C ongenital anomalies of coronary arteries are rare, insofar as they are seen upon coronary angiography at a rate of approximately 1%.1 Anomalous origin of the left main coronary artery (LMCA) with subsequent intramural coursing between the ascending aorta and the main pulmonary artery (PA) is certainly even rarer.2 In young people engaged in strenuous exercise, this condition commonly results in myocardial ischemia, ventricular arrhythmia, and sudden cardiac death. We report such a case in which the result was favorable.
Case ReportIn March 2011, an 18-year-old woman suddenly lost consciousness and collapsed upon completion of a 10-km run at her university's annual campus marathon. She had not been trained for running in accordance with any protocol, and this was her first time to expend such a level of effort. She had not experienced any symptoms before the event.In our emergency department, a 15-to 20-min course of cardiopulmonary resuscitation and electrical shock for ventricular fibrillation (Fig. 1A) enabled a return of spontaneous circulation (ROSC), and the patient was admitted to our medical intensive care unit (MICU).In the MICU, she was unconscious and her systemic pressure remained low (~80/50 mmHg), despite a high intravenous dose of an inotropic agent. Her jugular venous pressure was elevated, and her body temperature was 36 °C. A 12-lead electrocardiogram (ECG) obtained 20 minutes after ROSC showed sinus tachycardia with nonspecific ST-T changes and no prolonged QTc interval (QTc, 446 ms) (Fig. 1B). Her initial arterial blood gas analysis showed hypoxia with respiratory and metabolic acidosis. The chest radiograph taken immediately after admission to the MICU showed a normal heart size with bilateral pulmonary edema, similar to a pattern of acute respiratory distress syndrome. A transthoracic echocardiogram (TTE) taken 2 hours after her admission to the MICU revealed a normal left ventricular (LV) chamber size with diffuse hypokinesia and an LV ejection fraction (LVEF) of approximately 0.30. No pericardial effusion was found. The initial complete blood counts, the blood chemistry results, and the toxicology screen were all normal. An intra-aortic balloon pump (IABP)-inserted about 3 hours after admission to the MICU-subsequently assisted, over the course of 4 days, with extracorporeal membrane oxygenation (ECMO) for cardiogenic shock.The patient's general condition improved substantially after therapeutic hypothermia, and she awoke on the 3rd day of hospitalization. On the 4th and 5th days, she was successfully weaned from the ECMO, the IABP, and the mechanical ventilator.