A review of 229 cases of fistula-in-ano in our institution has shown that nonspecific inflammatory tissue lines the majority of tracts. Epithelial lining was present in 50 cases and was encountered proportionately more frequently in subjects under 10 years of age, thus supporting a congenital origin as well as infection of anal glands, earlier proposed by other workers. Intestinal contents may have a role in the foreign body response seen in many cases. Locally endemic infectious conditions do not appear to play a significant role in the cause of the disease.JT Anim, SA Sowayan, CS Grant, H Al-Breiki, Fistula-In-Ano: A Pathological Study. 1991; 11(4): 377-380 Fistula-in-ano (FIA) is a disease that has been recognized since early times, but in spite of detailed early descriptions, our understanding of its pathogenesis is still unclear. The current consensus of an underlying infection of anal glands was first proposed by Herman and Desfosses in 1880 [1], and subsequently reinforced by other workers [2][3][4]. Since then, various clinicopathological aspects of the disease have been studied [5][6][7][8].A review of local Arab medical literature has yielded only a few reports on FIA, most clinical, with emphasis on management [9][10][11]. This paper is a review of all cases seen in the pathology department of our hospital.
Material and MethodsAll surgical specimens of FIA submitted to the pathology department of King Fahd Hospital of the University, Al-Khobar (KFHU), over the five-year period January 1984 to December 1988, were included in the study. The age and sex of the patients were obtained from the request forms. Hematoxylin and eosin slides were reviewed by two pathologists. Available special stains reviewed included: Ziehl-Neelsen stain, periodic acid-Schiff reaction, and Gram and Giemsa stains. Histological parameters examined included the presence and type of epithelium lining the fistulous tract, the type of the inflammatory response, granuloma formation, and presence of a foreign body. Organisms specifically looked for were: acid-fast bacilli, fungi, Schistosoma ova, and Leishmania organisms. No attempt was made to quantitate the histological features, although their interrelationships and possible relationship to pathogenesis were observed.
ResultsA total of 248 FIA specimens were seen in our laboratory during the five-year period. Nineteen specimens were adjudged unrepresentative and excluded from further study. Table 1 summarizes the age distribution of the remaining 229 FIA cases and shows a peak incidence in the fourth decade. There were 209 (91.3%) males versus 20 (8.7%) females, yielding a sex ratio of 10.5 males to 1 female.Partial or complete epithelial lining of the tract was observed in 50 cases (21.8%). Columnar epithelium similar to that lining the anal glands was the most common (Table 2), indicating the involvement of anal glands in the formation of FIA. Squamous epithelial lining, in combination with columnar, was found in the depths of the FIA in 10 of 50 cases (20%). Five of the 50 pa...