Anomalous temperature dependence of gas chromatographic retention indices of polar compounds on non-polar stationary phases

Pavlovskii, A. A.; Héberger, Károly; Зенкевич, И. Г.

doi:10.1016/j.chroma.2016.03.079

Cited by 10 publications

(1 citation statement)

References 24 publications

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“…The small numbers do not diminish the importance of the effect. The same is true for the temperature anomalies of GC-RIs of polar compounds on non-polar stationary phases caused by dynamic modification of the stationary phase by analytes [15].…”

Section: Resultsmentioning

confidence: 99%

Unusual Regularity in GC Retention of Simple Amino Acid Derivatives

Зенкевич

Todua

Mikaia

2019

CCHG

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Background: Application of simple regularities and general principles along with direct use of reference gas chromatography retention index data for reliable structure determination of compounds can be enhanced by determination of new regularities that are specific to certain structural elements. Objective: Revelation and interpretation of an anomaly in the elution order of alkyl esters of alkoxycarbonyl derivatives of glycine and alanine on standard and semi-standard non-polar phases. Method: Preliminary derivatization of amino acids to alkyl esters of N-alkoxycarbonyl analogs and interpretation of their gas chromatographic characteristics. Results: Alkyl esters of N-alkoxycarbonyl derivatives of alanine (Alkyl = C2H5, n- and iso-C3H7) elute prior to the same derivatives of glycine, despite the presence of an additional methyl group at C(2) in the molecule. Elution order is reversed for methyl esters of N-methoxycarbonyl derivatives. Conclusion: It is established that the peculiar behavior of alkyl esters of N-alkoxycarbonyl derivatives of glycine and alanine agrees with the concepts of gas chromatography and the known retention index regularities of organic compounds. A decrease of retention index values is a result of an introduction of an additional methyl group to a carbon atom connected to two polar fragments in a molecule like CH2XY. The dependence of the difference of retention index values for homologs of the types of CH3-CHXY and CH2XY vs. the total mass of fragments (X + Y) is similar to those for other sub-groups of analytes.

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Section: Resultsmentioning

confidence: 99%