Objective: Anomalous origin of the pulmonary artery from the aorta (AOPA) is a rare cardiac anomaly. This study aimed to define the clinical characteristics, diagnostic features, management, and follow-up of pediatric patients diagnosed with AOPA. Material and Methods: We retrospectively reviewed children diagnosed with AOPA from 2010 to 2023. Results: Thirteen children were diagnosed with AOPA over the study period. Seven patients were male (53.8%). At the initial examination, the patients' ages ranged from 11 days to 16 years, and their weights ranged from 3 to 43 kg. The anomalous branch was the right pulmonary artery in 10 patients and the left pulmonary artery in three patients. Five patients underwent catheter angiography, and nine underwent CT. In one patient, the diagnosis was misdiagnosed by the initial echocardiography, and the correct diagnosis was made by CT. Surgical correction of AOPA and associated cardiac abnormalities were performed in five patients. The time of surgery was a median of 2.5 months (range, 27 days-9 months). There were no peri/postoperative in-hospital deaths. Balloon angioplasty was performed in one patient due to significant RPA stenosis in the postoperative 4 th year. The median follow-up was 33 months (14-140 months). Conclusion: AOPA is a rare structural heart disease and can be accompanied by other complex congenital pathologies. Advanced multimodality imaging techniques can be used to not overlook the diagnosis of AOPA. Early diagnosis and prompt surgical repair of AOPA result in excellent survival and avoid the development of pulmonary vascular obstructive disease.