Anomalies chromosomiques du spermatozoïde

Rives, Nathalie; Mousset-Siméon, N.; Sibert, L.; Duchesne, Véronique; Macé, L.; Milazzo, J. P.; Mazurier, Sophie; Macé, Bertrand

doi:10.1016/j.gyobfe.2004.07.005

Cited by 5 publications

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References 62 publications

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“…Men with severe oligozoospermia have an elevated risk for chromosome abnormalities in their spermatozoa, particularly sex chromosome anomalies (Martin et al, 2003a). It is now well established that spermatozoa aneuploidy is negatively correlated to the sperm count in infertile males (for review, Rives et al, 2004). During spermatogenesis in males with sperm alterations, a decreased frequency of meiotic chromosome pairing and crossing over may lead to spermatogenesis arrest at the pachytene stage responsible for haploid germ cell depletion and oligozoospermia, as well as to an increase of meiotic nondisjunctions leading to spermatozoa aneuploidy Gonsalves et al, 2004;Sun et al, 2004).…”

confidence: 99%

Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: asthenozoospermia

Rives

2005

Cytogenet Genome Res

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The aim of aneuploidy evaluation in spermatozoa from patients presenting spermatogenesis defects is to identify a relationship between meiotic errors and quantitative or qualitative alterations of spermatogenesis. During the past ten years, the use of fluorescence in situ hybridization (FISH) has permitted the determination of the frequency of numerical chromosome aberrations in different clinical situations. It has been established that infertile males with reduced sperm count and a normal constitutional karyotype have a significantly high risk of aneuploidy in their spermatozoa particularly regarding sex chromosomes. Concerning sperm motility, the data are more controversial. However, patients of severe asthenozoospermia induced by specific morphological deformities involving sperm flagella have a significantly high risk of producing aneuploid spermatozoa.

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