We investigate 't Hooft anomalies in the CP N −1 model in spacetime dimensions higher than two and identify two types of anomalies: One is a mixed anomaly between the PSU(N ) flavor-rotation and magnetic symmetries, and the other is between the reflection and magnetic symmetries. The latter indicates that even in the absence of the flavor symmetry, the model cannot have a unique gapped ground state as long as the reflection and magnetic symmetries are respected. We also clarified the condition for the 't Hooft anomalies to survive under monopole deformations, which explicitly break the magnetic symmetry down to its discrete subgroup. Besides, we explicitly show how the identified 't Hooft anomalies match in the low-energy effective description of symmetry broken phases-the Néel, U(1) spin liquid, and the valence bond solid phases. An application to the finite-temperature phase diagram of the four-dimensional CP N −1 model is also discussed.