Primitive sarcomas of the gall bladder are extremely uncommon. Leiomyosarcoma, an unusual disorder of the sarcomas, is more prevalent in women. Its definitive diagnosis relies on immunohistochemical examination. We report a case of this rare disorder, i.e., a malignant tumour in the gall bladder, and also discuss different epidemiological and radiological aspects, as well as therapeutic strategies. To cite this journal: Oncologie 12 (2010).