Anorexia nervosa: A review of possible genetic factors

Scott, Derek Anthony

doi:10.1002/1098-108x(198601)5:1<1::aid-eat2260050102>3.0.co;2-e

Cited by 19 publications

(9 citation statements)

References 72 publications

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“…We consider it likely, that AN is a syndrome of multifactorial origin, and we are in accordance with Scott (28), who offers a diathesis-stress paradigm on the etiology of AN.…”

Section: Resultssupporting

confidence: 80%

Short stature as a possible etiological factor in anorexia nervosa

Brinch¹,

Manthorpe²

1987

Acta Psychiatr Scand

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The 21st case of concurrence of anorexia nervosa (AN) and gonadal dysgenesis (GD) or Turners syndrome is presented together with two more cases of AN in girls of short stature, but with normal chromosomes. The concurrence of AN and GD in the Danish population over a 10 year period is found not to be beyond the expected frequency. The possibility of low stature as such as an etiologic factor in AN is presented on the background of three cases. The same hypothesis has been suggested previously, but we cannot support the view of short stature as a common condition in AN patients premorbidly.

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“…We consider it likely, that AN is a syndrome of multifactorial origin, and we are in accordance with Scott (28), who offers a diathesis-stress paradigm on the etiology of AN.…”

Section: Resultssupporting

confidence: 80%

Short stature as a possible etiological factor in anorexia nervosa

Brinch¹,

Manthorpe²

1987

Acta Psychiatr Scand

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“…Studies along these lines might contribute to our knowledge of the interrelationships of affective and eating disorders. They might also be helpful in disentangling the confounded influences of sociocultural, geophysical and genetic factors (Aschoff, 1981;Rosenthal et al, 1983;Scott, 1986;Crow, 1987).…”

Section: Analyses In This Study Indicate a Season Of Onset Of An Withmentioning

confidence: 99%

Seasonal variation in anorexia nervosa? Some preliminary findings from a neglected area of research

Nielsen

1992

Int. J. Eat. Disord.

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A review of the literature on normal development and on psychiatric disorders related to seasonal variation, suggests that this phenomenon is probable to occur in anorexia nervosa. A search of the available literature is entirely negative with respect to seasonal variation in anorexia nervosa. Preliminary analysis suggests the existence of a season of onset, a season of birth, and also oi a season of admission in Danish female anorexia nervosa patients. A formally correct analysis for seasonal variation supports the existence of a season of onset in a selected sample, maximum is in May, amplitude 50%. A season of birth is found in an unselected nationwide sample of patients aged 15 years or older at first psychiatric admission for anorexia nervosa. Maximum late in April, amplitude 40% in the period 1963–1968. Season of admission could not be modelled as a sine wave, but the data suggested a pulse structure (a minimum in one month, followed by a maximum in the next month). Two annual pulses: December/January and July/August. Peak of onset is at a time of the year with maximum increase in height, and peak of other psychiatric conditions. Pattern of birth is similar to that reported for schizophrenia and mania. Replications of this preliminary study should be done in larger countries, at different latitudes and continents. Geophysical, demographic, and climatological variables should be controlled.

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“…what may be transmitted (genetically) is a basic genetic vulnerability to prenatal and neonatal difficulties." Scott (1986) in a review of evidence for a genetic predisposition to anorexia nervosa suggests that "the diathesis (genetic predisposition)-stress (environmental factors) paradigm seems as appropriate in accounting for AN as in accounting for schizophrenia." His description of the diathesis-stress paradigm is flawed by the omission of PBCs as significant risk factors in this model.…”

Section: To Anorexia Nervosamentioning

confidence: 99%

Chronicity in anorexia nervosa: Pregnancy and birth complications as risk factors

Bakan

Birmingham

Goldner

1991

Int. J. Eat. Disord.

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The chronic form of anorexia nervosa (AN) affects about one‐quarter of patients and has serious somatic and psychological consequences. This paper presents evidence in support of the hypothesis that pregnancy and birth complications (PBCs) associated with neuropathology may be risk factors for chronic anorexia nervosa. There is increasing evidence that PBCs are risk factors for other psychiatric and somatic disorders. Recent findings of possible premorbid neuropathology in patients with anorexia nervosa suggest that PBCs may be risk factors for chronicity in anorexia nervosa. Topics discussed include the origins of constitutional vulnerability to anorexia nervosa, correlates of PBCs and of chronic anorexia nervosa, the relationship of PBCs to neurological and neurochemical abnormalities, chronicity of anorexia nervosa in relation to PBCs and to neurological and neurochemical abnormalities, and the research implications of the hypothesis that PBCs and associated neuropathology are risk factors for chronicity in anorexia nervosa.

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Anorexia nervosa: A review of possible genetic factors

Cited by 19 publications

References 72 publications

Short stature as a possible etiological factor in anorexia nervosa

Short stature as a possible etiological factor in anorexia nervosa

Seasonal variation in anorexia nervosa? Some preliminary findings from a neglected area of research

Chronicity in anorexia nervosa: Pregnancy and birth complications as risk factors

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