The Perception of Anomie Scale (PAS) is a measure used to evaluate the state of society and whether it is disintegrated and deregulated. Although widely used, the psychometric properties of reliability, validity, and measurement invariance according to sex have not been studied in the Chilean university population. To explore these properties, a cross-sectional study was carried out with 383 students from public (45.7%) and private (54.3%) universities, with a mean age of 21.5 years (SD = 3.3). A CFA and ESEM were performed, which confirmed the two-factor correlated structure, achieving better goodness-of-fit indices by eliminating five items (RMSEA = 0.09; CFI = 0.98; TLI = 0.95). This also provided evidence of reliability and measurement invariance according to sex. This study provides evidence of the psychometric quality of the PAS scale, thus allowing its use in the Chilean university context.