Anomalous Origins of Bilateral Vertebral Arteries in a Child with down Syndrome and Moyamoya Disease

Mishra, Atul; Pendharkar, Hima; Jayadaevan, E.R.; Bodhey, N.K.

doi:10.1177/159101991201800303

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…Prior studies have demonstrated a higher incidence of vascular anomalies in patients with Down syndrome; in fact, Rathore et al showed that the incidence of VA anomalies and aberrant RSCA in patients with Down syndrome is 40% and 36%, respectively [4,18- 19]. The case we report demonstrates both an aberrant RSCA and an anomalous origin of the right VA from the right CCA in a patient with Down syndrome.…”

Section: Discussionsupporting

confidence: 45%

Anomalous Origin of the Right Vertebral Artery from the Right Common Carotid Artery

Ali

Román

Cox

et al. 2018

Cureus

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The anomalous origin of the right vertebral artery (VA) from the right common carotid artery (CCA) is a rare vascular anomaly, which is usually clinically asymptomatic and found incidentally during angiographic examinations. This anomaly is invariably associated with an aberrant right subclavian artery (RSCA). Approximately 31 cases have been reported in the literature. We present a case of a right VA originating from the right CCA in a patient with Down syndrome and discuss the imaging findings, embryological etiology of the anomaly, as well as its implications for endovascular/surgical treatment.

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Section: Discussionsupporting

confidence: 45%

Anomalous Origin of the Right Vertebral Artery from the Right Common Carotid Artery

Ali

Román

Cox

et al. 2018

Cureus

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“…A potential etiological – pathogenetic link between the two entities or a common underlying chromosomal abnormality has been proposed 5. Mischra et al 6 reported a case with a very similar arterial disposition but without segmental absence of the VA and same clinical background, MMS with associated DS, that they named MM “disease” . In the current report, we preferred the term MMS based on the association with another medical condition (DS) 7.…”

Section: Discussionmentioning

confidence: 99%

Republished: Multiple anomalies in the origin and course of vertebral arteries and aberrant right subclavian artery in a child with moyamoya syndrome

Beyaz¹,

Khan

Baltsavias

2018

J NeuroIntervent Surg

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Here we report, for the first time, a combination of five-vessel aortic arch, anomalous origin of the right vertebral artery (VA) from the common carotid artery (CCA), an aberrant right subclavian artery (SCA), and bilateral symmetrical segmental agenesis of VAs.In this case report, we present a patient with moyamoya syndrome (MMS) and Down syndrome (DS) who has bilateral symmetrical segmental agenesis of VAs, left VA originating from aortic arch and anomalous origin of right VA arising from CCA in combination with an aberrant right SCA. Therefore, five vessels are originating from aortic arch. Here, we report, for the first time, a combination of five-vessel aortic arch with an aberrant right SCA and symmetrical segmental agenesis of both VAs. The possible embryological mechanisms of the anomalies as well as an relation with MMS and DS are discussed.

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“…During embryological development, the VA develops from the longitudinal anastomosis of the intersegmental arteries [ 11 , 12 ]. An abnormal development of the caudal portion of the intersegmental artery leads to the formation of a VA with an aortic origin which, in turn, may lead to an increased risk of developing VAH compared to a person with a normal VA [ 27 , 28 ]. In an autopsy study, the prevalence of VAs with an aortic origin was reported to be 2-6% [ 14 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Are the anomalous vertebral arteries more hypoplastic?: retrospective linear mixed model approach

2017

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BackgroundSmall or hypoplastic vertebral artery (VA) is one of the risk factor for posterior circulation stroke. We assess whether various types of VA anomaly contribute to its diameter.MethodsWe screened 238 patients who underwent neck CT and MR angiography within 1 month. A V1 anomaly was defined as the abnormal origin of the VA on a three-dimensional MR angiography and a V2 anomaly was defined as the VA not passing through the 6th cervical transverse foramen (TF) on an axial CT image. A linear mixed model was used to evaluate the determinants of VA size.ResultsAmong participants, 24 (10.1%) subjects exhibited an anomalous VA and, of the 476 VAs examined, 11 (2.3%) had an aortic origin and 27 (5.7%) had an abnormal entrance into the C6 TF. Presence of the V1 anomaly was positively associated with the V2 anomaly (P for chi-square < 0.001) and a linear mixed model revealed that being male (0.2 mm larger, P = 0.015), having a right VA anomaly (0.3 mm smaller, P < 0.001), having a V1 anomaly (0.9 mm smaller, P < 0.001), and having a V2 anomaly (0.7 mm smaller, P < 0.001) were significant predictor of VA diameter.ConclusionThe diameters of VAs with an anomalous aortic origin or an abnormal entrance of the TF were significantly smaller than those of normal VAs. These findings suggest that anomalies of the VA detected in 3-dimensional CTA or MRA may be clues for vertebral artery hypoplasia.Electronic supplementary materialThe online version of this article (10.1186/s12883-017-0951-x) contains supplementary material, which is available to authorized users.

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Anomalous Origins of Bilateral Vertebral Arteries in a Child with down Syndrome and Moyamoya Disease

Cited by 8 publications

References 10 publications

Anomalous Origin of the Right Vertebral Artery from the Right Common Carotid Artery

Anomalous Origin of the Right Vertebral Artery from the Right Common Carotid Artery

Republished: Multiple anomalies in the origin and course of vertebral arteries and aberrant right subclavian artery in a child with moyamoya syndrome

Are the anomalous vertebral arteries more hypoplastic?: retrospective linear mixed model approach

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