Anomalous migration of central nervous tissue to transplanted autonomic ganglia

Rosenstein, Jeffrey M.; Brightman, Milton W.

doi:10.1007/bf01262412

Cited by 28 publications

(2 citation statements)

References 39 publications

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“…At survival times of 11 and 14 days postoperation, well-defined bundles of orientated, closely mixed Schwann cell, astrocytic and axonal profiles could be observed that were surrounded by a single basal lamina sheath. Some degree of mixing of Schwann cells and astrocytic and/or oligodendrocytic profiles has already been described following experimental demyelinating lesions and after transplantation of autonomic ganglia into the CNS (Blakemore, 1976;Rosenstein and Brightman, 1981;Sims and Gilmore, 1983;Zhou et al, 1986). The coexistence of Schwann cells and astrocytic processes within tightly packed bundles (surrounded by a complete or incomplete basal lamina) suggests that these populations of CNS and PNS glia share some surface properties that can, under certain circumstances, lead to apparent cooperation in the support of regenerative nerve fiber growth.…”

Section: Discussionmentioning

confidence: 98%

Columns of Schwann cells extruded into the CNS induce in-growth of astrocytes to form organized new glial pathways

Brook

Lawrence

Raisman

2001

Glia

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Section: Discussionmentioning

confidence: 98%

Columns of Schwann cells extruded into the CNS induce in-growth of astrocytes to form organized new glial pathways

Brook

Lawrence

Raisman

2001

Glia

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“…Cerebellar Bergman glia have been shown to control the migration of granule cells into the internal granule cell layer (8,16,17). Glial cells located in nerve grafts that had been placed adjacent to migratory granule cells in the external granule cell layer prevent the normal migration of the granule cells along the Bergman glia and cause the cells to migrate into the graft (11,19,20).…”

Section: Discussionmentioning

confidence: 99%

Cerebellar granule cells contain a membrane mitogen for cultured Schwann cells.

Mason

Bigbee

DeVries

1989

The Journal of Cell Biology

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Proliferation of Schwann cells is one of the first events that occurs after contact with a growing axon. To further define the distribution and properties of this axonal mitogen, we have (a) cocultured cerebellar granule cells, which lack glial ensheathment in vivo with Schwann cells; and (b) exposed Schwann cell cultures to isolated granule cell membranes. Schwann cells cocultured with granule cells had a 30-fold increase in the labeling index over Schwann cells cultured alone, suggesting that the mitogen is located on the granule cell surface. Inhibition of granule cell proteoglycan synthesis caused a decrease in the granule cells' ability to stimulate Schwann cell proliferation. Membranes isolated from cerebellar granule cells when added to Schwann cell cultures caused a 45-fold stimulation in [3H]thymidine incorporation. The granule cell mitogenic signal was heat and trypsin sensitive and did not require lysosomal processing by Schwann cells to elicit its proliferative effect. The ability of granule cells and their isolated membranes to stimulate Schwann cell proliferation suggests that the mitogenic signal for Schwann cells is a ubiquitous factor present on all axons regardless of their ultimate state of glial ensheathment.

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Cytoarchitectonics of substantia nigra grafts: A light and electron microscopic study of immunocytochemically identified dopaminergic neurons and fibrous astrocytes

Jaeger

1985

J of Comparative Neurology

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Maturation of dopaminergic (DA) neurons and astroglia was studied in transplants of the substantia nigra grown for up to 7 months in the brain of rats. The investigation had three specific aims. The first was to observe effects of different transplant positions on the longevity of DA neurons. Second, the grafts were examined for changes of synaptic interactions and associations between DA neurons and astroglia. Third, an answer was sought to the question whether transplanted DA neurons migrate into the adjacent host brain. The grafts were taken from the ventral mesencephalon of rat embryos of different ages (day 14 to 18 of gestation) and placed into the cerebral cortex, tectum, cerebellum, or ventricles of newborn host animals. Following different times of survival the immunocytochemical localization of tyrosine hydroxylase (TH) and of glia filament protein (GFA) in the transplants were observed. In all of the transplantation sites, except for one, neurons of different morphologies that contained TH were found in the grafts. The cerebellar white matter of the host brain failed to support the long-term survival of DA neurons. The overall structure of mature substantia nigra grafts had some resemblance to intact substantia nigra (SN). On the ultrastructural level, it was found that morphological expression of some immature features of DA neurons, such as glial sheaths, somatic spines, and lack of oligodendroglia, persisted in mature grafts. Specific associations of DA neurons and astroglia in the grafts suggested that the cytoarchitectonic appearance of a given brain region may be related to the existence of particular neuron glia relationships. In contrast to intact SN, transplants revealed deficiencies in unlabeled pleomorphic boutons and contained some TH-immunoreactive terminals. Migration of DA neurons and their processes into the adjacent host brain was rarely observed.

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Anomalous migration of central nervous tissue to transplanted autonomic ganglia

Cited by 28 publications

References 39 publications

Columns of Schwann cells extruded into the CNS induce in-growth of astrocytes to form organized new glial pathways

Columns of Schwann cells extruded into the CNS induce in-growth of astrocytes to form organized new glial pathways

Cerebellar granule cells contain a membrane mitogen for cultured Schwann cells.

Cytoarchitectonics of substantia nigra grafts: A light and electron microscopic study of immunocytochemically identified dopaminergic neurons and fibrous astrocytes

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