Anophthalmic socket- A cosmetic dilemma

Dhillon, Hennaav Kaur; Raj, Anuradha; Dhasmana, Renu; Bahadur, Harsh

doi:10.18231/2455-8478.2018.0004

Cited by 3 publications

(5 citation statements)

References 7 publications

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“…Also, delay in use of prosthesis and multiple excision of pyogenic granuloma have been described as a cause of contracted socket. 10,11 We have evaluated all causes of contracted socket , and anophthalmia secondary to enucleation/evisceration was found to be the most common cause in our study (33.3%).…”

Section: Discussionmentioning

confidence: 72%

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Clinical use of cryopreserved ultra-thick human amniotic membrane for anophthalmic socket contracture

AlSemari,

AlZahrani,

Ahad

et al. 2023

European Journal of Ophthalmology

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Purpose To study the use of ultra-thick human amniotic membrane for management anophthalmic socket contracture. Methods A prospective study done at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Thirty-six patients (45 eyelids) were involved. Contracted socket caused by trauma, previous surgery or radiotherapy, delay in use of prosthesis, Congenital Anophthalmia/Microphthalmia, and Anophthalmia secondary to Enucleation/Evisceration were included in the study. Results Thirty-three patients (42 eyelids) underwent fornix reconstruction with cryopreserved ultra-thick human amniotic membrane. Mean ± SD age at surgery was (40.90 ± 17.32) years. Mean follow up was 10.5 months. Grade II fornix contracture was the most common type in 23 (54.8%) eyelids. The most common involved primary diagnosis was Anophthalmia secondary to Enucleation/Evisceration (n = 13). The incidence of pyogenic granuloma (PG) after surgery was seen in 8 eyelids (19.0%). Conclusion Anophthalmic contracted socket secondary to significant history of multiple PG excision (> 5 times) and secondary to enucleation/evisceration were associated with good surgical outcome. Cryopreserved ultra-thick human amniotic membrane is an ideal material for the management of anophthalmic socket contracture.

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Section: Discussionmentioning

confidence: 72%

“…Also, delay in use of prosthesis and multiple excision of pyogenic granuloma have been described as a cause of contracted socket. 10,11…”

Section: Discussionmentioning

confidence: 99%

Clinical use of cryopreserved ultra-thick human amniotic membrane for anophthalmic socket contracture

AlSemari,

AlZahrani,

Ahad

et al. 2023

European Journal of Ophthalmology

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“…Most patients have undergone one or several previous surgeries elsewhere, which complicated the current reconstruction and required the use of different surgical techniques. Anophthalmic orbit is a result of eyeball loss, after enucleation or evisceration (4). When this occurs in childhood or adolescence, as in the case described by us, the use of an orbital implant is indispensable to provide an adequate stimulus for the growth of bone structures of the orbit and to achieve facial symmetry.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of post-traumatic changes of eyelids, orbit and periorbital region

Koleva¹,

Sredkova²

2018

Bulgarian Review of Ophthalmology

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Цел: Да представим нашия опит в хирургичното лечение на пациенти с посттравматични промени в нормалната структура и функция на клепачите, орбитата и периорбиталната зона. Да опишем разнообразни реконструктивни техники и подходи, използвани при пациентите с този тип увреди. Методи: Представяме 17 пациенти на средна възраст 36 години (от 9 до 64 години); 5 жени и 12 мъже, претърпели хирургично лечение по повод посттравматични промени в областта на клепачите, орбитата и периорбиталната зона, за периода от март 2015 до април 2018. При петнадесет от представените пациенти наблюдаваните промени са посттравматични (давност на травмата от 15 години до 4 дни), като пациентите са били подложени на първична обработка и лечение в други звена, а проведените предходни оперативни интервенции често са били повече от една. Само при двама от представените 17 пациенти, осъществената от нас хирургична обработка е била първична. В един от описаните случаи, травмата на клепачите, орбитата и периорбиталната зона е била съчетана с увреждане на булба. В останалите-увредите ангажират само меките тъкани. В зависимост от наблюдаваните увреждания и зоните, които те ангажират, пациентите са разделени на четири основни групи: травматични промени в орбитата-2 пациенти; посттравматични цикатрициални промени на клепачите-12 пациенти (5 с цикатрициален ектропион и 7 с цикатрициален ентропион и трихиаза); посттравматична птоза-1 пациент, и разкъсно-контузни рани на клепача с ангажиране на слъзните каналикули-2 пациенти. Всички пациенти бяха подложени на хирургично лечение с използване на разнообразни реконструктивни техники. В три от случаите се наложи провеждане на операция на втори етап. Резултати: При всички пациенти постигнахме задоволителни естетични резултати. Постоперативно се възстанови нормалното положение на клепачите и тъканите от периорбиталната зона, което осигури протекция на очната повърхност и намаляване на оплакванията на пациентите. Заключение: Корекцията на посттравматичните промени често е предизвикателство за окулопластичните хирурзи. То изисква използването на разнообразни реконструктивни техники и методи, демонстрирани в нашето проучване. Постигането на добър резултат обаче е от важно значение за функционалната и социална рехабилитация на пациенти с подобни проблеми.

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“…Anophthalmia is the absence of the eyeball and its surrounding tissue from the orbital cavity. 1, 2 The majority of cases are caused by destructive eye surgery, such as evisceration. 2 Inadequate wound healing (following evisceration) might result in conjunctival and subconjunctival scarring that leads to socket contractures.…”

Section: Introductionmentioning

confidence: 99%

“…1, 2 The majority of cases are caused by destructive eye surgery, such as evisceration. 2 Inadequate wound healing (following evisceration) might result in conjunctival and subconjunctival scarring that leads to socket contractures. 3 Contracted socket is still a major problem for anophthalmic patients because the prosthetic eye cannot be properly attached, resulting in cosmetic eyelid issues such as entropion, ectropion, infection, and ptosis.…”

Section: Introductionmentioning

confidence: 99%

Fibrin glue as a novel therapy for contracted socket in comparison to mitomycin-c and triamcinolone acetonide at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

et al. 2022

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Background: Contracted socket is still a major problem for patients with anophthalmia. The main factor for this condition is inflammation and fibrosis, which result in conjunctival shortening. Myofibroblasts that express α-SMA are the primary mediators of anophthalmic socket contraction. Methods: One healthy eye of a New Zealand white rabbit were randomly selected for evisceration and divided into four treatment groups, each with five rabbits. Each rabbit in the group received a single subconjunctival injection of a different agent. Group, I was the control group that received no injection, Group II received MMC 0.4 mg/ml, Group III received TCA 40 mg/ml, and Group 4 received fibrin glue. After 14 days, the animals were euthanized, and conjunctival samples were submitted for histopathological analysis. A monoclonal α-SMA antibody was applied, and pathologists provided the IRS score for each sample. The differences in α-SMA expression were statistically analyzed with a significant level of p <0.05 Result: All groups displayed a statistically significant decrease in α-SMA expression compared to the control group (p<0.05) as sorting as MMC group with p=0.007, TCA group with p=0.007, and fibrin glue with p= 0.009. MMC was the most effective at reducing α-SMA (p=0.004). Surprisingly, there were no statistically significant differences between MMC, TCA, and fibrin glue when they were evaluated independently. Conclusion: A single subconjunctival injection of fibrin glue may be used as a novel treatment to prevent socket contracture in actively healing sockets.

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Anophthalmic socket- A cosmetic dilemma

Cited by 3 publications

References 7 publications

Clinical use of cryopreserved ultra-thick human amniotic membrane for anophthalmic socket contracture

Clinical use of cryopreserved ultra-thick human amniotic membrane for anophthalmic socket contracture

Surgical treatment of post-traumatic changes of eyelids, orbit and periorbital region

Fibrin glue as a novel therapy for contracted socket in comparison to mitomycin-c and triamcinolone acetonide at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

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