Anorexia nervosa and senna misuse: nephrocalcinosis, digital clubbing and hypertrophic osteoarthropathy

Lim, Andy; Hooke, David H.; Kerr, Peter G.

doi:10.5694/j.1326-5377.2008.tb01540.x

Cited by 15 publications

(7 citation statements)

References 4 publications

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“…To the Editor : I read with interest the letter by Lim and colleagues on anorexia nervosa and senna misuse 1 . I have seen abnormal whole body bone scans in patients with severe eating disorders of exactly the same pattern (except for the avid bilateral apical lung and gastric uptake) as the case described.…”

mentioning

confidence: 81%

Anorexia nervosa and senna misuse: nephrocalcinosis, digital clubbing and hypertrophic osteoarthropathy

McLaughlin

2008

Medical Journal of Australia

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mentioning

confidence: 81%

Anorexia nervosa and senna misuse: nephrocalcinosis, digital clubbing and hypertrophic osteoarthropathy

McLaughlin

2008

Medical Journal of Australia

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“…Furthermore, Hasegawa et al reported a patient with AN associated with tubulo-interstitial nephritis and hypokalemia who had biopsy-proven widespread calcification of the renal tubules (14). Although the exact pathophysiology is unclear, several other reports have also described cases of nephrocalcinosis among patients with AN (15)(16)(17). While our patient did not undergo a kidney biopsy, her hypokalemia had already been noted nine years earlier, and CT revealed bilateral medullary nephrocalcinosis.…”

Section: Discussionmentioning

confidence: 61%

Vitamin D Deficiency-induced Osteomalacia in a Patient with Anorexia Nervosa

et al. 2021

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A 48-year-old woman with a 9-year-history of anorexia nervosa (AN) was admitted complaining of generalized bone pain. Blood tests showed hypocalcemia and hyperphosphatasemia, and a radiological survey revealed multiple rib fractures, suggesting complication with osteomalacia. Two years earlier, she had undergone subtotal colectomy for colon cancer. Her serum 25-hydroxy vitamin D concentration was below the detectable level. In addition to a poor nutritional intake and insufficient sun exposure, malabsorption of fatsoluble substances in the intestine and phosphate loss from the kidneys might have contributed to the development of her osteomalacia.

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“…Similarly, many of the previously reported cases had associated hypokalaemia, chronic renal failure or fluid retention. Additionally, one report also linked a patient’s hypercalcaemia to the calcium in senna tablets (12.5 mg calcium per senna tablet) [5].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, one report also linked a patient’s hypercalcaemia to the calcium in senna tablets (12.5 mg calcium per senna tablet) [5].…”

Section: Discussionmentioning

confidence: 99%

Nail clubbing in laxative abuse: case report and review of the literature

et al. 2019

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Background The link between clubbing and laxative abuse has been reported several times in the literature, in all cases in young females. The nature of this relationship is not understood. Case A young female, with no history of hepatic, pulmonary or malignant disease was found to have nail clubbing in the context of laxative abuse. A literature review revealed several similar cases. Conclusion Laxative abuse is an important consideration in the assessment of clubbing in populations at risk of eating disorders, to prevent over-investigation and facilitate management of the eating disorder itself. This case highlights a new clinical presentation of an eating disorder. Case A 36-year-old woman was being reviewed by a renal specialist for renal impairment and electrolyte disturbances, in the context of a background of multiple renal calculi 4 years prior, hypokalaemia and hypercalcaemia. The attending nephrologist brought attention to her nails, which demonstrated clubbing. She stated that she had had clubbing for 10 years, and that it was of gradual onset and not associated with any pain. There was no history of hepatic, cardoipulmonary or malignant disease.

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Anorexia nervosa and senna misuse: nephrocalcinosis, digital clubbing and hypertrophic osteoarthropathy

Cited by 15 publications

References 4 publications

Anorexia nervosa and senna misuse: nephrocalcinosis, digital clubbing and hypertrophic osteoarthropathy

Anorexia nervosa and senna misuse: nephrocalcinosis, digital clubbing and hypertrophic osteoarthropathy

Vitamin D Deficiency-induced Osteomalacia in a Patient with Anorexia Nervosa

Nail clubbing in laxative abuse: case report and review of the literature

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