Problem statement:This study presents an effective method for removing mixed artifacts (EOG-Electro-ocular gram, ECG-Electrocardiogram, EMG-Electromyogram) from the EEGElectroencephalogram records. The noise sources increases the difficulty in analyzing the EEG and obtaining clinical information. EEG signals are multidimensional, non-stationary (i.e., statistical properties are not invariant in time), time domain biological signals, which are not reproducible. It is supposed to contain information about what is going on in the ensemble of excitatory pyramidal neuron level, at millisecond temporal resolution scale. Since scalp EEG contains considerable amount of noise and artifacts and exactly where it is coming from is poorly determined, extracting information from it is extremely challenging. For this reason it is necessary to design specific filters to decrease such artifacts in EEG records. Approach: Some of the other methods that are really appealing are artifact removal through Independent Component Analysis (ICA), Wavelet Transforms, Linear filtering and Artificial Neural Networks. ICA method could be used in situations, where large numbers of noises need to be distinguished, but it is not suitable for on-line real time application like Brain Computer Interface (BCI). Wavelet transforms are suitable for real-time application, but there all success lies in the selection of the threshold function. Linear filtering is best when; the frequency of noises does not interfere or overlap with each other. In this study we proposed adaptive filtering and neuro-fuzzy filtering method to remove artifacts from EEG. Adaptive filter performs linear filtering. Neuro-fuzzy approaches are very promising for non-linear filtering of noisy image. The multipleoutput structure is based on recursive processing. It is able to adapt the filtering action to different kinds of corrupting noise. Fuzzy reasoning embedded into the network structure aims at reducing errors when fine details are processed. Results: The computational result shows that the artifacts from the EEG are removed to a great extent and this has led to the accurate analysis and diagnosis of the EEG related diseases. Conclusion: Experimental results show that the proposed neuro-fuzzy technique is very effective and performs significantly better. The fidelity of the reconstructed EEG signal is assessed quantitatively using parameters such as Signal to Noise Ratio (SNR) and Power Spectral Density (PSD). In addition we have also compared the performance of adaptive filter and neuro-fuzzy filter based on the above parameters.