Anorectal dysfunctions in Parkinson's disease

Kim, Joong‐Seok; Sung, Hye Young; Lee, Kwang Soo; Kim, Yeong-In; Kim, Hee-Tae

doi:10.1016/j.jns.2011.05.048

Cited by 21 publications

(10 citation statements)

References 36 publications

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“…Constipation and defecatory dysfunction in patients with PD may be associated with abnormalities occurring during colonic inertia to the anal outlet 14. Defecatory dysfunction is a consequence of uncoordinated action of the muscles involved with defecation.…”

Section: Discussionmentioning

confidence: 99%

“…This functional outlet obstruction may cause both excessive straining and a sense of incomplete emptying, or sometimes, may induce painful defecation. 15–17 Another mechanism appears to involve the colonic musculature, which induces a slow passage of feces through the colon 14. Several studies have demonstrated considerably prolonged mean colonic transit time in PD patients 18…”

Section: Discussionmentioning

confidence: 99%

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The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease

Sung

Park

Kim

2014

JMD

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ObjectiveAlthough gastrointestinal dysfunctions occur in the majority of patients with Parkinson’s disease (PD), they are often unrecognized because many patients remain relatively asymptomatic in the early stage. We investigated the frequency of gastrointestinal symptoms in patients with PD using newly developed gastrointestinal symptom questionnaires.MethodsEarly PD patients with a symptom duration not exceeding 3 years were included in this study. All PD patients were evaluated using a questionnaire, which consisted of three relevant domains: oropharyngoesophageal (10 items); gastric (3 items); and intestinal-anorectal (7 items). The frequency of symptoms was calculated as a proportion with an item score ≥ 2.ResultsOf the 54 patients enrolled, 48 patients (88.9%) responded that bowel symptoms developed before the onset of Parkinsonian motor symptoms, and four patients reported that the onset of two types of symptoms (i.e., bowel and neurological) occurred approximately simultaneously, with only months between them. The frequencies of gastrointestinal symptoms are as follows: speech disturbance (40.7%), drooling (24.1%), sense of getting stuck (31.5%), choking (27.8%), globus pharyngis (16.7%), repetitive deglutition (29.6%), pain during swallowing (5.6%), food regurgitation (3.7%), acid reflux (7.4%), nausea/vomiting (11.1%), early satiety (16.7%), postprandial fullness (14.8%), epigastric soreness (9.3%), abdominal pain (3.7%), constipation (46.3%), excessive strain during defecation (33.3%), fecal incontinence (7.4%), tenesmus (20.4%), loose stool or diarrhea (3.7%), and difficulty in relaxing anal sphincter (11.1%). Two patients were scored at zero.ConclusionsOur findings confirm that gastrointestinal dysfunction occurs in early PD in relatively high frequency.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease

Sung

Park

Kim

2014

JMD

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“…(d).Constipation the most prominent GI dysfunction of PD seems to be an early manifestation of the disease process itself [9]. (e).Defecatorydysfunction characterized by excessive straining and incomplete evacuation are another common distressing problems in PD [57]. The study by Scheperjans and colleagues showed a reduced abundance of the Prevotellaceae bacteria family in PD patients compared with healthy controls and greater abundance of Enterobacteriaceae among those patients with the postural instability and gait difficulty phenotype compared to those with tremor-dominant PD [58],Prevotellaceae bacteria are commensals are involved in musin synthesis in the gut mucosal layer and production of neuroactive short-chain fatty acids (SCFA) through fiber fermentation [59].…”

Section: Gut-microbiota Link In Pdmentioning

confidence: 99%

Gut-Microbiota Link in Parkinson’s Disease: Current Perspectives

Mustafa¹,

Menon²,

Mansur³

et al. 2017

IOSR JDMS

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Abstract:Parkinson's disease(PD) is a metacentric neurodegenerative disorder results with accumulation and aggregation of alpha-synculein(α-Syn) (or alpha-synculeinopathy) Brain -gut axis(GBA) refers to central nervous system(CNS) control of the enteric nervous system(ENS) through vagus nerve intervention. PD is characterized by alphasynculeinopathy affecting all levels of the brain-gut axis.Both clinical and neuropathological evidences indicate the neurodegenerative changes in

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“…In addition, altered voluntary anal contraction (squeezing) and paradoxical anal contraction during straining (anismus) have been established in PD patients 5-7. However, most previous analyses were performed in advanced PD patients and the patients enrolled in those studies were not free from drug effects.…”

Section: Introductionmentioning

confidence: 99%

Anorectal Manometric Dysfunctions in Newly Diagnosed, Early-Stage Parkinson's Disease

et al. 2012

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Background and PurposeAnorectal dysmotility is common in advanced Parkinson's disease (PD), but there have been few evaluations in newly diagnosed PD patients.MethodsWe conducted anorectal manometric evaluations in 19 newly diagnosed, drug-naïve, early-stage PD patients. All of the PD patients were questioned regarding the presence of anorectal symptoms.ResultsAnorectal manometry was abnormal in 12 of the 19 patients. These abnormalities were more common in patients with more severe anorectal symptoms, as measured using a self-reported scale. However, more than 40% of patients with no or minimal symptoms also exhibited manometric abnormalities.ConclusionsThese results suggest that anorectal dysmotility manifests in many early-stage PD patients, which this represent evidence for the involvement of neuronal structures in such nonmotor manifestations in PD.

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Anorectal dysfunctions in Parkinson's disease

Cited by 21 publications

References 36 publications

The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease

The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease

Gut-Microbiota Link in Parkinson’s Disease: Current Perspectives

Anorectal Manometric Dysfunctions in Newly Diagnosed, Early-Stage Parkinson's Disease

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