Anorexia nervosa and insulin sensitivity: a systematic review and meta-analysis

Ilyas, Athif; Hübel, Christopher; Ismail, Khalida; Treasure, Janet; Breen, Gerome; Kan, Carol

doi:10.1016/s0924-977x(17)31180-x

Cited by 2 publications

(1 citation statement)

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“…Ghrelin peptide with orexigenic functions is elevated in AN and does not respond correctly after food intake [ 12 ]. Sensitivity to insulin (anorexigenic pancreatic hormone) is also increased in AN [ 13 ]. Stress, hyperactivity, and appetite are also modulated by the cortisol awakening response of hypothalamic–pituitary–adrenal (HPA) axis, being imbalanced in anxiety and AN [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Microbiota Imbalance in Anxiety and Eating Disorders: Probiotics as Novel Therapeutic Approaches

Navarro-Tapia

Almeida-Toledano

Sebastiani

et al. 2021

IJMS

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Anxiety and eating disorders produce a physiological imbalance that triggers alterations in the abundance and composition of gut microbiota. Moreover, the gut–brain axis can be altered by several factors such as diet, lifestyle, infections, and antibiotic treatment. Diet alterations generate gut dysbiosis, which affects immune system responses, inflammation mechanisms, the intestinal permeability, as well as the production of short chain fatty acids and neurotransmitters by gut microbiota, which are essential to the correct function of neurological processes. Recent studies indicated that patients with generalized anxiety or eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorders) show a specific profile of gut microbiota, and this imbalance can be partially restored after a single or multi-strain probiotic supplementation. Following the PRISMA methodology, the current review addresses the main microbial signatures observed in patients with generalized anxiety and/or eating disorders as well as the importance of probiotics as a preventive or a therapeutic tool in these pathologies.

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Section: Introductionmentioning

confidence: 99%