Anomalous Cerebellar Anatomy in Chinese Children with Dyslexia

Yang, Ying-Hui; Yang, Yang; Chen, Baoguo; Zhang, Yi-Wei; Bi, Hong‐Yan

doi:10.3389/fpsyg.2016.00324

Cited by 21 publications

(12 citation statements)

References 96 publications

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“…Notably, when investigating anatomical structure, Yang, Yang, Chen, Zhang, and Bi observed reduced gray matter volume in the left cerebellum of Chinese-speaking children with DD relative to controls. 31 Feng et al further explored cerebrocerebellar functional connectivity and suggested atypical connectivity patterns existed between the left cerebellum and the left fusiform gyrus during orthographic processing, whereas increased connectivity between the right cerebellum and the left supramarginal gyrus was found during phonological processing. 32 However, in the present study, the integrity of the right cerebellar tracts was significantly associated with the children's performance of character recognition.…”

Section: Discussionmentioning

confidence: 99%

Specifying the diffusion MRI connectome in Chinese-speaking children with developmental dyslexia and auditory processing deficits

Wang

Yeh

2019

Pediatrics & Neonatology

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The study provides evidence that the dysconnectivity on white matter pathways correlated with developmental dyslexia in Chinese-speaking children. Furthermore, the impairments of auditory temporal timing processing presented in poor readers with significant phonological deficits are likely to be a result of impoverished myelinization in sub-cortical tracts. Such findings may assist in the clinical identification of Chinese developmental dyslexia.

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Section: Discussionmentioning

confidence: 99%

Specifying the diffusion MRI connectome in Chinese-speaking children with developmental dyslexia and auditory processing deficits

Wang

Yeh

2019

Pediatrics & Neonatology

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“…The neural anomalies found in studies of RD in Chinese readers vary in terms of their consistency with those identified in alphabetic languages. For example, while some researchers found that Chinese RD children show atypical anatomy in left TPC (Xia, Hoeft, Zhang, & Shu, ) and the cerebellum (Yang, Yang, Chen, & Bi, ), similar to that reported in studies that have examined English RD, others report anomalies in areas such as the left middle frontal gyrus (Siok, Niu, Jin, Perfetti, & Tan, ), which are not associated with RD in studies of alphabetic languages. Notably, Chinese RD has been specifically associated with anomalies in the left middle frontal gyrus and the superior parietal lobule, which may reflect larger semantic and visuospatial demands, and heavier working memory load associated with the logographic system (Siok, Perfetti, Jin, & Tan, ; Siok, Spinks, Jin, & Tan, ; Siok et al, ; Xu, Yang, Siok, & Tan, ).…”

Section: Cross‐linguistic Comparisonsmentioning

confidence: 72%

Neurobiological bases of reading disorder Part I: Etiological investigations

Xia

Hancock²,

Hoeft

2017

Language and Linguist. Compass

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While many studies have focused on identifying the neural and behavioral characteristics of decoding-based reading disorder (RD, aka developmental dyslexia), the etiology of RD remains largely unknown and understudied. Because the brain plays an intermediate role between genetic factors and behavioral outcomes, it is promising to address causality from a neural perspective. In the current, Part I of the two-part review, we discuss neuroimaging approaches to addressing the causality issue and review the results of studies that have employed these approaches. We assume that if a neural signature were associated with RD etiology, it would (a) manifest across comparisons in different languages, (b) be experience independent and appear in comparisons between RD and reading-matched controls, (c) be present both pre- and post-intervention, (d) be found in at-risk, pre-reading children and (e) be associated with genetic risk. We discuss each of these five characteristics in turn and summarize the studies that have examined each of them. The available literature provides evidence that anomalies in left temporo-parietal cortex, and possibly occipito-temporal cortex, may be closely related to the etiology of RD. Improved understanding of the etiology of RD can help improve the accuracy of early detection and enable targeted intervention of cognitive processes that are amenable to change, leading to improved outcomes in at-risk or affected populations.

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“…Several studies in DD have investigated differences in brain structure when compared to unimpaired readers using voxel-based morphometry, with or without functional MRI (Brambati et al 2004 ; Brown et al 2001 ; Dole et al 2013 ; Eckert et al 2005 , 2016 ; Evans et al 2014 ; Hoeft et al 2007 ; Jednoróg et al 2014 , 2015 ; Krafnick et al 2014 ; Kronbichler et al 2008 ; Menghini et al 2008 ; Pernet et al 2009a , b ; Raschle et al 2015 ; Silani et al 2005 ; Siok et al 2008 ; Steinbrink et al 2008 ; Tamboer et al 2015 ; Vinckenbosch et al 2005 ; Xia et al 2016 ; Yang et al 2016 ).…”

Section: Discussionmentioning

confidence: 99%

No evidence for cerebellar abnormality in adults with developmental dyslexia

et al. 2018

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Developmental dyslexia is commonly believed to result from a deficiency in the recognition and processing of speech sounds. According to the cerebellar deficit hypothesis, this phonological deficit is caused by deficient cerebellar function. In the current study, 26 adults with developmental dyslexia and 25 non-dyslexic participants underwent testing of reading-related skills, cerebellar functions, and MRI scanning of the brain. Anatomical assessment of the cerebellum was conducted with voxel-based morphometry. Behavioural evidence, that was indicative of impaired cerebellar function, was found to co-occur with reading impairments in the dyslexic subjects, but a causal relation between the two was not observed. No differences in local grey matter volume, nor in structure–function relationships within the cerebellum were found between the two groups. Possibly, the observed behavioural pattern is due to aberrant white matter connectivity. In conclusion, no support for the cerebellar deficit hypothesis or the presence of anatomical differences of the cerebellum in adults with developmental dyslexia was found.Electronic supplementary materialThe online version of this article (10.1007/s00221-018-5351-y) contains supplementary material, which is available to authorized users.

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Anomalous Cerebellar Anatomy in Chinese Children with Dyslexia

Cited by 21 publications

References 96 publications

Specifying the diffusion MRI connectome in Chinese-speaking children with developmental dyslexia and auditory processing deficits

Specifying the diffusion MRI connectome in Chinese-speaking children with developmental dyslexia and auditory processing deficits

Neurobiological bases of reading disorder Part I: Etiological investigations

No evidence for cerebellar abnormality in adults with developmental dyslexia

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