and the E-cad (inhibiting anoikis resistance) had a significant downregulation in the HPV/EBV co-infected PCa cases than in the non-coinfected PCa samples. Conclusion: HPV/EBV co-infection probably can act as an etiologic factor in PCa through modulation of cellular behavior.

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Section: Discussionmentioning

confidence: 99%

Anoikis Resistance and Development in Prostate Cancer: The Possible Role of HPV/EBV Coinfection

Nahand

Khanaliha

Mirzaei

et al. 2021

Preprint

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“…As mentioned earlier, anoikis is known as a physiologic process that is involved in removing of the detachment cells. Inhibition of anoikis is one of the important mechanisms in cancer invasiveness and metastasis that can be performed by viruses (Kakavandi et al, ). We found that the expression levels of LMP‐1, LMP‐2A, and EBERs were higher in tumor tissue and the EBV‐positive group compared with healthy tissues and the EBV‐negative group (Table and Figure ).…”

Section: Discussionmentioning

confidence: 99%

Epstein–Barr virus and thyroid cancer: The role of viral expressed proteins

Moghoofei

Mostafaei

Nesaei

et al. 2018

Journal Cellular Physiology

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Background: Thyroid cancer is a common endocrine malignancy whose incidence has increased in recent years. Several internal and external risk factors are involved in the development of this cancer, such as infectious agents. Evidence supporting the role of viral infection as an etiology for the invasiveness of thyroid cancer is increasing. The aim of this study was to determine the presence of the Epstein-Barr virus (EBV) and the association between viral gene products and thyroid tumor development.Methods: Fifty-seven thyroid cancer specimens were collected from the same number of patients as well as 18 samples from healthy controls. The presence of the EBV genome and the genotyping was examined by polymerase chain reaction (PCR).Also, an enzyme-linked immunosorbent assay and real-time PCR were used to measure the expression levels of viral and cellular genes.Results: The EBV DNA was detected in 71.9% of the samples, and it was also found that the presence of the EBV was associated with increasing development of thyroid tumor. Conclusion:Our results demonstrated that EBV infection may play a role in the development of thyroid tumor. K E Y W O R D Sanoikis, Epstein-Barr virus, inflammation, thyroid cancer, tumor development

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“…However, scientific evidence linking viral infections to tumor development has increased ( 296 ). Currently, between 15% and 20% of neoplasms are considered to be related to primary viral infections ( 297 ). These oncogenic viruses integrate into the host cell genome and utilize host signaling pathways to regulate cell proliferation and differentiation, genomic stability, apoptosis, and immune system recognition ( 298 , 299 ).…”

Section: Autophagy During Viral Infectionmentioning

confidence: 99%

Autophagy in Viral Development and Progression of Cancer

2021

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Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic components for subsequent degradation through lysosomal hydrolases. Although this catabolic process can be triggered by a great variety of stimuli, action in cells varies according to cellular context. Autophagy has been previously linked to disease development modulation, including cancer. Autophagy helps suppress cancer cell advancement in tumor transformation early stages, while promoting proliferation and metastasis in advanced settings. Oncoviruses are a particular type of virus that directly contribute to cell transformation and tumor development. Extensive molecular studies have revealed complex ways in which autophagy can suppress or improve oncovirus fitness while still regulating viral replication and determining host cell fate. This review includes recent advances in autophagic cellular function and emphasizes its antagonistic role in cancer cells.

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Anoikis resistance and oncoviruses

Cited by 73 publications

References 77 publications

Anoikis Resistance and Development in Prostate Cancer: The Possible Role of HPV/EBV Coinfection

Anoikis Resistance and Development in Prostate Cancer: The Possible Role of HPV/EBV Coinfection

Epstein–Barr virus and thyroid cancer: The role of viral expressed proteins

Autophagy in Viral Development and Progression of Cancer

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